trazodone (Desyrel, Desyrel Dividose)

Brand Names: Desyrel, Desyrel Dividose

Generic Name: trazodone

• What is trazodone (Desyrel, Desyrel Dividose)?
• What are the possible side effects of trazodone (Desyrel, Desyrel Dividose)?
• What is the most important information I should know about trazodone (Desyrel, Desyrel Dividose)?
• What should I discuss with my healthcare provider before taking trazodone (Desyrel, Desyrel Dividose)?
• How should I take trazodone (Desyrel, Desyrel Dividose)?
• What happens if I miss a dose (Desyrel, Desyrel Dividose)?
• What happens if I overdose (Desyrel, Desyrel Dividose)?
• What should I avoid while taking trazodone (Desyrel, Desyrel Dividose)?
• What other drugs will affect trazodone (Desyrel, Desyrel Dividose)?
• Where can I get more information (Desyrel, Desyrel Dividose)?

Trazodone is an antidepressant that is used to treat major depressive disorder.

Trazodone may also be used for purposes not listed in this medication guide.

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Desyrel 150 mg

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Trazodone 100 mg 683820806

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Trazodone 100 mg-BAR

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Trazodone 100 mg-SID

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Trazodone 100 mg-TEV

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Trazodone 100 mg-WAT

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Trazodone 150 mg 683820807

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Trazodone 300 mg 683820808

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trazodone 50 mg 009046868

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Trazodone 50 mg 683820805

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Trazodone 50 mg-BAR

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Trazodone 50 mg-MUT

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Trazodone 50 mg-TEV

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Trazodone 50 mg-WAT

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Trazodone HCl 100 mg 009046869

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
• slow heartbeats;
• unusual thoughts or behavior;
• easy bruising, unusual bleeding; or
• low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

• drowsiness, dizziness, tiredness;
• swelling;
• weight loss;
• blurred vision;
• diarrhea, constipation; or
• stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Trazodone is not approved for use by anyone younger than 18 years old.

You should not use trazodone if you are allergic to it.

Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you have ever had:

• liver or kidney disease;
• heart disease, or a recent heart attack;
• a bleeding or blood clotting disorder;
• seizures or epilepsy;
• narrow-angle glaucoma;
• long QT syndrome;
• drug addiction or suicidal thoughts; or
• bipolar disorder (manic depression).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with trazodone and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether trazodone will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Trazodone is not approved for use by anyone younger than 18 years old.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take trazodone after a meal or a snack.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using trazodone suddenly, or you could have unpleasant symptoms (such as dizziness, vomiting, agitation, sweating, confusion, numbness, tingling, or electric shock feelings). Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

QUESTION

Depression is a(n) __________ . See Answer

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with trazodone may cause you to bruise or bleed easily.

Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can affect trazodone, especially:

• any other antidepressants;
• phenytoin;
• St. John's wort;
• tramadol;
• a diuretic or "water pill";
• medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
• a blood thinner--warfarin, Coumadin, Jantoven; or
• migraine headache medicine--sumatriptan, Imitrex, Maxalt, Treximet, and others.

This list is not complete and many other drugs may affect trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Your pharmacist can provide more information about trazodone.

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