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naloxone and pentazocine (oral) (Talwin NX)

Brand Names: Talwin NX

Generic Name: naloxone and pentazocine (oral)

What is naloxone and pentazocine (Talwin NX)?

Naloxone blocks certain effects of opioid medication, including feelings of well-being that can lead to opioid abuse. Pentazocine is an opioid pain medication, sometimes called a narcotic.

Naloxone and pentazocine is a combination medicine used to treat moderate to severe pain. Naloxone is included in this medication to prevent the misuse of the narcotic ingredient.

Naloxone and pentazocine may also be used for purposes not listed in this medication guide.

What are the possible side effects of naloxone and pentazocine (Talwin NX)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • slow heartbeats, weak or shallow breathing, breathing that stops during sleep;
  • severe constipation;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe weakness or drowsiness;
  • seizure (convulsions);
  • a light-headed feeling, like you might pass out;
  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about naloxone and pentazocine (Talwin NX)?

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

What should I discuss with my healthcare provider before taking naloxone and pentazocine (Talwin NX)?

You should not use this medicine if you are allergic to naloxone or pentazocine.

Tell your doctor if you have ever had:

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with naloxone and pentazocine and cause a serious condition called serotonin syndrome.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

If you breastfeed while taking this medicine, tell your doctor if your baby is very drowsy or has breathing problems.

Naloxone and pentazocine is not approved for use by anyone younger than 12 years old.

How should I take naloxone and pentazocine (Talwin NX)?

Follow the directions on your prescription label and read all medication guides. Never use naloxone and pentazocine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Naloxone and pentazocine is usually taken as 1 or 2 tablets every 3 to 4 hours. Follow your doctor's instructions. Do not take more than 12 tablets in a 24-hour period.

If you are using any other narcotic pain medicine, the pain-relieving effects of the narcotic may be reversed while you are also taking naloxone and pentazocine.

Never crush or break a naloxone and pentazocine pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.

You should not stop using this medicine suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

SLIDESHOW

Pain Management: Surprising Causes of Pain See Slideshow

What happens if I miss a dose (Talwin NX)?

Since naloxone and pentazocine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

Do not take more than 12 tablets in a 24-hour period.

What happens if I overdose (Talwin NX)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A pentazocine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include anxiety, nightmares, hallucinations, slow breathing, fast heart rate, severe dizziness, vomiting, numbness or tingling, fainting, or seizure (convulsions).

What should I avoid while taking naloxone and pentazocine (Talwin NX)?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Avoid smoking, which can make this medication less effective in relieving your pain.

What other drugs will affect naloxone and pentazocine (Talwin NX)?

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may affect naloxone and pentazocine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information (Talwin NX)?

Your pharmacist can provide more information about naloxone and pentazocine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 2/6/2020

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