hydrochlorothiazide and irbesartan (Avalide)

Brand Names: Avalide

Generic Name: hydrochlorothiazide and irbesartan

• What is hydrochlorothiazide and irbesartan (Avalide)?
• What are the possible side effects of hydrochlorothiazide and irbesartan (Avalide)?
• What is the most important information I should know about hydrochlorothiazide and irbesartan (Avalide)?
• What should I discuss with my healthcare provider before taking hydrochlorothiazide and irbesartan (Avalide)?
• How should I take hydrochlorothiazide and irbesartan (Avalide)?
• What happens if I miss a dose (Avalide)?
• What happens if I overdose (Avalide)?
• What should I avoid while taking hydrochlorothiazide and irbesartan (Avalide)?
• What other drugs will affect hydrochlorothiazide and irbesartan (Avalide)?
• Where can I get more information (Avalide)?

Hydrochlorothiazide and irbesartan is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and irbesartan contains a diuretic (water pill) and an angiotensin II receptor blocker (ARB).

Hydrochlorothiazide and irbesartan may also be used for purposes not listed in this medication guide.

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Avalide 12.5 mg-150 mg

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Avalide 12.5 mg-300 mg

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

• eye pain, vision problems;
• a light-headed feeling, like you might pass out;
• little or no urinating;
• jaundice (yellowing of the skin or eyes);
• easy bruising, unusual bleeding; or
• signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling.

Common side effects may include:

• dizziness;
• muscle or joint pain; or
• feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

You should not use this medicine if you are allergic to irbesartan or hydrochlorothiazide, or if:

• you are unable to urinate; or
• you are allergic to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking hydrochlorothiazide and irbesartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

• liver disease;
• congestive heart failure;
• glaucoma;
• low or high levels of potassium in your blood;
• asthma or allergies;
• high cholesterol or triglyceride levels;
• gout;
• lupus;
• diabetes; or
• an allergy to penicillin.

Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Hydrochlorothiazide and irbesartan can cause injury or death to the unborn baby if you take this medicine during your second or third trimester.

You should not breast-feed while using this medicine.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated.

If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and irbesartan.

It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

QUESTION

Salt and sodium are the same. See Answer

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and irbesartan.

Drinking alcohol can further lower your blood pressure and may cause side effects.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Tell your doctor about all your other medicines, especially:

• carbamazepine;
• insulin or oral diabetes medicine;
• lithium; or
• NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect hydrochlorothiazide and irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Your pharmacist can provide more information about hydrochlorothiazide and irbesartan.

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