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nefazodone (cont.)

What should I discuss with my healthcare provider before taking nefazodone ()?

You should not take this medication if you are allergic to nefazodone or trazodone (Desyrel), or if you have ever had liver problems caused by taking nefazodone.

Do not take nefazodone if you are using any of the following drugs:

  • carbamazepine (Tegretol);
  • cisapride (Propulsid);
  • pimozide (Orap); or
  • an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

Serious and sometimes fatal reactions can occur when these medicines are taken with nefazodone. You must wait at least 14 days after stopping an MAO inhibitor before you can take nefazodone. You must wait 7 days after stopping nefazodone before you can take an MAOI.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take nefazodone:

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether nefazodone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether nefazodone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take nefazodone ()?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from the medication.

You may take nefazodone with or without food.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking nefazodone. You may need to stop using the medicine for a short time.

It may take several weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed.

Store nefazodone at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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