metyrosine (Demser)

Brand Names: Demser

Generic Name: metyrosine

What is metyrosine (Demser)?

Metyrosine is used to treat pheochromocytoma (tumor of the adrenal gland).

Metyrosine may also be used for purposes not listed in this medication guide.

What are the possible side effects of metyrosine (Demser)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • drooling, trouble speaking;
  • confusion, hallucinations;
  • tremors or muscle spasms;
  • painful or difficult urination;
  • urine that looks cloudy; or
  • severe or ongoing diarrhea.

Common side effects may include:

  • drowsiness; or
  • involuntary muscle movement.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about metyrosine (Demser)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before taking metyrosine (Demser)?

You should not use metyrosine if you are allergic to it.

Metyrosine is not approved for use by anyone younger than 12 years old.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breast-feeding.

How should I take metyrosine (Demser)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Drink 6 to 8 full glasses of water each day to help keep crystals from forming in your urine.

Metyrosine can affect the results of certain medical tests. Tell any doctor who treats you that you are using metyrosine.

Store at room temperature away from moisture and heat.

For 2 or 3 days after you stop taking metyrosine, you may have withdrawal symptoms such as trouble sleeping or increased alertness.


Salt and sodium are the same. See Answer

What happens if I miss a dose (Demser)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Demser)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include anxiety, depression, agitation, dry mouth, diarrhea, tremors or shaking, or tightness in your jaw.

What should I avoid while taking metyrosine (Demser)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can cause side effects.

What other drugs will affect metyrosine (Demser)?

Using metyrosine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all other medications you use, especially antipsychotic medicine.

Other drugs may affect metyrosine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Demser)?

Your pharmacist can provide more information about metyrosine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 3/17/2022

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