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Medications and Drugs

Brand Names: Methergine

Generic Name: methylergonovine (oral and injectable) (Pronunciation: meth il er GON o veen)

What is methylergonovine (Methergine)?

Methylergonovine is in a group of drugs called ergot alkaloids. It affects the smooth muscle of a woman's uterus, improving the muscle tone as well as the strength and timing of uterine contractions.

Methylergonovine is used just after a baby is born, to help deliver the placenta (also called the "afterbirth"). It is also used to help control bleeding and to improve muscle tone in the uterus after childbirth.

Methylergonovine may also be used for purposes than those listed in this medication guide.

Methergine 0.2 mg

round, pink, imprinted with SANDOZ, 78-54

What are the possible side effects of methylergonovine (Methergine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pain, swelling, warmth, or redness under your skin;
  • seizure (convulsions);
  • feeling like you might pass out;
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate, trouble breathing;
  • blood in your urine;
  • severe weakness, muscle cramps, confusion, slurred speech, fainting;
  • hallucinations;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • pain, swelling, warmth, or redness in one or both legs; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • nausea, mild stomach pain or vomiting, diarrhea;
  • increased sweating, mild skin rash;
  • leg cramps;
  • mild headache, dizziness;
  • ringing in your ears;
  • stuffy nose; or
  • unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methylergonovine (Methergine)?

You should not use methylergonovine during your pregnancy. This medication is to be used only after delivery of your baby.

Do not breast-feed within 12 hours after taking methylergonovine. Methylergonovine may pass into breast milk in small amounts and could affect a nursing baby. In some cases, you will need to use this medication for up to 1 week after your baby is born. You may need to use a breast pump to establish and maintain your milk flow until your methylergonovine treatment is finished. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Seek emergency medical attention if you think you have symptoms of possible methylergonovine overdose, such as nausea, vomiting, stomach pain, numbness or tingling, muscle twitching, feeling light-headed, fainting, shallow breathing, coldness, or seizure (convulsions).

There may be other drugs that can interact with methylergonovine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Grapefruit and grapefruit juice may interact with methylergonovine and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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