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sodium biphosphate and sodium phosphate (oral) (Fleet EZ-Prep, Fleet Phospho Soda, OsmoPrep)

Brand Names: Fleet EZ-Prep, Fleet Phospho Soda, OsmoPrep, Phosphate Laxative, Visicol

Generic Name: sodium biphosphate and sodium phosphate (oral)

What is oral sodium biphosphate and sodium phosphate?

Sodium biphosphate and sodium phosphate is a combination medicine used in adults to treat constipation and to clean the bowel before a colonoscopy.

Sodium biphosphate and sodium phosphate may also be used for purposes not listed in this medication guide.

What are the possible side effects of oral sodium biphosphate and sodium phosphate?

Get emergency medical help if you have signs of an allergic reaction: hives; dizziness; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about oral sodium biphosphate and sodium phosphate?

You should not use this medicine if you have kidney disease, a bowel obstruction, a perforated bowel, colitis or toxic megacolon, or a history of gastric bypass surgery or stomach stapling.

In rare cases, this medicine can cause kidney failure, especially if you have: kidney disease, congestive heart failure, severe constipation, inflammatory bowel disease, if you are over 55, or if you are dehydrated. Using certain other medicines can also increase your risk of kidney problems.

What should I discuss with my healthcare provider before taking oral sodium biphosphate and sodium phosphate?

You should not use oral sodium biphosphate and sodium phosphate if you are allergic to it, or if you have:

  • kidney disease (or if you have ever had a biopsy showing a kidney problem caused by too much phosphate);
  • a bowel obstruction;
  • a perforated bowel;
  • colitis or toxic megacolon; or
  • a history of gastric bypass surgery or stomach stapling.

In rare cases, this medicine can cause kidney failure, especially if:

Do not use Osmoprep if you have already used it within the past 7 days.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

Ask a doctor before using this medicine if you are pregnant or breast-feeding.

Do not give this medicine to a child without medical advice.

How should I take oral sodium biphosphate and sodium phosphate?

Use exactly as directed on the label, or as prescribed by your doctor.

Using too much of this medicine can cause rare but life-threatening side effects on your kidneys and heart.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

To keep from getting dehydrated, drink plenty of water or other clear liquid before, during, and after taking this medicine. Avoid milk, liquids that are colored red or purple, juice that contains pulp, or drinks that contain alcohol.

Carefully follow your doctor's dosing instructions about the timing of this medication and your procedure.

You may need to follow a special diet while treating constipation or preparing for your colonoscopy. Follow your doctor's instructions about any restrictions on food or beverages.

Store at room temperature away from moisture and heat. Throw away any leftover medicine after your treatment ends.

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What happens if I miss a dose?

Call your doctor for instructions if you miss a dose or do not finish all doses required before your colonoscopy.

Do not use more than the recommended dose of this medicine in any 24-hour period.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using oral sodium biphosphate and sodium phosphate?

Do not use other laxatives or enemas.

Sodium biphosphate and sodium phosphate can make it harder for your body to absorb other medicines you take by mouth. Avoid taking oral medicines within 1 hour before or after you take sodium biphosphate and sodium phosphate.

What other drugs will affect oral sodium biphosphate and sodium phosphate?

Ask a doctor or pharmacist before using sodium biphosphate and sodium phosphate with any other medications, especially:

This list is not complete. Other drugs may affect sodium biphosphate and sodium phosphate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about sodium biphosphate and sodium phosphate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/24/2019

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