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Medications and Drugs

Brand Names: Lucentis

Generic Name: ranibizumab (ophthalmic) (Pronunciation: ra NIB i ZUE mab off THAL mik)

What is ranibizumab (Lucentis)?

Ranibizumab is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with a certain type of eye disease, new blood vessels grow under the retina where they leak blood and fluid. This is known as the "wet form" of macular degeneration.

Ranibizumab ophthalmic (for the eyes) is used to treat wet age-related macular degeneration. Ranibizumab is also used to treat swelling in the retina caused by diabetes or by a blockage in the blood vessels.

Ranibizumab may also be used for purposes not listed in this medication guide.

What are the possible side effects of ranibizumab (Lucentis)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • eye pain or redness, swelling around your eyes;
  • sudden vision problems;
  • discharge or bleeding from the eye;
  • eyes being more sensitive to light;
  • seeing flashes of light or "floaters" in your vision;
  • feeling like something is in your eye;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with speech or balance; or
  • pain or burning when you urinate.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ranibizumab (Lucentis)?

You should not receive ranibizumab if you are allergic to it, or if you have any type of infection in or around your eyes.

Before you receive this medication, tell your doctor if you have glaucoma, or a history of blood clots or stroke.

Call your doctor at once if you have sudden vision problems, eye pain or irritation, discharge or bleeding from the eye, swelling around your eye, seeing flashes of light or "floaters" in your vision, sudden numbness or weakness in your body, sudden severe headache, or problems with speech or balance.

Call your doctor for instructions if you miss an appointment to receive your ranibizumab injection. The timing of your monthly injections is very important for this medication to be effective.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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