sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)

Brand Names: Kalexate, Kayexalate, Kionex

Generic Name: sodium polystyrene sulfonate

What is sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

Sodium polystyrene sulfonate binds itself to potassium in your digestive tract. This helps prevent your body from absorbing too much potassium.

Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia.

Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream.

Sodium polystyrene sulfonate may also be used for purposes not listed in this medication guide.

What are the possible side effects of sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sodium polystyrene sulfonate and call your doctor at once if you have:

  • stomach pain, rectal pain;
  • severe constipation, severe stomach pain, bloating;
  • fever, chills, vomiting;
  • confusion, thinking problems, feeling irritable;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

You should not use this medicine if you have low potassium levels or a bowel obstruction.

Do not give this medicine orally (by mouth) to a newborn baby.

Avoid taking other medicines by mouth within 3 hours before or 3 hours after you take sodium polystyrene sulfonate (or 6 hours before/after if you have slow digestion).

What should I discuss with my healthcare provider before using sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

You should not use sodium polystyrene sulfonate if you are allergic to it, or if you have:

  • low potassium levels (hypokalemia); or
  • a bowel obstruction.

Tell your doctor if you have ever had:

  • heart disease or high blood pressure;
  • a weak immune system caused using certain medicine;
  • severe constipation or other bowel problems;
  • kidney disease (or if you are on dialysis);
  • an electrolyte imbalance (such as low levels of potassium, calcium, or magnesium in your blood);
  • fluid retention;
  • severe burns;
  • a bowel disorder, or surgery on your intestines;
  • if you are dehydrated; or
  • if you are on a low-salt diet.

Because sodium polystyrene sulfonate is not absorbed into the bloodstream, this medicine is not expected to be harmful during pregnancy or while nursing a baby. Tell your doctor if you are pregnant or breast-feeding.

How is sodium polystyrene sulfonate given (Kalexate, Kayexalate, Kionex)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Sodium polystyrene sulfonate can be given as a liquid by mouth, through a stomach feeding tube, or as a rectal enema.

Do not give this medicine orally (by mouth) to a newborn baby. Do not use the medicine orally or rectally in a baby who has slow digestion caused by surgery or by using other medicines.

To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. Avoid inhaling the oral powder while you are preparing a dose.

Do not mix the powder with any juice or other liquid that contains potassium, such as orange juice.

The rectal enema form of this medicine is usually given by a healthcare professional. The enema will be inserted slowly while you are lying down. You may need to hold in the enema for up to several hours. The sodium polystyrene sulfonate enema is usually followed with a second cleansing enema.

You will need frequent medical tests to help your doctor determine how long to treat you with sodium polystyrene sulfonate.

Keep using this medicine even if you feel fine. Hyperkalemia often has no symptoms that you will notice until your potassium levels are very low.

Store at room temperature away from moisture and heat.


What is hemophilia? See Answer

What happens if I miss a dose (Kalexate, Kayexalate, Kionex)?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose (Kalexate, Kayexalate, Kionex)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

Avoid using antacids or laxatives without your doctor's advice. Antacids or laxatives can make sodium polystyrene sulfonate less effective, or cause serious side effects.

Do not use potassium supplements, calcium supplements, or salt substitutes while you are taking sodium polystyrene sulfonate, unless your doctor has told you to.

Avoid eating or drinking anything that contains sorbitol (a fruit sugar often used as a sweetener in chewing gum, diet drinks, baked goods, or frozen desserts).

What other drugs will affect sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)?

Sodium polystyrene sulfonate can make it harder for your body to absorb medicines you take by mouth. Avoid taking other medicines within 3 hours before or 3 hours after you take sodium polystyrene sulfonate.

  • If you have a condition that slows your digestion, avoid taking other medicines by mouth within 6 hours before or 6 hours after you take sodium polystyrene sulfonate.

Tell your doctor about all your other medicines. Some may affect sodium polystyrene sulfonate, especially:

  • digoxin, digitalis;
  • lithium;
  • thyroxine; or
  • drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection.

This list is not complete. Other drugs may affect sodium polystyrene sulfonate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Kalexate, Kayexalate, Kionex)?

Your doctor or pharmacist can provide more information about sodium polystyrene.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Health Solutions From Our Sponsors

Reviewed on 10/12/2022

Health Solutions From Our Sponsors