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Medications and Drugs

Brand Names: Humulin R (Concentrated)

Generic Name: insulin regular, concentrated (U-500) (Pronunciation: IN soo lin)

What is concentrated insulin (Humulin R (Concentrated))?

Concentrated insulin is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Concentrated insulin (U-500) is a long-acting form of insulin that is different from other forms that are made from animal insulin.

Concentrated insulin is used to treat type 1 (insulin-dependent) diabetes in people with significant daily insulin needs (more than 200 units per day).

Concentrated insulin may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of concentrated insulin (Humulin R (Concentrated))?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor if you have any pain, redness, swelling, or skin changes where the insulin was injected.

Low blood sugar is the most common side effect of concentrated insulin. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, seizure (convulsions), or death. Watch for signs of low blood sugar.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about concentrated insulin (Humulin R (Concentrated))?

Concentrated insulin works differently from other types of insulin, and its effects may last for up to 24 hours after a single dose. Always check your medicine when it is refilled to make sure you have received the correct brand and type prescribed by your doctor.

While you are using concentrated insulin, do not use any other type of insulin or diabetes medications you take by mouth unless your doctor tells you to.

Take care to keep your blood sugar from getting too low, causing hypoglycemia. Symptoms of hypoglycemia may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, or trouble concentrating.

If your blood sugar gets too high (hyperglycemia), you may have symptoms such as increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting. Call your doctor right away if you have any of these symptoms.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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