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oxymetazoline nasal (12 Hour Nasal, 12 Hour Nasal Decongestant, Afrin)

Brand Names: 12 Hour Nasal, 12 Hour Nasal Decongestant, Afrin, Afrin All Night NoDrip, Afrin Extra Moisturizing, Afrin Nasal Sinus, Afrin No Drip Severe Congestion, Afrin No Drip Sinus, Afrin NoDrip Extra Moisturizing, Afrin Pump Mist, Afrin Severe Congestion, Afrin Severe Congestion NoDrip, Allerest 12 Hour Nasal Spray, Dristan 12-Hour, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Mucinex Moisture Smart, Mucinex Sinus-Max Full Force, Mucinex Sinus-Max Moisture Smart, Nasal Mist, Neo-Synephrine 12 Hour, Neo-Synephrine 12 Hour Extra Moisturizing, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex 12 Hour, Sinex 12 Hour Moisturizing, Sinex 12 Hour Ultra Fine Mist, Sinex Long-Acting, Sudafed OM Sinus Cold, Sudafed OM Sinus Congestion, Twice-A-Day, Zicam Extreme Congestion Relief, Zicam Sinus Relief

Generic Name: oxymetazoline nasal

What is oxymetazoline nasal?

Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Oxymetazoline nasal (for the nose) is for temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.

Oxymetazoline nasal may also be used for purposes not listed in this medication guide.

What are the possible side effects of oxymetazoline nasal?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using oxymetazoline nasal and call your doctor at once if you have:

  • ongoing or worsening symptoms;
  • severe burning or stinging in your nose after using the nasal spray;
  • chest pain, fast or uneven heart rate; or
  • severe headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.

Common side effects may include:

  • mild burning or stinging of the nose;
  • sneezing; or
  • runny nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about oxymetazoline nasal?

Oxymetazoline nasal (for the nose) is used for temporary relief of nasal congestion caused by allergies or the common cold.

Stop using this medicine and call your doctor at once if you have ongoing or worsening symptoms, or if you have severe burning or stinging in your nose after using the nasal spray

What should I discuss with my healthcare provider before using oxymetazoline nasal?

You should not use oxymetazoline nasal if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

FDA pregnancy category C. It is not known whether oxymetazoline nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether oxymetazoline nasal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use oxymetazoline nasal?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Using the medication too long or too often may worsen your symptoms or cause nasal congestion to clear up and come back.

Call your doctor if your symptoms do not improve after 3 days of treatment.

Do not share this medication with another person, even if they have the same symptoms you have. Sharing a nasal spray bottle can spread infection.

To use the nose drops (nasal solution):

  • Blow your nose gently. Tilt your head back as far as possible, or lie down and hang your head over the side of a bed. Hold the dropper over your nose and place the correct number of drops into your nose.
  • Sit up and bend your head slightly forward, then move it gently left and right. Stay seated with your head bent forward for a few minutes.
  • Avoid sneezing or blowing your nose for at least a few minutes after using the nose drops.

To use the nasal spray:

  • Blow your nose gently. Keep your head upright and insert the tip of bottle into one nostril. Press your other nostril closed with your finger. Breathe in quickly and gently spray the medicine into your nose. Then use the spray in your other nostril.
  • Do not blow your nose for at least a few minutes after using the nasal spray.

Do not use the nasal spray more than 2 times in 24 hours.

Wipe the tip of the spray bottle with a clean tissue but do not wash with water or soap.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep this medicine out of the reach of children. Certain nasal medications can cause serious medical problems in a young child who accidentally sucks on or swallows medicine from the nasal spray bottle.

What should I avoid while using oxymetazoline nasal?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect oxymetazoline nasal?

Ask a doctor or pharmacist if it is safe for you to use oxymetazoline nasal if you are also using any of the following drugs:

This list is not complete and other drugs may interact with oxymetazoline nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about oxymetazoline nasal.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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