penciclovir topical (Denavir)

Brand Names: Denavir

Generic Name: penciclovir topical

What is penciclovir topical (Denavir)?

Penciclovir topical (for the skin) is an antiviral medication that is used to treat cold sores on the lips that are caused by the herpes simplex virus. This medicine is for adults and children who are at least 12 years old.

Penciclovir topical is not a cure for cold sores and you may continue to have them in the future.

Penciclovir topical may also be used for purposes not listed in this medication guide.

What are the possible side effects of penciclovir topical (Denavir)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe skin redness, itching, rash, or pain after applying this medicine.

Common side effects may include:

  • numbness or tingling where the medicine was applied;
  • headache; or
  • changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about penciclovir topical (Denavir)?

Do not apply penciclovir topical to the inside of the nose or in or near the eyes.

What should I discuss with my healthcare provider before using penciclovir topical (Denavir)?

You should not use penciclovir topical if you are allergic to it.

Since penciclovir topical is not absorbed into the body, using this medicine is not expected to be harmful if you are pregnant or breast-feeding.

Penciclovir topical is not approved for use by anyone younger than 12 years old.

How should I use penciclovir topical (Denavir)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Penciclovir topical is for use only on the lips and face. If this medicine gets in your nose or mouth, rinse with water.

Start using this medicine when you first notice cold sore symptoms (tingling, redness, itching, or a bump).

Wash your hands before and after applying the medicine.

Apply every 2 hours throughout the day for 4 days in a row.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature.


Ringworm is caused by a fungus. See Answer

What happens if I miss a dose (Denavir)?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose (Denavir)?

An overdose of penciclovir topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using penciclovir topical (Denavir)?

Do not apply penciclovir topical to the inside of your nose or near your eyes.

What other drugs will affect penciclovir topical (Denavir)?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information (Denavir)?

Your pharmacist can provide more information about penciclovir topical.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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