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prochlorperazine (oral/injection) (Compazine, Procot)

Brand Names: Compazine, Procot

Generic Name: prochlorperazine (oral/injection)

What is prochlorperazine (Compazine, Procot)?

Prochlorperazine is a phenothiazine (FEEN-oh-THYE-a-zeen) antipsychotic medicine.

Prochlorperazine is used to treat psychotic disorders such as schizophrenia.

Prochlorperazine is also used to control severe nausea and vomiting.

Prochlorperazine may also be used for purposes not listed in this medication guide.

What are the possible side effects of prochlorperazine (Compazine, Procot)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of prochlorperazine can cause a serious movement disorder that may not be reversible. The longer you use prochlorperazine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • trouble speaking or swallowing, stiffness or muscle spasms in your neck;
  • tremors, or any new or unusual muscle movements you cannot control;
  • extreme drowsiness or light-headed feeling (like you might pass out);
  • little or no urination;
  • agitation, restlessness;
  • severe constipation, stomach pain, bloating;
  • jaundice (yellowing of the skin or eyes);
  • low blood cell counts--fever, chills, sore throat, cough, trouble breathing, mouth sores, skin sores, pale skin, easy bruising or bleeding;
  • lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats.

Some serious side effects may be more likely in children or in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about prochlorperazine (Compazine, Procot)?

You should not use prochlorperazine if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications.

Prochlorperazine is not approved for use by anyone younger than 2 years old or weighing less than 20 pounds. Do not give this medicine to a child before or after a surgery.

Prochlorperazine is not approved for use in older adults with dementia-related conditions.

Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

What should I discuss with my healthcare provider before using prochlorperazine (Compazine, Procot)?

You should not use this medicine if you are allergic to prochlorperazine or other phenothiazines (such as chlorpromazine, fluphenazine, perphenazine, promethazine, thioridazine, trifluoperazine).

Do not use prochlorperazine if you have recently used large amounts of alcohol or medicine that makes you sleepy.

Prochlorperazine is not approved for use by anyone younger than 2 years old or weighing less than 20 pounds. Talk with your doctor before giving prochlorperazine to a child or teenager with a fever, flu symptoms, vomiting, or diarrhea.

Do not give this medicine to a child before or after a surgery.

Prochlorperazine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Tell your doctor if you have ever had:

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using prochlorperazine.

Using antipsychotic medicine in the last 3 months of pregnancy may cause drowsiness, breathing problems, feeding problems, fussiness, tremors, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop using prochlorperazine without your doctor's advice.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use prochlorperazine (Compazine, Procot)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Prochlorperazine oral is taken by mouth.

Prochlorperazine doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Prochlorperazine injection is injected into a muscle or as an infusion into a vein. A healthcare provider will give you this injection.

After receiving a prochlorperazine injection, you may need to remain lying down for at least 30 minutes. You may feel light-headed when you first stand up.

If you use prochlorperazine long-term, you may need frequent medical tests.

Do not stop using prochlorperazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

QUESTION

Panic attacks are repeated attacks of fear that can last for several minutes. See Answer

What happens if I miss a dose (Compazine, Procot)?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose (Compazine, Procot)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause severe drowsiness, irregular heartbeats, agitation, seizure, or fainting.

What should I avoid while using prochlorperazine (Compazine, Procot)?

Drinking alcohol with this medicine can cause side effects.

Avoid driving or hazardous activity until you know how this medicine will affect you. This medicine may cause dizziness or blurred vision and may impair your reactions. Dizziness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Prochlorperazine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect prochlorperazine (Compazine, Procot)?

Using prochlorperazine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can affect prochlorperazine, especially:

This list is not complete and many other drugs may affect prochlorperazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Compazine, Procot)?

Your pharmacist can provide more information about oral prochlorperazine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 2/6/2020

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