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Enlarged Spleen (Splenomegaly) Topic Guide

Enlarged Spleen (Splenomegaly) Enlarged Spleen (Splenomegaly): Enlarged spleen (splenomegaly) is generally caused by another condition such as cancers, bacterial or viral infections, immune disorders, and blood disorders. The most common symptom of an enlarged spleen is abdominal pain and bloating. Treatment for an enarged spleen is targeted toward the cause.