Brand Names: Zelboraf
Generic Name: vemurafenib
- What is vemurafenib (Zelboraf)?
- What are the possible side effects of vemurafenib (Zelboraf)?
- What is the most important information I should know about vemurafenib (Zelboraf)?
- What should I discuss with my healthcare provider before taking vemurafenib (Zelboraf)?
- How should I take vemurafenib (Zelboraf)?
- What happens if I miss a dose (Zelboraf)?
- What happens if I overdose (Zelboraf)?
- What should I avoid while taking vemurafenib (Zelboraf)?
- What other drugs will affect vemurafenib (Zelboraf)?
- Where can I get more information (Zelboraf)?
What is vemurafenib (Zelboraf)?
Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer).
Vemurafenib is used only if your cancer has a specific genetic marker (an abnormal "BRAF" gene). Your doctor will test you for this gene.
Vemurafenib may also be used for purposes not listed in this medication guide.
What are the possible side effects of vemurafenib (Zelboraf)?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Stop using vemurafenib and call your doctor at once if you have:
- skin changes--a new wart or lesion, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole;
- unusual thickening of tissues under the skin on the palms of your hands or the soles of your feet;
- a finger or fingers that feel tight or are bent inward;
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- eye problems--vision changes, eye pain or swelling, severe eye redness, small white or yellow patches on the surface of your eye; or
- liver problems--stomach pain (upper right side), nausea, vomiting, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- joint pain;
- feeling tired;
- hair loss;
- mild rash or itching;
- skin growths; or
- sunburn, increased sensitivity to sunlight.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about vemurafenib (Zelboraf)?
Many drugs can interact with vemurafenib. Tell your doctor about all your current medicines and any you start or stop using
What should I discuss with my healthcare provider before taking vemurafenib (Zelboraf)?
You should not use vemurafenib if you are allergic to it.
Tell your doctor if you have ever had:
- liver or kidney disease;
- heart problems;
- long QT syndrome (in you or a family member); or
- an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood).
Tell your doctor about all radiation treatments you are scheduled to receive, or have received in the past.
Using vemurafenib may increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
How should I take vemurafenib (Zelboraf)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take the medicine every 12 hours, with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking vemurafenib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
You will need frequent medical tests.
To make sure vemurafenib is not causing harmful effects, your skin condition will need to be checked often. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. You may also need eye exams. Your cancer treatments may be delayed based on the results of these tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Your doctor may want to check your skin for several months after you stop using vemurafenib. Visit your doctor regularly.
What happens if I miss a dose (Zelboraf)?
Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 4 hours. Do not use two doses at one time.
What happens if I overdose (Zelboraf)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking vemurafenib (Zelboraf)?
What other drugs will affect vemurafenib (Zelboraf)?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect vemurafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Where can I get more information (Zelboraf)?
Your pharmacist can provide more information about vemurafenib.
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