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lanreotide (Somatuline Depot)

Brand Names: Somatuline Depot

Generic Name: lanreotide

What is lanreotide (Somatuline Depot)?

Lanreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion.

Lanreotide is used in adults to treat:

  • acromegaly that cannot be treated with surgery or radiation;
  • carcinoid syndrome; or
  • a certain type of pancreatic or digestive tract tumor that may spread to other parts of the body.

Lanreotide is sometimes given after other treatments have failed.

Lanreotide may also be used for purposes not listed in this medication guide.

What are the possible side effects of lanreotide (Somatuline Depot)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain, slow heartbeats;
  • shortness of breath;
  • a light-headed feeling, like you might pass out;
  • confusion, memory problems;
  • feeling very weak or tired;
  • a light-headed feeling, like you might pass out;
  • low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
  • underactive thyroid symptoms--tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures; or
  • signs of a gallbladder problem--sudden severe pain in your upper stomach spreading to your back or shoulder (may occur after meals or at night), nausea, fever, chills, yellowing of the skin or eyes.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about lanreotide (Somatuline Depot)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using lanreotide (Somatuline Depot)?

You should not use lanreotide if you are allergic to it.

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may affect fertility (your ability to have children) in women.

You should not breast-feed while using lanreotide and for at least 6 months after your last dose.

How is lanreotide given (Somatuline Depot)?

Lanreotide is injected under the skin.

A healthcare provider will give you this injection.

Lanreotide is usually given once every 4 weeks. Your doctor may occasionally change how often you receive injections.

Call your doctor if your symptoms do not improve, or if they get worse.

Your blood sugar may need to be checked often, and you may need other blood tests at your doctor's office.

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What happens if I miss a dose (Somatuline Depot)?

Call your doctor for instructions if you miss an appointment for your lanreotide injection.

What happens if I overdose (Somatuline Depot)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using lanreotide (Somatuline Depot)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect lanreotide (Somatuline Depot)?

When you start or stop taking lanreotide, your doctor may need to adjust the doses of any other medicines you take on a regular basis.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect lanreotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Somatuline Depot)?

Your doctor or pharmacist can provide more information about lanreotide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/24/2019

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