Generic Name: hydromorphone (injection)
- What is hydromorphone injection?
- What are the possible side effects of hydromorphone injection?
- What is the most important information I should know about hydromorphone injection?
- What should I discuss with my healthcare provider before receiving hydromorphone injection?
- How is hydromorphone injection given?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while receiving hydromorphone injection?
- What other drugs will affect hydromorphone injection?
- Where can I get more information?
What is hydromorphone injection?
Hydromorphone injection is an opioid medicine used to treat moderate to severe pain.
Hydromorphone injection may also be used for purposes not listed in this medication guide.
What are the possible side effects of hydromorphone injection?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
- weak or shallow breathing;
- severe drowsiness;
- a light-headed feeling, like you might pass out; or
- low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common side effects may include:
- constipation, nausea, vomiting;
- dizziness, drowsiness;
- flushing (warmth, redness, or tingly feeling);
- sweating, itching;
- dry mouth;
- mood changes; or
- skin irritation or a hard lump where the injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about hydromorphone injection?
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Using opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
What should I discuss with my healthcare provider before receiving hydromorphone injection?
- severe asthma or breathing problems; or
- a bowel obstruction called paralytic ileus.
Do not use hydromorphone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You may not be able to use hydromorphone if you are NOT already being treated with a similar opioid (narcotic) pain medicine and are tolerant to it. Talk with your doctor if you are not sure you are opioid-tolerant.
Tell your doctor if you have ever had:
- any type of breathing problem or lung disease;
- a head injury, brain tumor, or seizures;
- alcoholism, drug addiction, mental illness;
- urination problems;
- liver or kidney disease;
- sulfite allergy;
- Addison's disease or other adrenal gland disorders; or
- problems with your gallbladder, pancreas, or thyroid.
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Hydromorphone can pass into breast milk and may cause drowsiness or breathing problems in a nursing baby. You should not breast-feed while you are using hydromorphone.
How is hydromorphone injection given?
Hydromorphone is injected under the skin or into a muscle, or as an infusion into a vein.
A healthcare provider will give you this injection. Hydromorphone is usually given by injection only if you are unable to take the medicine by mouth or use another form of hydromorphone.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Do not stop using hydromorphone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using hydromorphone.
What happens if I miss a dose?
Because you will receive hydromorphone in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A hydromorphone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
What should I avoid while receiving hydromorphone injection?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
What other drugs will affect hydromorphone injection?
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
- cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill");
- medicines for motion sickness, irritable bowel syndrome, or overactive bladder;
- other narcotic medications--opioid pain medicine or prescription cough medicine;
- a sedative like Valium--diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
- drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness;
- drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may affect hydromorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Where can I get more information?
Your doctor or pharmacist can provide more information about hydromorphone injection.
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