morphine (oral)

Generic Name: morphine

• What is morphine?
• What are the possible side effects of morphine?
• What is the most important information I should know about morphine?
• What should I discuss with my healthcare provider before using morphine?
• How should I use morphine?
• What happens if I miss a dose?
• What happens if I overdose?
• What should I avoid while using morphine?
• What other drugs will affect morphine?
• Where can I get more information?

Morphine is an opioid medication used to treat moderate to severe pain. Short-acting morphine is taken as needed for pain.

The extended-release form of morphine is for around-the-clock treatment of pain. This form of morphine is not for use on an as-needed basis for pain.

Morphine may also be used for purposes not listed in this medication guide.

000540235_PB

round, white, imprinted with 54 733

003782659_PB

round, purple, imprinted with M, MS 30

003782660_PB

round, orange, imprinted with M, MS 60

003782661_PB

round, gray, imprinted with M, MS 100

004068315_PB

round, blue, imprinted with 15, M inside square

004068320_PB

oblong, green, imprinted with 200, M inside square

004068330_PB

round, purple, imprinted with 30, M inside square

004068380_PB

round, orange, imprinted with 60, M inside square

004068390_PB

round, gray, imprinted with 100, M inside square

428580801_PB

round, blue, imprinted with ABG, 15

428580802_PB

round, purple, imprinted with ABG, 30

428580803_PB

round, orange, imprinted with ABG, 60

428580804_PB

round, gray, imprinted with ABG, 100

609510652_PB

round, blue, imprinted with 15, E652

609510653_PB

round, green, imprinted with 30, E653

609510655_PB

oblong, orange, imprinted with 60, E655

609510658_PB

oblong, blue, imprinted with 100, E658

609510659_PB

oval, green, imprinted with E659, 200

Avinza 120 mg

capsule, blue/white, imprinted with AVINZA, 120mg 508

Avinza 30 mg

capsule, white/yellow, imprinted with AVINZA, 30 mg 505

Avinza 45 mg

capsule, blue/white, imprinted with AVINZA, 45 MG 509

Avinza 60 mg

capsule, blue/white, imprinted with AVINZA, 60 mg 506

Avinza 90 mg

capsule, red/white, imprinted with AVINZA, 90 mg 507

Kadian 100 mg

capsule, green, imprinted with KADIAN, 100 mg

Kadian 20 mg 000236012

capsule, yellow, imprinted with KADIAN, 20 mg

Kadian 30 mg

capsule, blue, imprinted with KADIAN, 30 mg

Kadian 40 mg 000236014

capsule, blue/yellow, imprinted with KADIAN, 40 mg

Kadian 50 mg

capsule, blue, imprinted with KADIAN, 50 mg

Kadian 60 mg 000236016

capsule, pink, imprinted with KADIAN, 60 mg

Kadian 60 mg

capsule, pink, imprinted with KADIAN, 60 mg

Kadian 80 mg

capsule, orange, imprinted with KADIAN, 80 mg

morphine 100 mg ER 002283507

capsule, green, imprinted with KADIAN, 100 mg

morphine 100 mg ER 002284323

round, red, imprinted with 323, LOGO

morphine 120 mg ER 002283093

capsule, blue, imprinted with 3093

morphine 15 mg ER 002284270

round, white, imprinted with 270, LOGO

Morphine 15 mg-ROX

round, white, imprinted with 54 733

morphine 20 mg ER 002283502

capsule, yellow, imprinted with KADIAN, 20 mg

morphine 200 mg ER 002284347

oblong, red, imprinted with 347, LOGO

morphine 30 mg ER 002283090

capsule, blue, imprinted with 3090

morphine 30 mg ER 002284271

round, yellow, imprinted with 271, LOGO

Morphine 30 mg-ROX

round, white/blue specks, imprinted with 54 262

morphine 45 mg ER 002283116

capsule, purple, imprinted with 3116

morphine 50 mg ER 002283504

capsule, purple, imprinted with KADIAN, 50 mg

morphine 60 mg ER 002283091

capsule, green, imprinted with 3091

morphine 60 mg ER 002284311

round, pink, imprinted with LOGO, 311

morphine 75 mg ER 002283117

capsule, brown, imprinted with 3117

morphine 90 mg ER 002283092

capsule, green, imprinted with 3092

Morphine ER 100 mg 433860543

round, gray, imprinted with N 100

Morphine ER 100 mg 655970304

round, gray, imprinted with IDT M100

Morphine ER 15 mg 009046557

round, blue, imprinted with ABG, 15

Morphine ER 15 mg 433860540

round, blue, imprinted with n 15

Morphine ER 15 mg 633040450

round, blue, imprinted with RD 70

Morphine ER 15 mg 655970301

round, blue, imprinted with IDT M15

Morphine ER 15 mg 693440111

capsule, blue, imprinted with EGLT 15

Morphine ER 200 mg 000236019

capsule, brown, imprinted with KADIAN, 200 mg

Morphine ER 200 mg 433860544

capsule, green, imprinted with n 200

Morphine ER 30 mg 009046558

round, lavender, imprinted with ABG, 30

Morphine ER 30 mg 433860541

round, lavender, imprinted with n 30

Morphine ER 30 mg 633040451

round, purple, imprinted with RD 71

Morphine ER 30 mg 655970302

round, purple, imprinted with IDT M30

Morphine ER 30 mg 693440211

capsule, purple, imprinted with EGLT30

Morphine ER 60 mg 009046559

round, orange, imprinted with ABG, 60

Morphine ER 60 mg 433860542

round, orange, imprinted with n 60

Morphine ER 60 mg 655970303

round, orange, imprinted with IDT M60

Morphine ER 60 mg 693440311

capsule, orange, imprinted with EGLT 60

Morphine IR 15 mg-ETH

round, brown, imprinted with 15, ETH

Morphine IR 30 mg-ETH

oblong, brown, imprinted with 30, ETHEX

Morphine Sulfate ER 100 mg-UPS

capsule, green, imprinted with UPSHER-SMITH 0233, 100 mg

Morphine Sulfate ER 20 mg-UPS

capsule, yellow, imprinted with UPSHIRE-SMITH 0226, 20 mg

Morphine Sulfate ER 30 mg-UPS

capsule, purple, imprinted with UPSHER-SMITH 0227, 30 mg

Morphine Sulfate ER 60 mg-UPS

capsule, pink, imprinted with UPSHER-SMITH 0229, 60 mg

MS Contin 100 mg

round, gray, imprinted with PF, 100

MS Contin 30 mg

round, pink, imprinted with PF, M 30

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

• slow heart rate, sighing, weak or shallow breathing, breathing that stops during sleep;
• chest pain, fast or pounding heartbeats;
• extreme drowsiness, feeling like you might pass out; or
• low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

• drowsiness, dizziness, tiredness;
• constipation, stomach pain, nausea, vomiting;
• sweating; or
• feelings of extreme happiness or sadness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

You should not take this medicine if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have:

• severe asthma or breathing problems; or
• a blockage in your stomach or intestines.

Do not use morphine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

• breathing problems, sleep apnea;
• a head injury, brain tumor, or seizures;
• a drug or alcohol addiction, or mental illness;
• urination problems;
• liver or kidney disease; or
• problems with your gallbladder, pancreas, or thyroid.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Do not breast-feed while taking morphine. This medicine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.

Follow the directions on your prescription label and read all medication guides. Never use morphine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Stop taking all other around-the-clock narcotic pain medications when you start taking morphine.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Never crush or break a morphine pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of morphine and similar prescription drugs.

Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer

Morphine is sometimes taken only once per day, and sometimes 2 or 3 times per day. Since morphine is used for pain, you are not likely to miss a dose. If you do miss a dose, take the medicine as soon as you remember. Then take your next dose as follows:

• If you take morphine 3 times per day: Take your next dose 8 hours after taking the missed dose.
• If you take morphine 2 times per day: Take your next dose 12 hours after taking the missed dose.
• If you take morphine 1 time per day: Take your next dose 24 hours after taking the missed dose.

Do not take two doses at one time. Do not take more than your prescribed dose in a 24-hour period.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A morphine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, very slow breathing, or coma.

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

• other narcotic medications--opioid pain medicine or prescription cough medicine;
• a sedative like Valium--diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others;
• drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, tranquilizer, antidepressant, or antipsychotic medicine; or
• drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

This list is not complete. Other drugs may affect morphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Your doctor or pharmacist can provide more information about morphine.

Copyright 1996-2019 Cerner Multum, Inc.