infliximab (Inflectra, Remicade, Renflexis)

Brand Names: Inflectra, Remicade, Renflexis

Generic Name: infliximab

What is infliximab (Inflectra, Remicade, Renflexis)?

Infliximab reduces the effects of a substance in the body that can cause inflammation.

Infliximab is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. Infliximab is also used to treat severe or disabling plaque psoriasis.

Infliximab is often used when other medicines have not been effective.

Infliximab may also be used for purposes not listed in this medication guide.

What are the possible side effects of infliximab (Inflectra, Remicade, Renflexis)?

Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, nauseated, light-headed, itchy or tingly, short of breath, or have a headache, fever, chills, muscle or joint pain, pain or tightness in your throat, chest pain, or trouble swallowing during the injection. Infusion reactions may also occur within 1 or 2 hours after injection.

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; fever, chills, severe dizziness; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with infliximab. Call your doctor right away if you have signs of infection such as: fever, extreme tiredness, flu symptoms, cough, or skin symptoms (pain, warmth, or redness).

Also call your doctor if you have:

  • skin changes, new growths on the skin;
  • pale skin, easy bruising or bleeding;
  • delayed allergic reaction (up to 12 days after receiving infliximab)--fever, sore throat, trouble swallowing, headache, joint or muscle pain, skin rash, or swelling in your face or hands;
  • liver problems--stomach pain (upper right side), tiredness, dark urine, jaundice (yellowing of the skin or eyes);
  • lupus-like syndrome--joint pain or swelling, chest discomfort, feeling short of breath, skin rash on your cheeks or arms (worsens in sunlight);
  • nerve problems--numbness or tingling, problems with vision, or weak feeling in your arms or legs, seizure;
  • new or worsening psoriasis--skin redness or scaly patches, raised bumps filled with pus;
  • signs of heart failure--shortness of breath with swelling of your ankles or feet, rapid weight gain;
  • signs of lymphoma--fever, night sweats, weight loss, stomach pain or swelling, chest pain, cough, trouble breathing, swollen glands (in your neck, armpits, or groin); or
  • signs of tuberculosis--fever, cough, night sweats, loss of appetite, weight loss, feeling constantly tired.

Common side effects may include:

  • stuffy nose, sinus pain;
  • sore throat, cough, chest pain;
  • headache, feeling light-headed;
  • rash, itching; or
  • stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about infliximab (Inflectra, Remicade, Renflexis)?

Using infliximab may increase your risk of developing certain types of cancer, including a rare fast-growing type of lymphoma that can be fatal. Ask your doctor about your specific risk.

Infliximab affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, tiredness, flu symptoms, cough, or skin pain.

What should I discuss with my healthcare provider before receiving infliximab (Inflectra, Remicade, Renflexis)?

You should not be treated with infliximab if you are allergic to it.

Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where certain infections are common (Ohio River Valley, Mississippi River Valley, and the Southwest).

Tell your doctor if you have ever had:

Make sure your child is current on all vaccines before he or she starts treatment with infliximab.

Infliximab may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn's disease or ulcerative colitis. However, anyone with an inflammatory autoimmune disorder may have a higher risk of lymphoma. Talk with your doctor about your own risk.

Infliximab may cause other types of cancer, such as skin cancer or cancer of the cervix. Ask your doctor about this risk.

If you use infliximab while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to infliximab in the womb could affect your baby's vaccination schedule during the first 6 months of life.

You should not breast-feed while you are receiving infliximab.

Infliximab is not for use in children younger than 6 years old.

How is infliximab given (Inflectra, Remicade, Renflexis)?

Before you start treatment with infliximab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Infliximab is given as an infusion into a vein. A healthcare provider will give you this injection.

You may be watched closely after receiving infliximab, to make sure the medicine has not caused any serious side effects.

Infliximab affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis, and you may need frequent TB tests.

If you need surgery, tell the surgeon ahead of time that you are using infliximab.

If you've ever had hepatitis B, using infliximab can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

What happens if I miss a dose (Inflectra, Remicade, Renflexis)?

Call your doctor for instructions if you miss an appointment for your infliximab injection.

What happens if I overdose (Inflectra, Remicade, Renflexis)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving infliximab (Inflectra, Remicade, Renflexis)?

Avoid activities that may increase your risk of bleeding injury.

Do not receive a "live" vaccine while using infliximab, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

What other drugs will affect infliximab (Inflectra, Remicade, Renflexis)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect infliximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Inflectra, Remicade, Renflexis)?

Your pharmacist can provide more information about infliximab.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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