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sacubitril and valsartan (Entresto)

Brand Names: Entresto

Generic Name: sacubitril and valsartan

What is sacubitril and valsartan (Entresto)?

Sacubitril and valsartan are blood pressure medicines. Valsartan is an angiotensin II receptor blocker (sometimes called an ARB).

Sacubitril and valsartan is a combination medicine that is used in certain people with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure.

Sacubitril and valsartan is usually given together with other blood pressure medications.

Sacubitril and valsartan may also be used for purposes not listed in this medication guide.

What are the possible side effects of sacubitril and valsartan (Entresto)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Also call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • extreme tiredness;
  • high potassium--slow heart rate, weak pulse, muscle weakness, tingly feeling; or
  • kidney problems--little or no urination, rapid weight gain, painful or difficult urination, swelling in your hands, feet, or ankles.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sacubitril and valsartan (Entresto)?

Do not use if you are pregnant, and tell your doctor right away if you become pregnant.

If you have diabetes, do not use sacubitril and valsartan together with any medication that contains aliskiren (a blood pressure medicine).

What should I discuss with my healthcare provider before taking sacubitril and valsartan (Entresto)?

You should not use this medicine if you are allergic to sacubitril or valsartan (Diovan), or if you have ever had a severe allergic reaction to a blood pressure medication such as:

You should not take sacubitril and valsartan within 36 hours before or after you have taken any ACE inhibitor medication.

If you have diabetes, do not use sacubitril and valsartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking sacubitril and valsartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Sacubitril and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while using this medicine.

How should I take sacubitril and valsartan (Entresto)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food.

Your blood pressure will need to be checked often. Your kidney function may also need to be checked.

Store at room temperature away from moisture and heat.

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow

What happens if I miss a dose (Entresto)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Entresto)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sacubitril and valsartan (Entresto)?

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

What other drugs will affect sacubitril and valsartan (Entresto)?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may affect sacubitril and valsartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Entresto)?

Your pharmacist can provide more information about sacubitril and valsartan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/24/2019

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