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imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)

Brand Names: Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage

Generic Name: imipenem and cilastatin

What is imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs.

Imipenem and cilastatin may also be used for purposes not listed in this medication guide.

What are the possible side effects of imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

You should not use this medicine if you are allergic to imipenem or cilastatin.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breast-feeding.

How should I use imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Imipenem and cilastatin is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Imipenem and cilastatin must be mixed with a liquid (diluent) before using it. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

This medicine must be given slowly, and the infusion can take 20 to 60 minutes to complete. If you feel nauseated while injecting this medicine, you may need to give it more slowly.

Imipenem and cilastatin is usually given as long as needed until your infection has cleared or you have been symptom-free for at least 48 hours.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Imipenem and cilastatin will not treat a viral infection such as the flu or a common cold.

Store unmixed medicine at room temperature, away from moisture and heat. After mixing imipenem and cilastatin, you must use it within 4 hours.

You may also store mixed medicine in the refrigerator for up to 24 hours. Do not freeze.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

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What happens if I miss a dose (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Call your doctor for instructions if you miss a dose.

What happens if I overdose (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What other drugs will affect imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect imipenem and cilastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)?

Your doctor or pharmacist can provide more information about imipenem and cilastatin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 2/6/2020

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