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Medications and Drugs

Brand Names: Accolate

Generic Name: zafirlukast (Pronunciation: za FIR loo kast)

What is zafirlukast (Accolate)?

Zafirlukast is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.

Zafirlukast is used to for chronic treatment of asthma, and to prevent asthma attacks in adults and children as young as 5 years old.

Do not give this medication to a child without a doctor's advice.

Zafirlukast may also be used for purposes not listed in this medication guide.

Accolate 10 mg

round, white, imprinted with ACCOLATE 10, ZENECA

Accolate 20 mg

round, white, imprinted with ACCOLATE 20, ZENECA

What are the possible side effects of zafirlukast (Accolate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening asthma symptoms;
  • new or worsening cough, fever, trouble breathing;
  • mood or behavior changes, anxiety, depression, sleep problems (insomnia);
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
  • nausea, pain in your upper stomach, loss of appetite, flu symptoms, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about zafirlukast (Accolate)?

Zafirlukast will not work fast enough to treat an asthma attack that has already begun. Use only a fast-acting inhalation medicine to treat an asthma attack. Talk with your doctor if any of your asthma medications do not seem to work as well in treating or preventing attacks.

It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after several weeks of treatment.

Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. If it seems like you need to use more of any of your medications in a 24-hour period, talk with your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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