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What other names is Grape known by?

Activin, Black Grape Raisins, Calzin, Draksha, Enocianina, European Wine Grape, Extrait de Feuille de Raisin, Extrait de Feuille de Vigne Rouge, Extrait de Peau de Raisin, Extrait de Pepins de Raisin, Feuille de Raisin, Feuille de Vigne Rouge, Feuille de Vigne Rouge AS 195, Flame Grape, Flame Raisins, Flame Seedless, Folia Vitis Viniferae, Grape Fruit, Grape Fruit Skin, Grape Juice, Grape Leaf, Grape Leaf Extract, Grape Seed, Grape Seed Extract, Grape Seed Oil, Grape Skin, Grape Skin Extract, Grapes, Grapeseed, Huile de Pépins de Raisin, Kali Draksha, Leucoanthocyanin, Muscat, Muskat, Oligomères Procyanidoliques, Oligomeric Proanthocyanidins, Oligomeric Procyanidins, OPC, OPCs, PCO, PCOs, Peau de Raisin, Pépin de Raisin, Petite Sirah, Proanthocyanidines Oligomériques, Proanthodyn, Proanthodyne, Procyanidines Oligomériques, Procyanidolic Oligomers, Purple Grape, Raisin, Raisin Blanc, Raisin de Table, Raisin de Vigne, Raisins, Raisins Noirs, Red Globe, Red Grape, Red Malaga, Red Vine Leaf AS 195, Red Vine Leaf Extract, Sultanas, Table Grapes, Thompson Seedless, Uva, Vitis vinifera, White Grape, Wine Grape, Wine Grapes.

What is Grape?

Grapes are the fruit of a vine (Vitis vinifera). The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines.

Grape is used for preventing diseases of the heart and blood vessels, varicose veins, hemorrhoids, "hardening of the arteries" (atherosclerosis), high blood pressure, swelling after injury or surgery, heart attack, and stroke.

Some people also use grape as a mild laxative for constipation. You have probably heard of grape "fasts" as part of "detoxification."

Grape seed is used for diabetes complications such as nerve and eye problems, improving wound healing, preventing tooth decay, preventing cancer, an eye disease called age-related macular degeneration (AMD), poor night vision, liver disorders, and hay fever.

Dried grapes, raisins, or sultanas (white raisins) are used for cough.

Grape leaf is used for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine bleeding, and canker sores.

Grape leaf is used as a food, particularly in Greek cooking.

Possibly Effective for...

  • Poor circulation that can cause the legs to swell (chronic venous insufficiency). Taking grape seed extract by mouth seems to reduce symptoms of chronic venous insufficiency such as tired or heavy legs, tension, and tingling and pain. Research suggests that taking a specific grape leaf extract (AS 195, Antistax, Boehringer Ingelheim) by mouth decreases leg swelling after 6 weeks.
  • Eye stress. Taking grape seed extract by mouth might help decrease stress on the eyes from glare.

Possibly Ineffective for...

  • Hay fever. Taking grape seed extract for 8 weeks before ragweed pollen season does not seem to decrease seasonal allergy symptoms or the need to use allergy medications.
  • Tissue hardness and pain caused by radiation. Research shows that taking proanthocyanidin, a chemical found in grape seed extract, three times daily for 6 months does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer.
  • Nausea and vomiting caused by chemotherapy. Evidence shows that taking 4 ounces of chilled Concord grape juice 30 minutes before meals for a week following each cycle of chemotherapy does not seem to reduce nausea or vomiting caused by chemotherapy.
  • Weight loss. Evidence suggests that drinking Concord grape juice for 12 weeks does not reduce weight in overweight people.

Insufficient Evidence to Rate Effectiveness for...

  • Athletic performance. Early research shows that taking 400 mg of grape extract daily for one month might increase an athlete's overall power when jumping, but not the initial power or maintenance of power.
  • Heart disease. There is some early evidence that drinking grape juice or red wine might help to prevent heart disease by reducing cholesterol levels, reducing inflammation, and preventing clot formations.
  • Eye damage caused by diabetes (diabetic retinopathy). Early evidence suggests that taking a specific grape seed extract product (Endotelon) can slow the progression of eye damage caused by diabetes.
  • High cholesterol. Some research shows that taking 100 mg of grape seed extract twice daily for up to 2 months does not lower cholesterol levels in people with high cholesterol. However, other research shows that grape seed extract might lower cholesterol when taken in combination with other ingredients, including chromium or policosanol, tomato extract, and evening primrose oil.
  • High blood pressure. Research suggests that grape seed extract does not reduce blood pressure in healthy people or people with high blood pressure. However, in men with metabolic syndrome, a cluster of conditions that increase the risk for heart disease, taking freeze-dried, dehydrated whole grapes for 20 days seems to lower blood pressure. Additionally, some studies suggest that drinking grape juice can lower blood pressure in people with high blood pressure; however, other research shows that grape juice does not have this effect.
  • Dark skin patches on the face (melasma). Early research suggests that taking grape seed extract by mouth for 6-11 months reduces dark skin discolorations in Japanese women.
  • Age-related mental decline. Early research shows that drinking Concord grape juice daily for 12 weeks can improve verbal learning, but does not improve memory, in older people with age-related mental decline.
  • Metabolic syndrome. Early research suggests that whole grapes might improve some of the risk factors associated with metabolic syndrome, a cluster of conditions that increase the risk for heart disease, in men. Taking freeze-dried, dehydrated whole grapes for 30 days lowers blood pressure and increases blood flow. However, it is not known if these changes decrease the risk for diabetes or other aspects of metabolic syndrome. Also, other research shows that taking a specific product containing grape seed extract (Meganatural BP) for 4 weeks does not reduce blood pressure in people with metabolic syndrome.
  • Poor night vision. Early research suggests grape seed extract containing chemicals called proanthocyanidins might improve night vision.
  • Nonalcoholic fatty liver disease. Research shows that taking grape seed extract twice daily for 3 months improves some but not all markers of liver damage compared to vitamin C supplementation in people with nonalcoholic fatty liver disease.
  • Premenstrual syndrome (PMS). Early research suggests that taking a specific grape seed extract product (Endetelon) might reduce PMS symptoms, including pain and swelling.
  • Treating varicose veins.
  • Hemorrhoids.
  • Constipation.
  • Cough.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Chronic fatigue syndrome (CFS).
  • Diarrhea.
  • Heavy menstrual periods.
  • Age-related macular degeneration (AMD).
  • Canker sores.
  • Liver damage.
  • Other conditions.
More evidence is needed to rate the effectiveness of grape for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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