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Medications and Drugs

Brand Names: Abbokinase, Kinlytic

Generic Name: urokinase (Pronunciation: URE oh KYE nase)

What is urokinase (Abbokinase, Kinlytic)?

Urokinase is a man-made product developed using a protein that occurs naturally in the kidneys. Urokinase is a thrombolytic agent that works by dissolving blood clots.

Urokinase is used to treat blood clots in the lungs.

Urokinase may also be used for other purposes not listed in this medication guide.

What are the possible side effects of urokinase (Abbokinase, Kinlytic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection );
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden headache or problems with speech, vision, or balance;
  • fever, chills, flu symptoms, nausea, vomiting, back pain, or stomach pain;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite;
  • swelling, weight gain, feeling short of breath;
  • urinating less than usual or not at all;
  • red or purple discoloration of fingers or toes;
  • weak or shallow breathing, blue-colored lips or fingernails;
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure); or
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about urokinase (Abbokinase, Kinlytic)?

You should not use this medication if you are allergic to urokinase, or if you have internal bleeding, a brain tumor or aneurysm, hemophilia or other bleeding disorder, arterial hypertension, or if you have had a recent stroke, surgery, organ transplant, or medical emergency .

Before you receive urokinase, tell your doctor if you have liver or kidney disease, diabetes, heart problems, if you are pregnant or recently gave birth, a history of stroke or stomach bleeding.

Tell your caregivers at once if you have a serious side effect such as easy bruising or bleeding, blood in your stools, coughing up blood, chest pain, sudden problems with vision or speech, swelling, discoloration of your fingers or toes, severe stomach pain, weak or shallow breathing, fever, chills, or flu symptoms.

Before you receive urokinase, tell your doctor if you are using a blood thinner such as warfarin (Coumadin), aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), and others, or any medication used to prevent blood clots such as Kabikinase, Plavix, Ticlid, Persantine, Streptase, and others.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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