Symptoms and Signs of Fatigue

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Medically Reviewed on 3/30/2019

Doctor's Notes on Fatigue

Fatigue is a nonspecific feeling of tiredness, lack of energy, or listlessness. It is a symptom that can accompany a wide variety of medical conditions. Possible medical causes of fatigue include infections, injury, malnutrition, inflammatory conditions, connective tissue disorders, disorders of bone and muscle, gastrointestinal problems and disorders, cancers, and psychological or emotional conditions, among others.

Signs and symptoms that can be associated with fatigue are as varied as the conditions that cause fatigue. Associated symptoms can include pain, weakness, joint pain, limited range of motion, headache, weight loss, enlarged lymph nodes, depression, agitation, anxiety, nausea, vomiting, and diarrhea. Specific infections associated with fatigue may cause sore throat, shortness of breath, cough, painful urination, blood in the urine, or enlargement of the tonsils, among other symptoms.

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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.