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naproxen and sumatriptan (Treximet)

Brand Names: Treximet

Generic Name: naproxen and sumatriptan

What is naproxen and sumatriptan (Treximet)?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Sumatriptan is a migraine headache medicine.

Naproxen and sumatriptan is a combination medicine used to treat migraine headaches. This medicine will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Naproxen and sumatriptan should not be used to treat cluster headaches or any headache that causes loss of movement on one side of your body.

Naproxen and sumatriptan may also be used for purposes not listed in this medication guide.

What are the possible side effects of naproxen and sumatriptan (Treximet)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and seek emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using this medicine and call your doctor at once if you have:

  • numbness, tingling, pale or blue-colored appearance in your fingers or toes;
  • leg cramps, burning, coldness, or heavy feeling in your feet or legs;
  • severe headache, blurred vision, pounding in your neck or ears;
  • a seizure;
  • heart problems--swelling, rapid weight gain, feeling short of breath;
  • high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • stomach problems--sudden severe stomach pain (especially after eating), vomiting, constipation, bloody diarrhea, weight loss.

Common side effects may include:

  • dizziness, drowsiness, feeling weak or tired;
  • irregular heartbeats;
  • numbness or tingling in your fingers or toes;
  • dry mouth, heartburn, nausea;
  • feeling hot; or
  • tight muscles, pain or pressure in your chest or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about naproxen and sumatriptan (Treximet)?

You should not use this medicine if you have heart problems, uncontrolled high blood pressure, blood circulation problems, Wolff-Parkinson-White Syndrome, a history of heart attack or stroke, severe liver disease, a history of severe allergic reaction to aspirin or an NSAID, or if you are in late pregnancy.

Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine.

What should I discuss with my healthcare provider before taking naproxen and sumatriptan (Treximet)?

You should not use this medicine if you are allergic to naproxen (Aleve, Anaprox, Naprosyn) or sumatriptan (Imitrex), or if you have:

  • heart problems, uncontrolled high blood pressure;
  • a history of heart attack or stroke (including TIA or "mini-stroke");
  • Wolff-Parkinson-White Syndrome (sudden fast heartbeats) or other heart rhythm disorder;
  • blood circulation problems (including poor blood flow to your arms and legs, stomach, intestines, or kidneys);
  • a history of asthma or severe allergic reaction after taking aspirin or an NSAID;
  • severe liver disease; or
  • if you are in late pregnancy.

Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen and sumatriptan, especially in older adults.

Do not use naproxen and sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine, including:

Tell your doctor if you have ever had:

Taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while you are taking this medicine.

Naproxen and sumatriptan is not approved for use by anyone younger than 12 years old.

How should I take naproxen and sumatriptan (Treximet)?

Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition. Overuse of migraine headache medicine can actually make your headaches worse.

Take 1 tablet as soon as you notice headache symptoms, or after an attack has already begun. You may take the medicine with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

If your headache does not go away, call your doctor before taking a second tablet. If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first.

If you are 12 to 17 years old: Do not take a second tablet without first asking your doctor.

You must wait at least 2 hours before you take a second tablet. Do not take more than 2 tablets in 24 hours. If your symptoms have not improved, call your doctor before taking any more tablets.

You should not use this medicine to treat more than 5 headaches in 30 days (or more than 2 headaches in 30 days if you are 12 to 17 years old).

Store at room temperature away from moisture and heat.

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What happens if I miss a dose (Treximet)?

Since naproxen and sumatriptan is taken only when needed, it does not have a daily dosing schedule. Do not take more than 2 tablets in 24 hours.

What happens if I overdose (Treximet)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking naproxen and sumatriptan (Treximet)?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin or other salicylates such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).

What other drugs will affect naproxen and sumatriptan (Treximet)?

Ask your doctor before using naproxen and sumatriptan if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect naproxen and sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Treximet)?

Your pharmacist can provide more information about naproxen and sumatriptan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 9/9/2020

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