- What other names is Ginseng, Panax known by?
- What is Ginseng, Panax?
- Is Ginseng, Panax effective?
- How does Ginseng, Panax work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Ginseng, Panax.
Asian Ginseng, Asiatic Ginseng, Chinese Ginseng, Chinese Red Ginseng, Ginseng, Ginseng Asiatique, Ginseng Blanc, Ginseng Blanc de Corée, Ginseng Chinois, Ginseng Coréen, Ginseng Coréen Rouge, Ginseng de Corée, Ginseng Japonais, Ginseng Oriental, Ginseng Panax, Ginseng Radix Alba, Ginseng Root, Ginseng Rouge, Ginseng Sino-coréen, Ginseng Tibétain, Guigai, Hong Shen, Japanese Ginseng, Jen-Shen, Jinsao, Jintsam, Insam, Korean Ginseng, Korean Ginseng Root, Korean Panax, Korean Panax Ginseng, Korean Red Ginseng, Korean White Ginseng, Manchurian Ginseng, Mandragore de Chine, Ninjin, Ninzin, Oriental Ginseng, Panax Coréen, Panax Ginseng Blanc, Panax schinseng, Racine de Vie, Radix Ginseng Rubra, Red Chinese Ginseng, Red Ginseng, Red Kirin Ginseng, Red Korean Ginseng, Red Panax Ginseng, Ren Shen, Renshen, Renxian, Sang, Seng, Sheng Shai Shen, Tibetan Ginseng, White Ginseng, White Panax Ginseng.
Panax ginseng is a plant that grows in Korea, northeastern China, and far eastern Siberia. People use the root to make medicine. Do not confuse Panax ginseng with American ginseng, Siberian ginseng, or Panax pseudoginseng. See the separate listings for American Ginseng, Ashwaganda, Blue Cohosh, Canaigre, Codonopsis, Panax Pseudoginseng, and Siberian Ginseng.
Panax ginseng is taken by mouth to improve thinking, concentration, memory, Alzheimer's disease, work efficiency, physical stamina, preventing muscle damage from exercise, and athletic endurance.
Some people use Panax ginseng to help them cope with stress and as a general tonic for improving well-being. They sometimes call Panax ginseng an "adaptogen" when it's used in this way.
Panax ginseng is also used for depression, anxiety, general fatigue and chronic fatigue syndrome (CFS), multiple sclerosis, for boosting the immune system, and for fighting particular infections in a lung disease called cystic fibrosis. These infections are caused by a bacterium named Pseudomonas.
Other uses include treatment of anemia, chronic bronchitis, swine flu, prediabetes and diabetes, inflammation of the stomach lining (gastritis), fever, hangover, chronic obstructive pulmonary disease (COPD), HIV/AIDS, fertility problems and sexual dysfunction in men, to increase sexual arousal in women, and asthma.
Panax ginseng is also used for bleeding disorders, loss of appetite, vomiting, intestinal problems, gallstones, bad breath, fibromyalgia, sleeping problems (insomnia), nerve pain, joint pain, dizziness, headache, hearing loss, convulsions, disorders of pregnancy and childbirth, hot flashes due to menopause, common cold and flu, heart failure, high blood pressure, quality of life, wrinkled skin, and to slow the aging process.
There is some scientific evidence that fish oils might have other benefits for the heart. Fish oils seem to help to prevent a second heart attack if started within hours of the first attack and continued for a year. Fish oils might also lower blood pressure in some people who have high blood pressure.
However, fish oils do not help atherosclerosis or “hardening of the arteries.” They also do not seem to help for some other conditions people use them for such as gum infections, lupus, kidney or liver disease, or leg pain due to blood flow problems.
- Treating sun sensitivity in people who have a form of inherited blood disorder called "erythropoietic protoporphyria." Taking beta-carotene by mouth can reduce sensitivity to the sun in people with erythropoietic protoporphyria.
Likely Effective for...
- Irregular heartbeat (torsades de pointes). Giving magnesium intravenously (by IV) is helpful for treating a certain type of irregular heartbeat called torsades de pointes.
Possibly Effective for...
- Alzheimer's disease. Evidence shows that taking Panax ginseng root daily for 12 weeks can improve mental performance in people with Alzheimer's disease.
- Lung disease called chronic obstructive pulmonary disease (COPD). Taking Panax ginseng by mouth seems to improve lung function and some symptoms of COPD.
- Mental function. Taking Panax ginseng by mouth might improve abstract thinking, mental arithmetic skills, and reaction times in healthy, middle-aged people but not in young adults. Panax ginseng alone does not seem to improve memory. But there is some evidence that a combination of Panax ginseng and ginkgo leaf extract can improve memory in otherwise healthy people between the ages of 38 and 66.
- Erectile dysfunction (ED). Taking Panax ginseng by mouth seems to improve sexual function in men with erectile dysfunction.
- Flu. Taking a specific Panax ginseng by mouth appears to reduce the risk of getting a cold or the flu. But, taking Panax ginseng does not seem to reduce flu symptoms or the length of the illness.
- Multiple sclerosis-related fatigue. Taking Panax ginseng daily for 3 months reduces feelings of tiredness and improves quality of life in females with MS.
- Premature ejaculation. Applying a cream containing Panax ginseng, angelica root, Cistanches deserticola, Zanthoxyl species, torlidis seed, clover flower, asiasari root, cinnamon bark, and toad venom (SS Cream) to the penis one hour before intercourse and washing off immediately before intercourse seems to help prevent premature ejaculation.
- Sexual arousal. Taking powdered Korean red ginseng, a specific form of Panax ginseng, seems to improve sexual arousal and satisfaction in postmenopausal women. Also, using a specific product containing Korean red ginseng and other ingredients (ArginMax for Women, Daily Wellness Company) seems to improve sexual desire in women who report sexual problems.
Possibly Ineffective for...
- Athletic performance. Taking Panax ginseng by mouth for up to 8 weeks does not improve exercise performance.
Likely Ineffective for...
- Cancer. Most research shows that taking beta-carotene does not prevent or decrease death from uterine cancer, cervical cancer, thyroid cancer, bladder cancer, skin cancers, brain cancer, or blood cancer (leukemia). However, some research suggests a combination of beta-carotene with vitamin C, vitamin E, selenium, and zinc might lower cancer rates in men, but not women. Researchers speculate that men have lower intake of dietary antioxidants and therefore might benefit more from supplements.
- Heart disease. A Science Advisory from the American Heart Association states that the evidence does not justify use of antioxidants such as beta-carotene for reducing the risk of heart disease. Evidence also shows that beta-carotene in combination with vitamin C and E does not decrease heart disease risk.
- Colon cancer. Most research shows that taking beta-carotene by mouth, alone or with vitamins C and E, selenium, and calcium carbonate, does not decrease the risk of colon tumor growth. It also doesn't seem to reduce the risk of colon tumor recurrence in people who have had colon tumors removed, although it might reduce the risk of colon tumor recurrence in people who never drink or smoke. However, in people that smoke cigarettes and drink alcohol, taking beta-carotene supplements increases the risk of new tumors. It is unclear if dietary beta-carotene reduces the risk of colon cancer.
- Lung cancer. Taking beta-carotene seems to increase the risk of lung cancer in people who smoke, people who used to smoke, people exposed to asbestos, and those who use alcohol in addition to smoking. However, beta-carotene from food does not seem to have this adverse effect. Taking supplements containing beta-carotene, vitamin E, and selenium for about 5 years does not reduce the risk of death in people previously diagnosed with lung cancer.
- Prostate cancer. Taking beta-carotene supplements does not prevent prostate cancer in most men. In fact, there is some concern that beta-carotene supplements might actually increase the risk of prostate cancer in some men. There is evidence that men who take a multivitamin daily along with a separate beta-carotene supplement have an increased risk of developing advanced prostate cancer. Also, men who smoke and take beta-carotene supplements have in increased risk of developing prostate cancer.
- Dementia related to Alzheimer's disease or other causes. Taking lecithin alone or with tacrine or ergoloids does not seem to improve mental abilities in people with dementia. It also doesn't seem to slow the progression of Alzheimer's disease.
Insufficient Evidence to Rate Effectiveness for...
- Age-related memory loss. Taking a specific product containing Panax ginseng and other ingredients (Memo, Pharco Pharmaceuticals) by mouth for 4 weeks improves memory in elderly people with some mental impairment.
- Breast cancer. Research conducted in China suggests that some people with breast cancer treated with any form of ginseng (American or Panax) have a higher quality of life and lower risk of death. However, this might not be a result of taking the ginseng. The people in the study were also likely to be treated with the prescription anticancer drug tamoxifen. It is difficult to know how much of the benefit to attribute to ginseng.
- Infection of the airways in the lung (bronchitis). Taking a specific Panax ginseng extract (G115) by mouth, combined with antibiotics, might be more effective in killing bacteria in the lungs of people with long-term bronchitis than antibiotic treatment alone.
- Cancer. Research suggests that taking ginseng by mouth might decrease the occurrence of some types of cancer, including stomach cancer, lung cancer, liver cancer, ovarian cancer, and skin cancer. However, other research shows that Panax ginseng doesn't reduce the risk of getting cancer. But several studies show that Panax ginseng might slow cancer growth and improve quality of life in cancer patients.
- Common cold. There is some evidence that taking a specific Panax ginseng extract (G115) by mouth can decrease the chance of catching a cold.
- Heart failure. Taking Panax ginseng by mouth daily, without or without conventional medications, seems to improve heart function.
- Diabetes. There is inconsistent evidence about the effects of Panax ginseng on diabetes. Some research shows that taking Panax ginseng by mouth daily can improve blood sugar levels. However, other research suggests that taking Panax ginseng (AIPOP, Gangdown-Do, Korea) or Korean red ginseng, a type of Panax ginseng, by mouth does not improve blood sugar levels in people with diabetes.
- Fatigue. Research suggests that taking Panax ginseng daily for 4 weeks reduces some, but not all, symptoms of fatigue.
- Fibromyalgia. Research suggests that taking Panax ginseng root extract by mouth daily for 12 weeks does not improve pain, tiredness, sleep quality, anxiety, tender points, or quality of life in people with fibromyalgia.
- Gallbladder disease. Research suggests that taking Panax ginseng together with medication for 24 weeks does not reduce gallstones.
- Bad breath. Early research suggests that taking Korean red ginseng, a type of Panax ginseng, daily for 10 weeks helps reduce bad breath. This is especially true in people with stomach ulcers from H. pylori infection.
- Hangover. Research suggests that drinking a beverage containing Panax ginseng extract within 5 minutes of drinking alcohol and eating a piece of cheese might lower blood alcohol levels and reduce hangover symptoms.
- Hearing loss. Early research suggests that taking Panax ginseng for 14 days reduces temporary hearing loss caused by loud noise. But it might be less effective than N-acetyl cysteine at preventing temporary hearing loss caused by loud noise.
- HIV. Early evidence shows that Korean red ginseng, a type of Panax ginseng, might increase immune function. But it does not affect how much of the HIV virus is circulating in the blood of people with HIV.
- High blood pressure. There is inconsistent evidence about the effects of Panax ginseng on blood pressure in people with high blood pressure. Some early research shows that taking Panax ginseng in three divided doses daily for 8 weeks slightly reduces blood pressure in people with high blood pressure. But taking a specific Panax ginseng product (Ginseol K-g1) daily for 8 weeks does not reduce blood pressure in people with mildly high blood pressure.
- Prediabetes. Taking a combination of Korean red ginseng and cheonggukjang, a type of fermented soybean paste, can reduce pre-meal blood sugar levels in people with prediabetes. Also taking fermented Panax ginseng can reduce post-meal blood sugar levels and increase post-meal insulin levels in people with prediabetes.
- Male infertility. Swollen prostate caused by Chlamydia infection is associated with reduced male fertility. Early research suggests that taking a specific product containing Panax ginseng (Fertimev) along with an antibiotic improves sperm concentration and sperm movement in people with swollen prostate caused by Chlamydia.
- Memory. Taking a specific Panax ginseng extract (G115) together with vitamins, minerals, and dimethylaminoethanol bitartrate might improve memory in people with memory problems.
- Menopausal symptoms. Panax ginseng seems to improve some, but not all, symptoms associated with menopause. Some early research suggests that Panax ginseng might improve quality of life and menopausal symptoms, such as fatigue, insomnia, and depression in postmenopausal women. Panax ginseng also seems to reduce cholesterol levels in postmenopausal women. There are mixed results regarding whether Panax ginseng reduces hot flashes. Panax ginseng does not appear to improve memory or concentration in postmenopausal women.
- Quality of life. While some research suggests that Panax ginseng might improve quality of life, other research shows no benefit.
- Wrinkled skin. Early research shows that taking a combination of Korean red ginseng root with Torilus fructus and Corni fructus daily for 24 weeks might reduce wrinkles. But it does not appear to affect skin moisture, elasticity, thickness, or color.
- Fluid retention.
- Stomach inflammation and other digestive problems.
- Chronic fatigue syndrome (CFS).
- Swine flu.
- Sleeping problems (insomnia).
- Disorders of pregnancy and childbirth.
- Bleeding disorders.
- Loss of appetite.
- Nerve pain.
- Joint pain.
- Other conditions.
Panax ginseng contains many active substances. The substances thought to be most important are called ginsenosides or panaxosides. Ginsenosides is the term coined by Asian researchers, and the term panaxosides was chosen by early Russian researchers.
Panax ginseng is often referred to as a general well-being medication, because it affects many different systems of the body.
Panax ginseng is POSSIBLY SAFE when applied to the skin as part of a multi-ingredient product (SS Cream), in the short-term.
Panax ginseng is POSSIBLY UNSAFE when taken by mouth, long-term (more than 6 months). Researchers think it may have some hormone-like effects that could be harmful with prolonged use.
The most common side effect is trouble sleeping (insomnia). Less commonly, people experience menstrual problems, breast pain, increased heart rate, high or low blood pressure, headache, loss of appetite, diarrhea, itching, rash, dizziness, mood changes, vaginal bleeding, and other side effects.
Uncommon side effects that have been reported include severe rash called Stevens-Johnson syndrome, liver damage, and severe allergic reactions.
Special Precautions & Warnings:Pregnancy and breast-feeding: Panax ginseng is POSSIBLY UNSAFE when taking by mouth during pregnancy. One of the chemicals in Panax ginseng has been found to cause birth defects in animals. Do not use Panax ginseng if you are pregnant.
Not enough is known about the safety of Panax ginseng during breast-feeding. Stay on the safe side and avoid use.
Infants and children: Panax ginseng is LIKELY UNSAFE in infants and children. Using Panax ginseng in babies has been linked to poisoning that can be fatal. The safety of Panax ginseng in older children is not known. Until more is known, do not use Panax ginseng even in older children.
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Panax ginseng seems to increase the activity of the immune system. It might make auto-immune diseases worse. Don't use Panax ginseng if you have any auto-immune condition.
Bleeding conditions: Panax ginseng seems to interfere with blood clotting. Don't use Panax ginseng if you have a bleeding condition.
Heart conditions: Panax ginseng can affect heart rhythm and blood pressure slightly on the first day it is used. However, there are usually no changes with continued use. Nevertheless, Panax ginseng has not been studied in people with cardiovascular disease. Use Panax ginseng with caution if you have heart disease.
Diabetes: Panax ginseng might lower blood sugar. In people with diabetes who are taking medications to lower blood sugar, adding Panax ginseng might lower blood sugar too much. Monitor your blood sugar closely if you have diabetes and use Panax ginseng.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Panax ginseng contains chemicals (ginsenosides) that can act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Panax ginseng.
Trouble sleeping (insomnia): High doses of Panax ginseng have been linked with insomnia. If you have trouble sleeping, use Panax ginseng with caution.
Organ transplant: Panax ginseng might make the immune system more active. This could interfere with the effectiveness of medications that are given after an organ transplant to reduce the chance that the organ will be rejected. If you have received an organ transplant, don't use Panax ginseng.
Schizophrenia (a mental disorder): High doses of Panax ginseng have been linked with sleep problems and agitation in people with schizophrenia. Be careful when using Panax ginseng if you have schizophrenia.
Organ transplant: Panax ginseng might make the immune system more active. This could interfere with the effectiveness of medications that are given after an organ transplant to reduce the chance that the organ will be rejected. If you have received an organ transplant, don't use Panax ginseng.
AlcoholInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down alcohol to get rid of it. Taking Panax ginseng might increase how fast your body gets rid of alcohol.
CaffeineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Caffeine can speed up the nervous system. By speeding up the nervous system, caffeine can make you feel jittery and speed up your heartbeat. Panax ginseng might also speed up the nervous system. Taking Panax ginseng along with caffeine might cause serious problems, including increased heart rate and high blood pressure. Avoid taking caffeine along with Panax ginseng.
EstrogensInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might have some of the same effects as estrogen. However, Panax ginseng is not as strong as estrogen pills. Taking Panax ginseng along with estrogen pills might decrease the effects of estrogen pills.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Furosemide (Lasix)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some scientists think that Panax ginseng might decrease how well furosemide (Lasix) works. But there isn't enough information to know if this is a big concern.
Imatinib (Gleevec)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications, including imatinib, are changed and broken down by the liver. There is a report of liver toxicity in a 26 year-old man taking imatinib along with Panax ginseng. It is believed that Panax ginseng decreased how quickly the liver broke down this medication, increasing the effects and side effects of imatinib.
InsulinInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking Panax ginseng along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Panax ginseng might decrease how quickly the liver breaks down some medications. Taking Panax ginseng along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking Panax ginseng, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Panax ginseng might decrease how quickly the liver breaks down some medications. Taking Panax ginseng along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking Panax ginseng, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, cisapride (Propulsid), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), and numerous others.
Medications for depression (MAOIs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might stimulate the body. Some medications used for depression can also stimulate the body. Taking Panax ginseng with these medications used for depression might cause too much stimulation. This might cause side effects such as anxiousness, headache, restlessness, and insomnia.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking Panax ginseng along with diabetes medications could add to the effects of diabetic medications and lower blood sugar too much. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that can cause an irregular heartbeat (QT interval-prolonging drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng may cause an abnormal heartbeat when taken short-term. Taking Panax ginseng with drugs that can cause an irregular heartbeat might cause serious side effects, including heart rhythm problems (arrhythmias).
Some medications that affect the heartbeat include amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Pronestyl), quinidine, sotalol (Betapace), thioridazine (Mellaril), and many others.
Medications that decrease the immune system (Immunosuppressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng increases the immune system. By increasing the immune system, Panax ginseng might decrease the effectiveness of medications that decrease the immune system.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might slow blood clotting. Taking Panax ginseng along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, cilostazol (Pletal), clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Midazolam (Versed)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications, including midazolam, are changed and broken down by the liver. Panax ginseng might increase how quickly the liver breaks down midazolam. In theory, taking Panax ginseng along with midazolam may decrease the effects of midazolam.
Nifedipine (Procardia)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Panax ginseng might affect how much nifedipine is available in the body. Taking Panax ginseng along with nifedipine might increase the blood pressure lowering effects of nifedipine.
RaltegravirInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Raltegravir is a drug used to treat people with HIV. Raltegravir has been associated with liver toxicity in some people. Taking Panax ginseng with raltegravir might increase the risk of liver toxicity in some people taking raltegravir.
Stimulant drugsInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Panax ginseng might also speed up the nervous system. Taking Panax ginseng along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with Panax ginseng.
Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Warfarin (Coumadin) is used to slow blood clotting. There is some concern that Panax ginseng might decrease the effectiveness of warfarin (Coumadin). But it's not clear if this interaction is a big problem. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Fexofenadine (Allegra)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Fexofenadine is taken to treat seasonal allergies. When taken together with fexofenadine, Panax ginseng might reduce how much fexofenadine is available in the body. However, there isn't enough information to know if this is a big concern.
Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Panax ginseng might increase how quickly the liver breaks down some medications. Taking Panax ginseng along with some medications that are changed by the liver can decrease the effects and side effects of your medication. Before taking Panax ginseng, talk to your healthcare provider if you take any medications that are changed by the liver.
The following doses have been studied in scientific research:
- For Alzheimer's disease: 4.5 to 9 grams of Panax ginseng root daily for 12 weeks has been used.
- For chronic obstructive pulmonary disease (COPD): 100 mg to 6 grams of Panax ginseng three times daily for up to 3 months has been used.
- For mental function: 200 to 400 mg of a specific Panax ginseng extract (G115, Pharmaton SA, Lugano, Switzerland) taken once daily or in two divided doses for up to 12 weeks, or 200 to 960 mg as a single dose, has been used.
- For erectile dysfunction: 1400 to 2700 mg of Panax ginseng, taken in two or three divided doses per day for up to 12 weeks, has been used.
- For flu: 200 mg of Panax ginseng extract (G115) daily, starting 4 weeks before getting a flu shot and continuing for 8 weeks after, has been used. Also, 1 gram of Panax ginseng extract three times daily for 12 weeks has also been used.
- For multiple sclerosis-related fatigue: 250 mg of Panax ginseng twice daily for 3 months has been used.
- For sexual arousal: 3 grams of Korean red ginseng, a form of Panax ginseng, daily for 8 weeks has been used. A specific combination product (ArginMax for Women, The Daily Wellness Company), taken daily for 4 weeks, has also been used.
- For premature ejaculation: a cream (SS-Cream) containing Panax ginseng and other ingredients has been applied to the glans penis one hour before intercourse and washed off before intercourse.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Cai, T., Wagenlehner, F. M., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., Tiscione, D., Malossini, G., and Bartoletti, R. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. J Androl 2012;33(4):615-623. View abstract.
Gurley, B. J., Gardner, S. F., Hubbard, M. A., Williams, D. K., Gentry, W. B., Cui, Y., and Ang, C. Y. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging 2005;22(6):525-539. View abstract.
Ito, T. Y., Trant, A. S., and Polan, M. L. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther 2001;27(5):541-549. View abstract.
Kennedy DO, Scholey AB, and Wesnes KA. Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr.Neurosci. 2001;4(5):399-412. View abstract.
Kennedy, D. O., Haskell, C. F., Wesnes, K. A., and Scholey, A. B. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav 2004;79(3):401-411. View abstract.
Wesnes KA, Faleni RA, Hefting NR, and et al. The cognitive, subjective, and physical effects of a Ginkgo biloba/Panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacol Bull 1997;33(4):677-683. View abstract.
Abdel-Wahhab MA, Hassan NS, El-Kady AA, Khadrawy YA, El-Nekeety AA, Mohamed SR, Sharaf HA, Mannaa FA. Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats. Food Chem Toxicol 2010;48(2):733-42. View abstract.
Ahn CM, Hong SJ, Choi SC, Park JH, Kim JS, Lim DS. Red ginseng extract improves coronary flow reserve and increases absolute numbers of various circulating angiogenic cells in patients with first ST-segment elevation acute myocardial infarction. Phytother Res 2011;25(2):239-49. View abstract.
Ahn JY, Kim MH, Lim MJ, Park S, Lee SL, Yun YS, Song JY. The inhibitory effect of ginsan on TGF-ß mediated fibrotic process. J Cell Physiol 2011;226(5):1241-7. View abstract.
Ahn JY, Song JY, Yun YS, Jeong G, Choi IS. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol 2006;46(2):187-97. View abstract.
Allen JD, McLung J, Nelson AG, Welsch M. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance. J Am Coll Nutr 1998;17:462-6. View abstract.
An X, Zhang AL, Yang AW, et al. Oral ginseng formulae for chronic obstructive pulmonary disease: a systematic review. Resp Med 2011;105:165-76. View abstract.
Arbuzov, A. G., Maslov, L. N., Burkova, V. N., Krylatov, A. V., Konkovskaia, IuN, and Safronov, S. M. [Phytoadaptogens-induced phenomenon similar to ischemic preconditioning]. Ross Fiziol Zh Im I M Sechenova 2009;95(4):398-404. View abstract.
Baek SH, Lee JG, Park SY, Bae ON, Kim DH, Park JH. Pectic polysaccharides from Panax ginseng as the antirotavirus principals in ginseng. Biomacromolecules 2010;11(8):2044-52. View abstract.
Bai CX, Takahashi K, Masumiya H, Sawanobori T, Furukawa T. Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes. Br J Pharmacol 2004;142(3):567-75. View abstract.
Baravalle C, Dallard BE, Ortega HH, Neder VE, Canavesio VR, Calvinho LF. Effect of Panax ginseng on cytokine expression in bovine mammary glands at drying off. Vet Immunol Immunopathol 2010;138(3):224-30. View abstract.
Becker BN. Ginseng-induced diuretic resistance. JAMA 1996;276:606-7. View abstract.
Belogortseva NI, Yoon JY, Kim KH. Inhibition of Helicobacter pylori hemagglutination by polysaccharide fractions from roots of Panax ginseng. Planta Med 2000;66:217-20. View abstract.
Bilgi N, Bell K, Ananthakrishnan AN, Atallah E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother 2010;44(5):926-8. View abstract.
Braz AS, Morais LC, Paula AP, Diniz MF, Almeida RN. Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial. Rev Bras Psiquiatr 2013;35(1):21-8. View abstract.
Brown R. Potential interactions of herbal medicines with antipsychotics, antidepressants and hypnotics. Eur J Herbal Med 1997;3:25-8.
Cabral de Oliveira AC, Perez AC, Merino G, Prieto JG, Alvarez AI. Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comp Biochem Physiol C Toxicol Pharmacol 2001;130(3):369-77. View abstract.
Cardinal BJ, Engels HJ. Ginseng does not enhance psychological well-being in healthy, young adults: results of a double-blind, placebo-controlled, randomized clinical trial. J Am Diet Assoc 2001;101:655-60.. View abstract.
Caron MF, Hotsko AL, Robertson S, et al. Electrocardiographic and hemodynamic effects of Panax ginseng. Ann Pharmacother 2002;36:758-63.. View abstract.
Caso MA, Vargas RR, Salas VA, Begona IC. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res 1996;22:323-9. View abstract.
Chae S, Kang KA, Chang WY, Kim MJ, Lee SJ, Lee YS, Kim HS, Kim DH, Hyun JW. Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo. J Agric Food Chem 2009;57(13):5777-82. View abstract.
Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8.. View abstract.
Chang MS, Lee SG, Rho HM. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother Res 1999;13(8):641-4. View abstract.
Chen X, Lee TJ. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115(1):15-8. View abstract.
Chen X. Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol 1996;23(8):728-32. View abstract.
Cheng TO. Panax (ginseng) is not a panacea. Arch Intern Med 2000;160:3329. View abstract.
Cho J, Park W, Lee S, et al. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 2004;89:3510-5. View abstract.
Cho JY, Kim AR, Yoo ES, Baik KU, Park MH. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 2002;68(6):497-500. View abstract.
Cho SH, Chung KS, Choi JH, Kim DH, Lee KT. Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells. BMC Cancer 2009 Dec 18;9:449. View abstract.
Cho YK, Jung YS, Sung H, Sim MK, Kim YK. High frequency of gross deletions in 5' LTR/gag and nef genes in patients infected with CRF02_AG of HIV type 1 who survived for over 20 years: an association with Korean red ginseng. AIDS Res Hum Retroviruses 2009;25(5):535-41. View abstract.
Cho YK, Jung YS, Sung H. Frequent gross deletion in the HIV type 1 nef gene in hemophiliacs treated with Korean Red Ginseng: inhibition of detection by highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2009;25(4):419-24. View abstract.
Cho, S., Won, C. H., Lee, D. H., Lee, M. J., Lee, S., So, S. H., Lee, S. K., Koo, B. S., Kim, N. M., and Chung, J. H. Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study. J Med Food 2009;12(6):1252-1259. View abstract.
Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. View abstract.
Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995;7(3):181-6. View abstract.
Choi S, Kim TW, Singh SV. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res 2009;26(10):2280-8. View abstract.
Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study. Int J Impot Res 2013;25(2):45-50. View abstract.
Chow L, Johnson M, Wells A, Dasgupta A. Effect of the traditional Chinese medicines Chan Su, Lu-Shen-Wan, Dan Shen, and Asian ginseng on serum digoxin measurement by Tina-quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays. J Clin Lab Anal 2003;17:22-7. View abstract.
Chun, Y. H., Kim, K. R., and Rhe, B. Y. Effect of Korean Ginseng on teratogenicity of chlorambucil on developing fetal skeletogenesis in rats. Univ Med J 1982;19:455.
Cui Y, Shu XO, Gao YT, et al. Association of ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol 2006;163:645-53. View abstract.
Dasgupta A, Tso G, Wells A. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. J Clin Lab Anal 2008;22:295-301. View abstract.
Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. View abstract.
De Souza LR, Jenkins AL, Sievenpiper JL, Jovanovski E, Rahelic D, Vuksan V. Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: differential effects on postprandial glycemia in healthy individuals. J Ethnopharmacol 2011;137(1):245-50. View abstract.
Dega H, Laporte JL, Frances C, et al. Ginseng as a cause of Stevens-Johnson syndrome. Lancet 1996;347:1344. View abstract.
Deng J, Lv XT, Wu Q, Huang XN. Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Eur J Pharmacol 2009;608(1-3):42-7. View abstract.
Dharmananda S. The nature of ginseng: traditional use, modern use, and the question of dosage. Herbalgram 2002;54:34-51.
Ding DZ, Shen TK, Cui YZ. Effects of red ginseng on the congestive heart failure and its mechanism. Chung Kuo Chung His I Chieh Ho Tsa Chih 1995;15:325-7. View abstract.
Doosti A, Lotfi Y, Moossavi A, Bakhshi E, Talasaz AH, Hoorzad A. Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers. Noise Health 2014;16(71):223-7. View abstract.
Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother 2002;36:375-9. View abstract.
Engels HJ, Wirth JC. No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during grades maximal aerobic exercise. J Am Diet Assoc 1997;97:1110-5. View abstract.
Engels, H. J., Fahlman, M. M., and Wirth, J. C. Effects of ginseng on secretory IgA, performance, and recovery from interval exercise. Med Sci Sports Exerc 2003;35(4):690-696. View abstract.
Etemadifar M, Sayahi F, Abtahi SH, Shemshaki H, Dorooshi GA, Goodarzi M, Akbari M, Fereidan-Esfahani M. Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study. Int J Neurosci 2013;123(7):480-6. View abstract.
Fahim MS, Fahim Z, Harman JM, Clevenger TE, Mullins W, Hafez ES. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl 1982;8(4):261-3. View abstract.
Forgo, I., Kayasseh, L., and Staub, J. J. [Effect of a standardized ginseng extract on general well-being, reaction time, lung function and gonadal hormones]. Med Welt 5-8-1981;32(19):751-756. View abstract.
Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
Gonzalez-Seijo JC, Ramos YM, Lastra I. Manic episode and ginseng: Report of a possible case. J Clin Psychopharmacol 1995;15:447-8. View abstract.
Greenspan EM. Ginseng and vaginal bleeding [letter]. JAMA 1983;249:2018. View abstract.
Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87.. View abstract.
Gurley BJ, Gardner SF, Hubbard MA. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.
Hamid S, Rojter S, Vierling J. Protracted cholestatic hepatitis after the use of Prostata. Ann Intern Med 1997;127:169-70. View abstract.
Hammond TG, Whitworth JA. Adverse reactions to ginseng [letter]. Med J Aust 1981;1:492.. View abstract.
Han, K. H., Choe, S. C., Kim, H. S., Sohn, D. W., Nam, K. Y., Oh, B. H., Lee, M. M., Park, Y. B., Choi, Y. S., Seo, J. D., and Lee, Y. W. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 1998;26(2):199-209. View abstract.
Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Black seed seed (black cumin). J Ethnopharmacol 1991;34:275-8. View abstract.
Hao, M., Ba, Q., Yin, J., Li, J., Zhao, Y., and Wang, H. Deglycosylated ginsenosides are pG2 cells than glycosylated ginsenosides. Drug Metab Pharmacokinet. 12-17-2010. View abstract.
Hartley, D. E., Elsabagh, S., and File, S. E. Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr.Neurosci. 2004;7(5-6):325-333. View abstract.
He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, Zhou Q, Wang YT, Luu HH, Haydon RC, Wang CZ, Du W, Yuan CS, He TC, Zhang BQ. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß:-catenin signaling. Int J Oncol 2011;38(2):437-45. View abstract.
Heo, J. H., Lee, S. T., Chu, K., Oh, M. J., Park, H. J., Shim, J. Y., and Kim, M. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease. Eur.J Neurol. 2008;15(8):865-868. View abstract.
Hiai S, Yokoyama H, Oura H, et al. Stimulation of pituitary-adrenocortical system by ginseng saponin. Endocrinol Jpn 1979;26:661-5. View abstract.
Hien TT, Kim ND, Kim HS, Kang KW. Ginsenoside Rg3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. Pharmazie 2010;65(9):699-701. View abstract.
Hong B, Ji YH, Hong JH, et al. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3.. View abstract.
Hong BN, Kim SY, Yi TH, Kang TH. Post-exposure treatment with ginsenoside compound K ameliorates auditory functional injury associated with noise-induced hearing loss in mice. Neurosci Lett 2011;487(2):217-22. View abstract.
Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynecol 1988;159:1121-2. View abstract.
Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Drugs 2005;65(9):1239-1282. View abstract.
Im GJ, Chang JW, Choi J, Chae SW, Ko EJ, Jung HH. Protective effect of Korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells. Phytother Res 2010;24(4):614-21. View abstract.
Ito, T. Y., Polan, M. L., Whipple, B., and Trant, A. S. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther 2006;32(5):369-378. View abstract.
Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. View abstract.
Jang HI, Shin HM. Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Am J Chin Med 2010;38(5):949-60. View abstract.
Jang, D. J., Lee, M. S., Shin, B. C., Lee, Y. C., and Ernst, E. Red ginseng for treating erectile dysfunction: a systematic review. Br.J Clin.Pharmacol. 2008;66(4):444-450. View abstract.
Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol 2006;46:1370-8. View abstract.
Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004;57:592-9. View abstract.
Jie YH, Cammisuli S, Baggiolini M. Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Agents Actions 1984;15(3-4):386-91. View abstract.
Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. View abstract.
Jovanovski E, Jenkins A, Dias AG, Peeva V, Sievenpiper J, Arnason JT, Rahelic D, Josse RG, Vuksan V. Effects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individuals. Am J Hypertens 2010;23(5):469-72. View abstract.
Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, Kang HY. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Chin Med 2011;39(3):441-50. View abstract.
Jung JS, Shin JA, Park EM, Lee JE, Kang YS, Min SW, Kim DH, Hyun JW, Shin CY, Kim HS. Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression. J Neurochem 2010;115(6):1668-80. View abstract.
Kabalak AA, Soyal OB, Urfalioglu A, et al. Menometrorrhagia and tachyarrhythmia after using oral and topical ginseng. J Womens Health (Larchmt) 2004;13:830-3. View abstract.
Kakisaka Y, Ohara T, Tozawa H, Sato S, Katayama S, Suzuki T, Hino-Fukuyo N, Kure S. Panax ginseng: a newly identified cause of gynecomastia. Tohoku J Exp Med 2012;228(2):143-5. View abstract.
Kaku T, Miyata T, Uruno T, Sako I, Kinoshita A. Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforschung 1975;25(4):539-47. View abstract.
Kang TH, Park HM, Kim YB, Kim H, Kim N, Do JH, Kang C, Cho Y, Kim SY. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol 2009;123(3):446-51. View abstract.
Kanzaki T, Morisaki N, Shiina R, Saito Y. Role of transforming growth factor-beta pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra. Br J Pharmacol 1998;125(2):255-62. View abstract.
Kase Y, Saitoh K, Ishige A, et al. Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels. Biol Pharm Bull 1998;21:1277-81. View abstract.
Katano M, Yamamoto H, Matsunaga H, Mori M, Takata K, Nakamura M. [Cell growth inhibitory substance isolated from Panax ginseng root: panaxytriol]. Gan To Kagaku Ryoho 1990;17(5):1045-9. View abstract.
Kennedy DO, Scholey AB, Drewery L, Marsh VR, Moore B, Ashton H. Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers. Pharmacol Biochem Behav 2003;75(3):701-9. View abstract.
Keum YS, Park KK, Lee JM, et al. Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett 2000;150:41-8.. View abstract.
Kim do Y, Park MW, Yuan HD, Lee HJ, Kim SH, Chung SH. Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells. J Agric Food Chem 2009;57(22):10573-8. View abstract.
Kim H, Chen X, Gillis CN. Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem Biophys Res Commun 1992;189(2):670-6. View abstract.
Kim H, Oh I, Park KH, Kim NM, Do JH, Cho Y. Stimulatory effect of dietary red ginseng on epidermal hydration and ceramide levels in ultraviolet-irradiated hairless mice. J Med Food 2009;12(4):746-54. View abstract.
Kim HG, Cho JH, Yoo SR, Lee JS, Han JM, Lee NH, Ahn YC, Son CG. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PLoS One 2013;8(4):e61271. View abstract.
Kim HJ, Woo DS, Lee G, Kim JJ. The relaxation effects of ginseng saponin in rabbit corporal smooth muscle: is it a nitric oxide donor? Br J Urol 1998;82(5):744-8. View abstract.
Kim HS, Kim DH, Kim BK, Yoon SK, Kim MH, Lee JY, Kim HO, Park YM. Effects of topically applied Korean red ginseng and its genuine constituents on atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol 2011;11(2):280-5. View abstract.
Kim JY, Germolec DR, Luster MI. Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol 1990;12(2):257-76. View abstract.
Kim KR, Chung TY, Shin H, Son SH, Park KK, Choi JH, Chung WY. Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Biol Pharm Bull 2010;33(4):604-10. View abstract.
Kim SH, Cho SS, Simkhada JR, Lee HJ, Kim SW, Kim TS, Yoo JC. Enhancement of 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced HL-60 leukemia cell differentiation by Panax ginseng. Biosci Biotechnol Biochem 2009;73(5):1048-53. View abstract.
Kim SH, Park KS. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol Res 2003;48:511-3. View abstract.
Kim SY, Seo SK, Choi YM, Jeon YE, Lim KJ, Cho S, Choi YS, Lee BS. Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial. Menopause 2012;19(4):461-6. View abstract.
Kim YH, Kim GH, Shin JH, Kim KS, Lim JS. Effect of korean red ginseng on testicular tissue injury after torsion and detorsion. Korean J Urol 2010;51(11):794-9. View abstract.
Kim YK, Guo Q, Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology 2002;172:149-56. View abstract.
Kim, J. H., Park, C. Y., and Lee, S. J. Effects of sun ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial. J Clin Pharm Ther 2006;31(4):331-334. View abstract.
Kim, J. H., Yoon, I. S., Lee, B. H., Choi, S. H., Lee, J. H., Lee, J. H., Jeong, S. M., Kim, S. C., Park, C. K., Lee, S. M., and Nah, S. Y. Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting. Arch Pharm Res 2005;28(6):680-684. View abstract.
Kim, S. H., Park, K. S., Chang, M. J., and Sung, J. H. Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness 2005;45(2):178-182. View abstract.
Kim, S., Shin, B. C., Lee, M. S., Lee, H., and Ernst, E. Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials. Chin J Integr.Med 2011;17(12):937-944. View abstract.
Kim, T. H., Jeon, S. H., Hahn, E. J., Paek, K. Y., Park, J. K., Youn, N. Y., and Lee, H. L. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl 2009;11(3):356-361. View abstract.
Kimura, Y., Okuda, H., and Arichi, S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988;40(12):838-843. View abstract.
Kulaputana, O., Thanakomsirichot, S., and Anomasiri, W. Ginseng supplementation does not change lactate threshold and physical performances in physically active Thai men. J Med Assoc Thai. 2007;90(6):1172-1179. View abstract.
Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS. Antiplatelet components in Panax ginseng. Planta Med 1990;56(2):164-7. View abstract.
Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33(3):468-72. View abstract.
Kwon, K. R., Kim, H., Kim, J. S., Yoo, H. S., and Cho, C. K. Case series of non-small cell lung cancer treated with mountain Ginseng pharmacopuncture. J Acupunct.Meridian.Stud. 2011;4(1):61-68. View abstract.
Le Gal M, Cathebras P, and Struby K. Pharmaton capsules in the treatment of functional fatigue. A double-blind study versus placebo evaluated by a new methodology. Phytotherapy Research 1996;10(1):49-53.
Lee B, Park J, Kwon S, Park MW, Oh SM, Yeom MJ, Shim I, Lee HJ, Hahm DH. Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus. J Pharm Pharmacol 2010;62(2):263-71. View abstract.
Lee BM, Lee SK, Kim HS. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). Cancer Lett 1998;132:219-27. View abstract.
Lee CS, Lee JH, Oh M, Choi KM, Jeong MR, Park JD, Kwon DY, Ha KC, Park EO, Lee N, Kim SY, Choi EK, Kim MG, Chae SW. Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial. J Korean Med Sci 2012;27(12):1472-8. View abstract.
Lee FC, Ko JH, Park JK, Lee JS. Effects of Panax ginseng on blood alcohol clearance in man. Clin Exp Pharmacol Physiol 1987;14:543-6. View abstract.
Lee J, Lee E, Kim D, Lee J, Yoo J, Koh B. Studies on absorption, distribution and metabolism of ginseng in humans after oral administration. J Ethnopharmacol 2009;122(1):143-8. View abstract.
Lee JH, Cho SH. Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: an atopic dermatitis model. J Ethnopharmacol 2011;133(2):810-7. View abstract.
Lee JK, Kang HW, Kim JH, Lim YJ, Koh MS, Lee JH. Effects of Korean red ginseng as an adjuvant to bile acids in medical dissolution therapy for gallstones: a prospective, randomized, controlled, double-blind pilot trial. Food Funct 2013;4(1):116-20. View abstract.
Lee KD, Huemer RP. Antitumoral activity of Panax ginseng extracts. Jpn J Pharmacol 1971;21(3):299-302. View abstract.
Lee LS, Stephenson KK, Fahey JW, Parsons TL, Lietman PS, Andrade AS, Lei X, Yun H, Soon GH, Shen P, Danishefsky S, Flexner C. Induction of chemoprotective phase 2 enzymes by ginseng and its components. Planta Med 2009;75(10):1129-33. View abstract.
Lee MH, Kwak JH, Jeon G, Lee JW, Seo JH, Lee HS, Lee JH. Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study. Food Funct 2014;5(3):528-34. View abstract.
Lee S, Jung J, and Cho D. Ginseng application on the skin enhances synthesis of extracellular matrix proteins:217. The Journal of Investigative Dermatology 1996;106(4):842.
Lee SD, Park SK, Lee ES, Kim HM, Lee CW, Lee K, Lee KH, Kang MR, Lee KS, Lee J, Hwang WI, Kim DC. A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice. J Med Food 2010;13(1):1-5. View abstract.
Lee SH, Ahn YM, Ahn SY, et al. Interaction between warfarin and Panax ginseng in ischemic stroke patients. J Altern Complement Med 2008;14:715-721. View abstract.
Lee SJ, Moon TW, Lee J. Increases of 2-furanmethanol and maltol in Korean red ginseng during explosive puffing process. J Food Sci 2010;75(2):C147-51. View abstract.
Lee TF, Shiao YJ, Chen CF, Wang LC. Effect of ginseng saponins on beta-amyloid-suppressed acetylcholine release from rat hippocampal slices. Planta Med 2001;67(7):634-7. View abstract.
Lee WH, Choi JS, Kim HY, Park JH, Park BD, Cho SJ, Lee SK, Surh YJ. Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation. Cancer Lett 2010;294(1):74-81. View abstract.
Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 2003;84(4):463-8. View abstract.
Lee YJ, Jin YR, Lim WC, et al. Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res 2003;26:58-63.. View abstract.
Lee, D. C., Lee, M. O., Kim, C. Y., and Clifford, D. H. Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular function in dogs. Can J Comp Med 1981;45(2):182-187. View abstract.
Lee, J. H., Kwon, K. R., Cho, C. K., Han, S. S., and Yoo, H. S. Advanced cancer cases treated with cultivated wild ginseng phamacopuncture. J Acupunct.Meridian.Stud. 2010;3(2):119-124. View abstract.
Lee, J. S., Kwon, K. A., Jung, H. S., Kim, J. H., and Hahm, K. B. Korea red ginseng on Helicobacter pylori-induced halitosis: newer therapeutic strategy and a plausible mechanism. Digestion 2009;80(3):192-199. View abstract.
Lee, S. T., Chu, K., Sim, J. Y., Heo, J. H., and Kim, M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis.Assoc.Disord. 2008;22(3):222-226. View abstract.
Lee, Y. H., Lee, B. K., Choi, Y. J., Yoon, I. K., Chang, B. C., and Gwak, H. S. Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement. Int J Cardiol. 11-19-2010;145(2):275-276. View abstract.
Lewis R, Wake G, Court G, et al. Non-ginsenoside nicotinic activity in ginseng species. Phytother Res 1999;13;59-64. View abstract.
Li X, Guo R, Li L. [Pharmacological variations of Panax ginseng C.A. Meyer during processing]. Zhongguo Zhong Yao Za Zhi 1991;16(1):3-7, 62. View abstract.
Liang W, Ge S, Yang L, Yang M, Ye Z, Yan M, Du J, Luo Z. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res 2010;1357:19-25. View abstract.
Lim YJ, Na HS, Yun YS, Choi IS, Oh JS, Rhee JH, Cho BH, Lee HC. Suppressive effects of ginsan on the development of allergic reaction in murine asthmatic model. Int Arch Allergy Immunol 2009;150(1):32-42. View abstract.
Liu GY, Li XW, Wang NB, Zhou HY, Wei W, Gui MY, Yang B, Jin YR. Three new dammarane-type triterpene saponins from the leaves of Panax ginseng C.A. Meyer. J Asian Nat Prod Res 2010;12(10):865-73. View abstract.
Liu J, Wang S, Liu H, Yang L, Nan G. Stimulatory effect of saponin from Panax ginseng on immune function of lymphocytes in the elderly. Mech Ageing Dev 1995;83(1):43-53. View abstract.
Liu YM, Yang L, Zeng X, Deng YH, Feng Y, Liang WX. [Pharmacokinetics of ginsenosides Rg1 and Re in Shenmai injection]. Yao Xue Xue Bao 2005;40(4):365-8. View abstract.
Liu Z, Wang LJ, Li X, Hu JN, Chen Y, Ruan CC, Sun GZ. Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Phytother Res 2009;23(10):1426-30. View abstract.
Liu, P., Xu, Y., Yin, H., Wang, J., Chen, K., and Li, Y. Developmental toxicity research of ginsenoside Rb1 using a whole mouse embryo culture model. Birth Defects Res B Dev Reprod Toxicol 2005;74(2):207-209. View abstract.
Liu, P., Yin, H., Xu, Y., Zhang, Z., Chen, K., and Li, Y. Effects of ginsenoside Rg1 on postimplantation rat and mouse embryos cultured in vitro. Toxicol In Vitro 2006;20(2):234-238. View abstract.
Lu X, Cheng BB, Ling CQ. [Effects of different assemblages with components of Shengmai Powder on glucocorticoid receptor in liver of thermal injured rat]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010;30(6):622-4. View abstract.
Malati CY, Robertson SM, Hunt JD, Chairez C, Alfaro RM, Kovacs JA, Penzak SR. Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. J Clin Pharmacol 2012;52(6):932-9. View abstract.
Martínez-Mir I, Rubio E, Morales-Olivas FJ, Palop-Larrea V. Transient ischemic attack secondary to hypertensive crisis related to Panax ginseng. Ann Pharmacother 2004;38(11):1970. View abstract.
Mateo-Carrasco, H., Galvez-Contreras, M. C., Fernandez-Gines, F. D., and Nguyen, T. V. Elevated liver enzymes resulting from an interaction between Raltegravir and Panax ginseng: a case report and brief review. Drug Metabol.Drug Interact. 2012;27(3):171-175. View abstract.
McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004;291:216-21. View abstract.
Min, K. T., Koo, B. N., Kang, J. W., Bai, S. J., Ko, S. R., and Cho, Z. H. Effect of ginseng saponins on the recombinant serotonin type 3A receptor expressed in xenopus oocytes: implication of possible application as an antiemetic. J Altern Complement Med 2003;9(4):505-510. View abstract.
Ming YL, Chen ZY, Chen LH, Tong QX, Zheng ZZ, Zheng GH, Qi XH. [Inhibitory effect of ginseng saponin IH901 on proliferation and metastasis of ECV304 cell line and its molecular mechanism]. Yao Xue Xue Bao 2009;44(9):967-72. View abstract.
Mizuno M, Yamada J, Terai H, Kozukue N, Lee YS, Tsuchida H. Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem Biophys Res Commun 1994;200(3):1672-8. View abstract.
Moon J, Yu SJ, Kim HS, Sohn J. Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng. Biochem Pharmacol 2000;59:1109-16.. View abstract.
Nabata H, Saito H, Takagi K. Pharmacological studies of neutral saponins (GNS) of Panax Ginseng root. Jpn J Pharmacol 1973;23(1):29-41. View abstract.
Nakaya TA, Kita M, Kuriyama H, Iwakura Y, Imanishi J. Panax ginseng induces production of proinflammatory cytokines via toll-like receptor. J Interferon Cytokine Res 2004;24(2):93-100. View abstract.
Neri, M., Andermarcher, E., Pradelli, J. M., and Salvioli, G. Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment. Arch Gerontol.Geriatr. 1995;21(3):241-252. View abstract.
Ng TB, Wang H. Panaxagin, a new protein from Chinese ginseng possesses anti-fungal, anti-viral, translation-inhibiting and ribonuclease activities. Life Sci 2001;68:739-49. View abstract.
Nguyen HT, Song GY, Kim JA, Hyun JH, Kang HK, Kim YH. Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells. Bioorg Med Chem Lett 2010;20(1):309-14. View abstract.
Ni, H. X., Yu, N. J., and Yang, X. H. The study of ginsenoside on PPARgamma expression of mononuclear macrophage in type 2 diabetes. Mol.Biol Rep. 2010;37(6):2975-2979. View abstract.
Niederhofer, H. Panax ginseng may improve some symptoms of attention-deficit hyperactivity disorder. Journal of Dietary Supplements 2009;6(1):22-27.
Nitta H, Matsumoto K, Shimizu M, Ni XH, Watanabe H. Panax ginseng extract improves the scopolamine-induced disruption of 8-arm radial maze performance in rats. Biol Pharm Bull 1995;18(10):1439-42. View abstract.
Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, Ha KC, Na WT, Cha YS, Park BH, Park TS, Chae SW. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med 2014;14:237. View abstract.
Oh, K. J., Chae, M. J., Lee, H. S., Hong, H. D., and Park, K. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med 2010;7(4 Pt 1):1469-1477. View abstract.
Oyagi A, Ogawa K, Kakino M, Hara H. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. BMC Complement Altern Med 2010;10:45. View abstract.
Palmer BV, Montgomery AC, Monteiro JC, et al. Gin Seng and mastalgia [letter]. BMJ 1978;1:1284. View abstract.
Palop-Larrea V, Gonzalvez-Perales JL, Catalan-Oliver C, et al. Metrorrhagia and ginseng. Ann Pharmacother 2000;34:1347-8. View abstract.
Pan SJ, Ding Z, Ivy JL. Ginseng's effects on glucose tolerance and mRNA profiles in a animal model of Type II diabetes. Altern Ther 2001;7:S26.
Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004;133(2):113-20. View abstract.
Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26(11):1581-4. View abstract.
Park HJ, Lee JH, Song YB, Park KH. Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull 1996;19:1434-9. View abstract.
Park HJ, Rhee MH, Park KM, Nam KY, Park KH. Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation. J Ethnopharmacol 1995;49(3):157-62. View abstract.
Park JS, Hwang SY, Lee WS, Yu KW, Paek KY, Hwang BY, Han K. The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder. Arch Pharm Res 2006;29(9):800-7. View abstract.
Park JS, Park EM, Kim DH, Jung K, Jung JS, Lee EJ, Hyun JW, Kang JL, Kim HS. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009;209(1-2):40-9. View abstract.
Park SE, Park C, Kim SH, Hossain MA, Kim MY, Chung HY, Son WS, Kim GY, Choi YH, Kim ND. Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol 2009;121(2):304-12. View abstract.
Park SH, Jang JH, Chen CY, Na HK, Surh YJ. A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase. Toxicology 2010;278(1):131-9. View abstract.
Persson IA, Dong L, Persson K. Effect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production. J Ethnopharmacol 2006;105(3):321-5. View abstract.
Ping FW, Keong CC, Bandyopadhyay A. Effects of acute supplementation of Panax ginseng on endurance running in a hot & humid environment. Indian J Med Res 2011;133:96-102. View abstract.
Punnonen R, Lukola A. Oestrogen-like effect of ginseng. Br Med J 1980;281:1110.. View abstract.
Raghavendran HR, Rekha S, Shin JW, Kim HG, Wang JH, Park HJ, Choi MK, Cho JH, Son CG. Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model. Food Chem Toxicol 2011;49(1):215-21. View abstract.
Reay, J. L., Kennedy, D. O., and Scholey, A. B. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol. 2006;20(6):771-781. View abstract.
Reay, J. L., Kennedy, D. O., and Scholey, A. B. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005;19(4):357-365. View abstract.
Reay, J. L., Kennedy, D. O., and Scholey, A. B. The glycaemic effects of single doses of Panax ginseng in young healthy volunteers. Br J Nutr 2006;96(4):639-642. View abstract.
Reay, J. L., Scholey, A. B., and Kennedy, D. O. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010;25(6):462-471. View abstract.
Reay, J. L., Scholey, A. B., Milne, A., Fenwick, J., and Kennedy, D. O. Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers. Br J Nutr 2009;101(11):1673-1678. View abstract.
Reeds DN, Patterson BW, Okunade A, et al. Ginseng and ginsenoside re do not improve beta-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care 2011;34:1071-6. View abstract.
Rhee MY, Cho B, Kim KI, Kim J, Kim MK, Lee EK, Kim HJ, Kim CH. Blood pressure lowering effect of Korea ginseng derived ginseol K-g1. Am J Chin Med 2014;42(3):605-18. View abstract.
Rhee MY, Kim YS, Bae JH, Nah DY, Kim YK, Lee MM, Kim HY. Effect of Korean red ginseng on arterial stiffness in subjects with hypertension. J Altern Complement Med 2011;17(1):45-9. View abstract.
Ruan CC, Liu Z, Li X, Liu X, Wang LJ, Pan HY, Zheng YN, Sun GZ, Zhang YS, Zhang LX. Isolation and characterization of a new ginsenoside from the fresh root of Panax Ginseng. Molecules 2010;15(4):2319-25. View abstract.
Rudakewich M, Ba F, Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med 2001;67(6):533-7. View abstract.
Ryu S, Chien Y. Ginseng-associated cerebral arteritis. Neurology 1995;45:829-30. View abstract.
Sakakibara K, Shibata Y, Higashi T, Sanada S, Shoji J. Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides. Chem Pharm Bull (Tokyo) 1975;23(5):1009-16. View abstract.
Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M, Re M. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38(4):249-54. View abstract.
Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold. Drugs Exp Clin Res 1996;22:65-72. View abstract.
Scaglione F, Cogo R, and Cocuzza C. Immunomodulatory effects of Panax ginseng C.A.Meyer (G115) on alveolar macrophages from patients suffering with chronic bronchitis. Int J Immunother 1994;10(1):21-24.
Scaglione F, Weiser K, Alessandria M. Effects of the standardized ginseng extract G115 (Reg.) in patients with chronic bronchitis: A nonblinded, randomized, comparative pilot study. Clin Drug Invest 2001;21:41-5.
Scholey AB, Kennedy DO. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand. Hum Psychopharmacol 2002;17:35-44.. View abstract.
See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 1997;35:229-35. View abstract.
Sen A. Orobuccolingual dyskinesia after long-term use of black cohosh and ginseng. J Neuropsychiatry Clin Neurosci 2013 Fall;25(4):E50. View abstract.
Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. View abstract.
Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY. Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol 2010;242(3):318-25. View abstract.
Shin HR, Kim JY, Yun TK, et al. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 2000;11:565-76. View abstract.
Shin, S. K., Kwon, J. H., Jeong, Y. J., Jeon, S. M., Choi, J. Y., and Choi, M. S. Supplementation of cheonggukjang and red ginseng cheonggukjang can improve plasma lipid profile and fasting blood glucose concentration in subjects with impaired fasting glucose. J Med Food 2011;14(1-2):108-113. View abstract.
Shukla R, Kumar M. Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries. Food Chem Toxicol 2009;47(4):769-73. View abstract.
Siddique MS, Eddeb F, Mantle D, Mendelow AD. Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro. Acta Neurochir Suppl 2000;76:87-90. View abstract.
Siegel RK. Ginseng Abuse Syndrome. JAMA 1979;241:1614-5.
Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. View abstract.
Sievenpiper, J. L., Sung, M. K., Di Buono, M., Seung-Lee, K., Nam, K. Y., Arnason, J. T., Leiter, L. A., and Vuksan, V. Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies. J Am Coll.Nutr 2006;25(2):100-107. View abstract.
Smith M, Lin KM, and Zheng YP. PIII-89 an open trial of nifedipine-herb interactions: Nifedipine with St. John's wort, ginseng or ginkgo biloba. Clin Pharm Ther 2001;69:P86.
Smolina TP, Solov'eva TF, Besednova NN. [Immunotropic activity of panaxans--bioglycans isolated from ginseng]. Antibiot Khimioter 2001;46(7):19-22. View abstract.
Song Z, Johansen HK, Faber V, et al. Ginseng treatment reduces bacterial load and lung pathology in chronic Pseudomonas aeruginosa pneumonia in rats. Antimicrob Agents Chemother 1997;41:961-4. View abstract.
Song Z, Kharazmi A, Wu H, et al. Effects of Ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia. Clin Diagn Lab Immunol 1998;5:882-7. View abstract.
Sorensen H, Sonne J. A double-masked study of the effects of ginseng on cognitive functions. Curr Ther Res 1996;57:959-68.
Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995;18:1373-5. View abstract.
Su W, Sun AJ, Xu DL, Zhang HQ, Yang L, Yuan LY, Jia JG, Zou YZ, Wu YL, Wang KQ, Ge JB. Inhibiting effects of total saponins of panax ginseng on immune maturation of dendritic cells induced by oxidized-low density lipoprotein. Cell Immunol 2010;263(1):99-104. View abstract.
Sugimoto S, Nakamura S, Matsuda H, Kitagawa N, Yoshikawa M. Chemical constituents from seeds of Panax ginseng: structure of new dammarane-type triterpene ketone, panaxadione, and hplc comparisons of seeds and flesh. Chem Pharm Bull (Tokyo) 2009;57(3):283-7. View abstract.
Sun XB, Matsumoto T, Yamada H. Anti-ulcer activity and mode of action of the polysaccharide fraction from the leaves of Panax ginseng. Planta Med 1992;58(5):432-5. View abstract.
Sung, H., Jung, Y. S., and Cho, Y. K. Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients. Clin Vaccine Immunol. 2009;16(8):1127-1131. View abstract.
Suzuki H, Rhim JH. Effect of samgyetang feeding on plasma lipids, glucose, glycosylated hemoglobin, and stress-induced gastric ulcers in mice. Nutr Res 2000;20:575-84.
Takagi K, Saito H, Nabata H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 1972;22(2):245-9. View abstract.
Tamaoki J, Nakata J, Kawatani K, et al. Ginsenoside-induced relaxation of human bronchial smooth muscle via release of nitric oxide. Br J Pharmacol 2000;130:1859-64. View abstract.
Teng CM, Kuo SC, Ko FN, Lee JC, Lee LG, Chen SC, Huang TF. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 1989;990(3):315-20. View abstract.
Tode T, Kikuchi Y, Hirata J, et al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet 1999;67:169-74. View abstract.
Toh HT. Improved isolated heart contractility and mitochondrial oxidation after chronic treatment with Panax ginseng in rats. Am J Chin Med 1994;22(3-4):275-84. View abstract.
Tong LS, Chao CY. Effects of ginsenoside Rg1 of Panax ginseng on mitosis in human blood lymphocytes in vitro. Am J Chin Med 1980 Autumn;8(3):254-67. View abstract.
Tu LH, Ma J, Liu HP, Wang RR, Luo J. The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells. Cell Mol Neurobiol 2009;29(8):1257-64. View abstract.
Tung NH, Song GY, Minh CV, Kiem PV, Jin LG, Boo HJ, Kang HK, Kim YH. Steamed ginseng-leaf components enhance cytotoxic effects on human leukemia HL-60 cells. Chem Pharm Bull (Tokyo) 2010;58(8):1111-5. View abstract.
Tung NH, Song GY, Nhiem NX, Ding Y, Tai BH, Jin LG, Lim CM, Hyun JW, Park CJ, Kang HK, Kim YH. Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity. J Agric Food Chem 2010;58(2):868-74. View abstract.
Vilstrup H, Gluud C, Hardt F, et al. Branched chain enriched amino acid versus glucose treatment of hepatic encephalopathy. A double-blind study of 65 patients with cirrhosis. J Hepatol 1990;10:291-6. View abstract.
Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systemic review of randomized clinical trials. Eur J Clin Pharmacol 1999;55:567-75. View abstract.
Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. View abstract.
Vuksan, V., Sung, M. K., Sievenpiper, J. L., Stavro, P. M., Jenkins, A. L., Di, Buono M., Lee, K. S., Leiter, L. A., Nam, K. Y., Arnason, J. T., Choi, M., and Naeem, A. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc.Dis 2008;18(1):46-56. View abstract.
Wakabayashi C, Hasegawa H, Murata J, Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1997;9(8):411-7. View abstract.
Wang J, Flaisher-Grinberg S, Li S, Liu H, Sun L, Zhou Y, Einat H. Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice. J Ethnopharmacol 2010;132(1):65-9. View abstract.
Wang Q, Sun LH, Jia W, Liu XM, Dang HX, Mai WL, Wang N, Steinmetz A, Wang YQ, Xu CJ. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytother Res 2010;24(12):1748-54. View abstract.
Wang T, Yu XF, Qu SC, Xu HL, Sui DY. Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation. Basic Clin Pharmacol Toxicol 2010;107(2):685-9. View abstract.
Wang X, Chu S, Qian T, Chen J, Zhang J. Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine monophosphate pathway. J Sex Med 2010;7(2 Pt 1):743-50. View abstract.
Wang X, Zheng YL, Li K, Lin N, Fan QX. [The effects of ginsenosides Rg3 on the expressions of VEGF and KDR in human lung squamous cancer cells]. Zhong Yao Cai 2009;32(11):1708-10. View abstract.
Wang Y, Liu J, Zhang Z, Bi P, Qi Z, Zhang C. Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease. Neurosci Lett 2011;487(1):70-2. View abstract.
Wesnes KA, Ward T, McGinty A, Petrini O. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl) 2000;152:353-61.. View abstract.
Wiklund I, Karlberg J, and Lund B. A double bind comparison of the effect on quality of life of a combination of vital substances including standarized ginseng G115 and placebo. Curr Ther Res 1994;55(1):32-42.
Wiklund IK, Mattsson LA, Lindgren R, et al. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharmacol Res 1999;19:89-99.. View abstract.
Wiwanikit V, Taungjarwinai W. A case report of suspected ginseng allergy. Medscape General Medicine 6 (3), 2004. Available at: www.medscape.com/viewarticle/482833 (Accessed 17 September 2004).
Wong VK, Cheung SS, Li T, Jiang ZH, Wang JR, Dong H, Yi XQ, Zhou H, Liu L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling. J Cell Biochem 2010;111(4):899-910. View abstract.
Wu J, Jeong HK, Bulin SE, Kwon SW, Park JH, Bezprozvanny I. Ginsenosides protect striatal neurons in a cellular model of Huntington's disease. J Neurosci Res 2009;87(8):1904-12. View abstract.
Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol 1998;60(1):71-8. View abstract.
Xu C, Teng J, Chen W, Ge Q, Yang Z, Yu C, Yang Z, Jia W. 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Prog Neuropsychopharmacol Biol Psychiatry 2010;34(8):1402-11. View abstract.
Xu QF, Fang XL, Chen DF. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 2003;84:187-92. View abstract.
Xu W, Yue A, Yang X. [GC-MS analysis of essential oil of honeyed red ginseng]. Zhongguo Zhong Yao Za Zhi 2009;34(5):591-5. View abstract.
Yakoot M, Salem A, Helmy S. Effect of Memo, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment. Clin Interv Aging 2013;8:975-81. View abstract.
Yamamoto M, Uemura T, Nakama S, Uemiya M, Kumagai A. Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man. Am J Chin Med 1983;11(1-4):96-101. View abstract.
Yang WM, Park SY, Kim HM, Park EH, Park SK, Chang MS. Effects of Panax ginseng on glial cell-derived neurotrophic factor (GDNF) expression and spermatogenesis in rats. Phytother Res 2011;25(2):308-11. View abstract.
Ye R, Li N, Han J, Kong X, Cao R, Rao Z, Zhao G. Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neurosci Res 2009;64(3):306-10. View abstract.
Yi RL, Li W, Hao XZ. [Inductive differentiation effect of ginsenosides on human acute non-lymphocytic leukemic cells in 58 patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):722-4, 708. View abstract.
Yi XQ, Li T, Wang JR, Wong VK, Luo P, Wong IY, Jiang ZH, Liu L, Zhou H. Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling. Phytomedicine 2010;17(13):1006-15. View abstract.
Yoo JH, Kwon HC, Kim YJ, Park JH, Yang HO. KG-135, enriched with selected ginsenosides, inhibits the proliferation of human prostate cancer cells in culture and inhibits xenograft growth in athymic mice. Cancer Lett 2010;289(1):99-110. View abstract.
Yun TK, Choi SY. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 1998;27:359-64. View abstract.
Yun TK, Lee YS, Lee YH, Kim SI, Yun HY. Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci 2001;16 Suppl:S6-18. View abstract.
Yun YP, Do JH, Ko SR, et al. Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation. J Ethnopharmacol 2001;77:259-64. View abstract.
Yun YS, Lee YS, Jo SK, Jung IS. Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator. Planta Med 1993;59(6):521-4. View abstract.
Yun, T. K., Zheng, S., Choi, S. Y., Cai, S. R., Lee, Y. S., Liu, X. Y., Cho, K. J., and Park, K. Y. Non-organ-specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers. J Med Food 2010;13(3):489-494. View abstract.
Zhang, R., Jie, J., Zhou, Y., Cao, Z., and Li, W. Long-term effects of Panax ginseng on disposition of fexofenadine in rats in vivo. Am J Chin Med 2009;37(4):657-667. View abstract.
Zhao H, Li Q, Pei X, Zhang Z, Yang R, Wang J, Li Y. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behav Brain Res 2009;201(2):311-7. View abstract.
Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the pharmacodynamics of warfarin in rats. J Pharm Pharmacol 1999;51:175-80. View abstract.