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Medications and Drugs

Brand Names: Navane

Generic Name: thiothixene (Pronunciation: THYE oh THIX een)

What is thiothixene (Navane)?

Thiothixene is an antipsychotic medication. It affects the actions of chemicals in your brain.

Thiothixene is used to treat schizophrenia.

Thiothixene may also be used for purposes not listed in this medication guide.

Thiothixene 1 mg-MYL

capsule, blue/brown, imprinted with MYLAN 1001

Thiothixene 10 mg-MYL

capsule, brown/orange, imprinted with MYLAN 5010

Thiothixene 2 mg-MYL

capsule, brown/yellow, imprinted with MYLAN 2002

Thiothixene 5 mg-MYL

capsule, brown/white, imprinted with MYLAN 3005

What are the possible side effects of thiothixene (Navane)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking thiothixene and call your doctor at once if you have a serious side effect such as:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking);
  • trouble swallowing;
  • vision changes;
  • swelling in your hands or feet;
  • seizure (convulsions);
  • pale skin, easy bruising or bleeding, unusual weakness; or
  • fever, chills, body aches, flu symptoms.

Less serious side effects may include:

  • dizziness or drowsiness;
  • feeling restless or agitated;
  • sleep problems (insomnia);
  • breast swelling or discharge;
  • changes in your menstrual periods;
  • nausea, vomiting, diarrhea, constipation;
  • changes in weight or appetite;
  • dry mouth, increased thirst; or
  • impotence, loss of interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about thiothixene (Navane)?

Thiothixene is not for use in psychotic conditions related to dementia. Thiothixene may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medication if you are allergic to thiothixene, or if you have a blood cell disorder such as anemia or low white blood cells or platelets, or if you have decreased alertness caused by taking certain medications or drinking alcohol.

Call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Thiothixene may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not drink alcohol. Thiothixene can increase the effects of alcohol, which could be dangerous.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Thiothixene can decrease perspiration and you may be more prone to heat stroke.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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