tafenoquine (Arakoda, Krintafel)

Brand Names: Arakoda, Krintafel

Generic Name: tafenoquine

What is tafenoquine (Arakoda, Krintafel)?

Tafenoquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Tafenoquine is used to treat malaria in people who are also using other anti-malaria medications.

Tafenoquine may also be used for purposes not listed in this medication guide.

What are the possible side effects of tafenoquine (Arakoda, Krintafel)?

Get emergency medical help if you have signs of an allergic reaction: hives; dizziness, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pale or yellowed skin, dark colored urine;
  • darkening of your mouth, lips, or fingernails;
  • feeling light-headed or short of breath;
  • confusion, tiredness; or
  • new or worsening mental health problems--anxiety, strange dreams, trouble sleeping.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tafenoquine (Arakoda, Krintafel)?

You should not use this medicine if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Your doctor will perform a test to make sure you do not have this condition.

What should I discuss with my healthcare provider before taking tafenoquine (Arakoda, Krintafel)?

You should not use tafenoquine if:

  • you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; or
  • you are allergic to tafenoquine or similar medicines (such as primaquine).

Do not breast-feed while using tafenoquine, if your baby has G6PD deficiency (or has not been tested for it). If the baby does have G6PD deficiency, you should also not breast-feed for at least 3 months after your last dose of tafenoquine.

You may need to have a negative pregnancy test before starting this treatment.

Do not use tafenoquine if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

Tell your doctor right away if you become pregnant.

Tell your doctor if you have ever had:

Tafenoquine is not approved for use by anyone younger than 16 years old.

How should I take tafenoquine (Arakoda, Krintafel)?

Before you take this medicine, your doctor will perform a test to make sure you do not have G6PD deficiency.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Start taking tafenoquine on the first or second day you start your other anti-malaria medication.

Take with food.

Swallow the tablet whole and do not crush, chew, or break it.

If you vomit within 1 hour after taking tafenoquine, call your doctor to ask if you should take another dose or wait until your next scheduled dose time.

Use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

Call your doctor as soon as possible if you have been exposed to malaria, or if you have fever, vomiting, or diarrhea during or after a stay in an area where malaria is common.

No medication is 100% effective in treating or preventing all types of malaria. For best results, keep using the medication as directed.

Store at room temperature away from moisture and heat.

Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.


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What happens if I miss a dose (Arakoda, Krintafel)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Arakoda, Krintafel)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking tafenoquine (Arakoda, Krintafel)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect tafenoquine (Arakoda, Krintafel)?

Other drugs may affect tafenoquine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Arakoda, Krintafel)?

Your pharmacist can provide more information about tafenoquine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 11/15/2021

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