tucatinib (Tukysa)

Brand Names: Tukysa

Generic Name: tucatinib

What is tucatinib (Tukysa)?

Tucatinib is used together with other medicines (trastuzumab and capecitabine) to treat HER2-positive breast cancer. This combination chemotherapy is used when the cancer has spread to other parts of the body or cannot be removed with surgery.

Tucatinib is usually given after other treatments have failed.

Tucatinib may also be used for purposes not listed in this medication guide.

What are the possible side effects of tucatinib (Tukysa)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tucatinib (Tukysa)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before taking tucatinib (Tukysa)?

Tell your doctor if you have ever had liver disease.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Tucatinib can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using tucatinib.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because tucatinib can harm an unborn baby.

Do not breastfeed while using tucatinib, and for at least 1 week after your last dose.

You may need to prevent pregnancy or avoid breastfeeding for longer periods of time after you stop using capecitabine or trastuzumab. Read all medication guides you receive. Follow directions about pregnancy or breastfeeding after you stop combination chemotherapy.

How should I take tucatinib (Tukysa)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take tucatinib with or without food.

Swallow the tablet whole and do not crush, chew, or break it. Do not use a cracked or broken tablet.

Take the medicine at the same time each day, about every 12 hours.

If you vomit shortly after taking tucatinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

You will need frequent blood tests to check your liver function.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Throw away any unused tucatinib tablets 3 months after you first opened the bottle.


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What happens if I miss a dose (Tukysa)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose (Tukysa)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking tucatinib (Tukysa)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect tucatinib (Tukysa)?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect tucatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Tukysa)?

Your pharmacist can provide more information about tucatinib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Reviewed on 11/15/2021

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