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Medications and Drugs

Brand Names: Orap

Generic Name: pimozide (Pronunciation: PIM oh zide)

What is pimozide (Orap)?

Pimozide is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Pimozide is used to suppress the motor and phonic tics associated with Tourette's disorder.

Pimozide may also be used for purposes not listed in this medication guide.

Orap 2 mg

elliptical, white, imprinted with LEMMON, ORAP 2

What are the possible side effects of pimozide (Orap)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • seizure (convulsions);
  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or
  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pimozide (Orap)?

There are many other drugs that can cause serious or life threatening medical problems if you take them together with pimozide, especially if you have a heart rhythm disorder. Tell your doctor about all other medicines you use.

Grapefruit and grapefruit juice may interact with pimozide and lead to potentially dangerous effects. Avoid eating or drinking grapefruit products while taking this medication.

Pimozide may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of pimozide.

Call your doctor right away if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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