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Medications and Drugs

Brand Names: Zofran

Generic Name: ondansetron (injection) (Pronunciation: on DAN se tron)

What is ondansetron (Zofran)?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron injection is used to prevent nausea and vomiting that may be caused by surgery or medicine to treat cancer (chemotherapy).

Ondansetron injection may also be used for purposes not listed in this medication guide.

What are the possible side effects of ondansetron (Zofran)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Other common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ondansetron (Zofran)?

You should not use ondansetron if you are allergic to it, or if you are also using apomorphine (Apokyn).

You should not use this medication if you have a history of Long QT syndrome. Ondansetron can cause serious heart rhythm problems.

Before receiving ondansetron injection, tell your doctor if you have liver disease, heart disease, a heart rhythm disorder, congestive heart failure, or low potassium or magnesium levels in your blood.

Tell your doctor about all other medicines you use. There are many other medicines that can increase your risk of heart rhythm problems if you use them together with ondansetron.

Call your doctor at once if you have fast, slow, or uneven heartbeats, or if you feel like you might pass out.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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