guanfacine (Intuniv, Tenex)

Brand Names: Intuniv, Tenex

Generic Name: guanfacine

What is guanfacine (Intuniv, Tenex)?

Guanfacine reduces nerve impulses in your heart and blood vessels. Guanfacine works by relaxing blood vessels, which lowers blood pressure and improves blood flow.

The Tenex brand of guanfacine is used to treat high blood pressure (hypertension). It is sometimes given with other blood pressure medications.

The Intuniv brand of guanfacine is used to treat attention deficit hyperactivity disorder (ADHD).

Guanfacine may also be used for purposes not listed in this medication guide.

What are the possible side effects of guanfacine (Intuniv, Tenex)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • anxiety, nervousness;
  • hallucinations (especially in children);
  • severe drowsiness;
  • slow heartbeats; or
  • a light-headed feeling, like you might pass out;

If you stop taking guanfacine, tell your doctor if you have headaches, confusion, rapid heartbeats, tremors, increased blood pressure, or if you feel nervous or agitated. If left untreated, these symptoms could lead to very high blood pressure, vision problems, or seizures.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about guanfacine (Intuniv, Tenex)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before taking guanfacine (Intuniv, Tenex)?

You should not use guanfacine if you are allergic to it.

Intuniv is not approved for use by anyone younger than 6 years old. Tenex is not approved for use by anyone younger than 12 years old.

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

How should I take guanfacine (Intuniv, Tenex)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take Intuniv with a full glass of water, milk, or other liquid.

Take Tenex at bedtime to ease drowsiness.

Swallow the Intuniv tablet whole and do not crush, chew, or break it.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Intuniv doses are based on weight in children, and any changes may affect your child's dose.

You should not stop using guanfacine suddenly. Stopping suddenly can raise your blood pressure and cause unpleasant symptoms.

Call your doctor if you are sick with vomiting and cannot take your medicine as usual.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.

Your doctor will need to check your progress on a regular basis. Your blood pressure and heart rate may also need to be checked.

If you have high blood pressure, keep using Tenex even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture, heat, and light.


The abbreviated term ADHD denotes the condition commonly known as: See Answer

What happens if I miss a dose (Intuniv, Tenex)?

Avoid taking guanfacine with high-fat foods, or your body could absorb the medicine too quickly.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss more than 2 doses in a row.

What happens if I overdose (Intuniv, Tenex)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, slow heart rate, and feeling like you might pass out.

What should I avoid while taking guanfacine (Intuniv, Tenex)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of guanfacine.

What other drugs will affect guanfacine (Intuniv, Tenex)?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Using guanfacine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your other medicines. Some may affect guanfacine, especially:

This list is not complete. Other drugs may affect guanfacine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Intuniv, Tenex)?

Your pharmacist can provide more information about guanfacine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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