trilaciclib (Cosela)

Brand Names: Cosela

Generic Name: trilaciclib

What is trilaciclib (Cosela)?

Trilaciclib is used to help prevent bone marrow suppression in people receiving chemotherapy with certain medicines to treat small cell lung cancer.

Trilaciclib may also be used for purposes not listed in this medication guide.

What are the possible side effects of trilaciclib (Cosela)?

Get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing; swelling of your eyes, face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected;
  • fever, chills, cough with mucus;
  • sudden chest pain, wheezing, dry cough, feeling short of breath;
  • low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Your trilaciclib treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • low levels of calcium or potassium;
  • headache;
  • breathing problems;
  • feeling tired; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about trilaciclib (Cosela)?

Call your doctor at once if you have pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected.

What should I discuss with my healthcare provider before receiving trilaciclib (Cosela)?

You should not be treated with trilaciclib if you are allergic to it.

Tell your doctor if you have ever had liver problems.

Trilaciclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed while using trilaciclib and for at least 3 weeks after your last dose.

How is trilaciclib given (Cosela)?

Trilaciclib is given as an infusion into a vein, usually within 4 hours before the start of your chemotherapy infusion. A healthcare provider will give you this injection.

Trilaciclib must be given slowly, and the infusion can take at least 30 minutes to complete.


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What happens if I miss a dose (Cosela)?

Call your doctor for instructions if you miss an appointment for your trilaciclib injection.

What happens if I overdose (Cosela)?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving trilaciclib (Cosela)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect trilaciclib (Cosela)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect trilaciclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Cosela)?

Your pharmacist can provide more information about trilaciclib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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