Brand Names: Rapaflo

Generic Name: silodosin

What is silodosin (Rapaflo)?
What are the possible side effects of silodosin (Rapaflo)?
What is the most important information I should know about silodosin (Rapaflo)?
What should I discuss with my healthcare provider before taking silodosin (Rapaflo)?
How should I take silodosin (Rapaflo)?
What happens if I miss a dose (Rapaflo)?
What happens if I overdose (Rapaflo)?
What should I avoid while taking silodosin (Rapaflo)?
What other drugs will affect silodosin (Rapaflo)?
Where can I get more information (Rapaflo)?

What is silodosin (Rapaflo)?

Silodosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker that is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Silodosin may also be used for purposes not listed in this medication guide.

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capsule, white, imprinted with WATSON 151, 4 mg

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capsule, white, imprinted with WATSON 152, 8 mg

What are the possible side effects of silodosin (Rapaflo)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe dizziness, or if you feel like you might pass out.

severe dizziness, or if you feel like you might pass out.

Common side effects may include:

dizziness;
headache;
diarrhea;
abnormal ejaculation; or
stuffy nose, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about silodosin (Rapaflo)?

You should not take silodosin if you have severe kidney or liver disease.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What should I discuss with my healthcare provider before taking silodosin (Rapaflo)?

You should not take silodosin if you are allergic to it, or if you have:

severe liver disease; or
severe kidney disease.

Some medicines can cause unwanted or dangerous effects when used with silodosin. Your doctor may change your treatment plan if you also use:

imatinib;
isoniazid;
nefazodone;
an antibiotic--clarithromycin, telithromycin;
antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole;
heart medication--nicardipine, quinidine;
antiviral medicine to treat hepatitis C or HIV/AIDS--atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir; or
medicines similar to silodosin--alfuzosin, doxazosin, prazosin, tamsulosin, or terazosin.

Tell your doctor if you have ever had:

low blood pressure;
kidney disease (or if you are on dialysis);
heart disease;
prostate cancer;
a condition for which you take a diuretic or "water pill"; or
if you are on a low-salt diet.

Silodosin can affect your pupils. If you have cataract surgery, tell your surgeon ahead of time that you use this medicine.

Silodosin is not for use in women, and the effects of this medicine during pregnancy or in breastfeeding women are unknown.

Silodosin is not approved for use by anyone younger than 18 years old.

How should I take silodosin (Rapaflo)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Silodosin is usually taken once daily with a meal. Follow your doctor's dosing instructions very carefully.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing, then drink a full glass of water.

Silodosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Your blood pressure and prostate will need to be checked often.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.

Store at room temperature away from moisture, heat, and light.

QUESTION

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What happens if I miss a dose (Rapaflo)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Rapaflo)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking silodosin (Rapaflo)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

What other drugs will affect silodosin (Rapaflo)?

Many drugs can affect silodosin, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information (Rapaflo)?

Your pharmacist can provide more information about silodosin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.