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sofosbuvir, velpatasvir, and voxilaprevir (Vosevi)

Brand Names: Vosevi

Generic Name: sofosbuvir, velpatasvir, and voxilaprevir

What is sofosbuvir, velpatasvir, and voxilaprevir (Vosevi) (Vosevi)?

Sofosbuvir, velpatasvir, and voxilaprevir (Vosevi) is a combination antiviral medicine that is used to treat chronic hepatitis C in adults.

Vosevi treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Vosevi is sometimes used in people who also have HIV. Vosevi is not a treatment for HIV or AIDS.

Vosevi may also be used for purposes not listed in this medication guide.

What are the possible side effects of Vosevi (Vosevi)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have new or worsening symptoms such as:

If you also take a heart rhythm medicine called amiodarone: Taking amiodarone with Vosevi can cause dangerous side effects on your heart. Get medical help right away if you take these medicines and you have:

  • very slow heartbeats, chest pain, shortness of breath;
  • confusion, memory problems; or
  • weakness, extreme tiredness, light-headed feeling (like you might pass out).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sofosbuvir, velpatasvir, and voxilaprevir (Vosevi)?

If you have ever had hepatitis B, this medicine can cause the condition to come back or get worse. You will need frequent blood tests to check your liver function.

Sofosbuvir, velpatasvir, and voxilaprevir is sometimes used in combination with other medication. Read the medication guide or patient instructions provided with each medication in your combination therapy.

What should I discuss with my healthcare provider before taking Vosevi (Vosevi)?

You should not use this medicine if you are allergic to sofosbuvir, velpatasvir, or voxilaprevir.

If you take Vosevi with other antiviral medicines: There may be other reasons you should not take this combination treatment. Tell your doctor about all your medical conditions.

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I take Vosevi (Vosevi)?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using this medicine.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Vosevi is usually taken once per day for 12 weeks.

Take this medicine with food, at the same time each day.

You will need frequent blood tests to check your liver function.

If you've ever had hepatitis B, using Vosevi can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

You should not stop using Vosevi suddenly. Stopping suddenly could make your hepatitis C harder to treat with antiviral medicine.

Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with chronic hepatitis C should remain under the care of a doctor.

Store this medicine in the original container at room temperature away from moisture and heat.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

What happens if I miss a dose (Vosevi)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose (Vosevi)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Vosevi (Vosevi)?

If you also take an antacid, do not take it for at least 4 hours after you have taken your dose of Vosevi (with food).

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect Vosevi (Vosevi)?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect sofosbuvir, velpatasvir, and voxilaprevir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Vosevi)?

Your pharmacist can provide more information about sofosbuvir, velpatasvir, and voxilaprevir (Vosevi).


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/24/2019

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