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quetiapine (SEROquel, SEROquel XR)

Brand Names: SEROquel, SEROquel XR

Generic Name: quetiapine

What is quetiapine (SEROquel, SEROquel XR)?

Quetiapine is an antipsychotic medicine that is used to treat schizophrenia in adults and children who are at least 13 years old.

Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults.

Quetiapine may also be used for purposes not listed in this medication guide.

What are the possible side effects of quetiapine (SEROquel, SEROquel XR)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • mask-like appearance of the face, trouble swallowing, problems with speech;
  • a light-headed feeling, like you might pass out;
  • severe constipation;
  • painful or difficult urination;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about quetiapine (SEROquel, SEROquel XR)?

Some people have thoughts about suicide while taking quetiapine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Quetiapine is not approved for use in older adults with dementia-related conditions.

What should I discuss with my healthcare provider before taking quetiapine (SEROquel, SEROquel XR)?

You should not use quetiapine if you are allergic to it.

Quetiapine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Quetiapine is not approved for use by anyone younger than 10 years old.

Tell your doctor if you have ever had:

Some people have thoughts about suicide while taking quetiapine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking quetiapine without your doctor's advice.

You should not breast-feed while you are using quetiapine.

How should I take quetiapine (SEROquel, SEROquel XR)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. The longer you use quetiapine, the more likely you are to develop this disorder, especially if you are an older adult. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

You may take Seroquel with or without food.

You should take Seroquel XR without food or with a light meal.

Swallow the tablet whole and do not crush, chew, or break it.

Quetiapine may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis.

Drink plenty of liquids while you are taking quetiapine.

Blood pressure may need to be checked often in a child or teenager taking quetiapine.

You should not stop using quetiapine suddenly. Stopping suddenly may make your condition worse.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use quetiapine.

Store at room temperature away from moisture and heat.

SLIDESHOW

Bipolar Disorder: Symptoms, Testing for Bipolar Depression See Slideshow

What happens if I miss a dose (SEROquel, SEROquel XR)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (SEROquel, SEROquel XR)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of quetiapine can be fatal.

What should I avoid while taking quetiapine (SEROquel, SEROquel XR)?

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke.

What other drugs will affect quetiapine (SEROquel, SEROquel XR)?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Quetiapine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect quetiapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (SEROquel, SEROquel XR)?

Your pharmacist can provide more information about quetiapine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/24/2019

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