- What other names is Green Tea known by?
- What is Green Tea?
- Is Green Tea effective?
- How does Green Tea work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Green Tea.
Benifuuki, Camellia sinensis, Camellia thea, Camellia theifera, Constituant Polyphénolique de Thé Vert, CPTV, EGCG, Epigallo Catechin Gallate, Épigallo-Catéchine Gallate, Epigallocatechin Gallate, Extrait de Camellia Sinensis, Extrait de Thé, Extrait de Thé Vert, Extrait de Thea Sinensis, Green Sencha Tea, Green Tea Extract, Green Tea Polyphenolic Fraction, GTP, GTPF, Japanese Sencha Green Tea, Japanese Tea, Kunecatechins, Poly E, Polyphenon E, PTV, Té Verde, Tea, Tea Extract, Tea Green, Thé, Thé de Camillia, Thé Japonais, Thé Vert, Thé Vert de Yame, Thé Vert Sensha, Thea bohea, Thea sinensis, Thea viridis, Yame Green Tea, Yabukita, Yame Tea.
Green tea is made from the Camellia sinensis plant. The dried leaves and leaf buds of Camellia sinensis are used to produce various types of teas. Green tea is prepared by steaming and pan-frying these leaves and then drying them. Other teas such as black tea and oolong tea involve processes in which the leaves are fermented (black tea) or partially fermented (oolong tea).
Green tea is taken by mouth to improve mental alertness and thinking.
It is also taken by mouth for depression, non-alcoholic fatty liver disease (NAFLD), inflammatory bowel disease (ulcerative colitis or Crohn's disease), weight loss and to treat stomach disorders, vomiting, diarrhea, headaches, and bone loss (osteoporosis).
Some people take green tea by mouth to prevent various cancers, including breast cancer, prostate cancer, colon cancer, gastric cancer, lung cancer, liver cancer, solid tumor cancers, leukemia, and skin cancer related to exposure to sunlight. Some women use green tea to fight human papilloma virus (HPV), which can cause genital warts, the growth of abnormal cells in the cervix (cervical dysplasia), and cervical cancer.
Green tea is also taken by mouth for Parkinson's disease, diseases of the heart and blood vessels, diabetes, low blood pressure, chronic fatigue syndrome (CFS), dental cavities (caries), kidney stones, and skin damage.
Instead of drinking green tea, some people apply green tea bags to their skin to soothe sunburn and prevent skin cancer due to sun exposure. Green tea bags are also used to decrease puffiness under the eyes, as a compress for tired eyes or headache, and to stop gums from bleeding after a tooth is pulled. A green tea footbath is used for athlete's foot.
Green tea is used in an ointment for genital warts.
In food, people drink green tea as a beverage
There is some scientific evidence that drinking green tea can improve thinking skills, and might help lower cholesterol and other fats called triglycerides. Green tea consumption might also prevent or delay Parkinson's disease and possibly help to prevent cancer of the bladder, esophagus, and pancreas. But green tea does not seem to help prevent stomach cancer.
Likely Effective for...
- Genital warts. A specific green tea extract ointment (Veregen, Bradley Pharmaceuticals; Polyphenon E ointment 15%, MediGene AG) is FDA-approved for treating genital warts. Applying the ointment for 10-16 weeks seems to clear these types of warts in 24% to 60% of patients.
- High cholesterol. People to consume higher amounts of green tea seem to have lower levels of cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and triglycerides, as well as higher levels of high-density lipoprotein (HDL or "good") cholesterol. Consuming green tea or taking green tea extract containing 150 to 2500 mg of green tea catechins, an antioxidant found in green tea, daily for up to 24 weeks reduces total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol in people with high levels of blood fats or cholesterol.
Possibly Effective for...
- Abnormal development of cells of the cervix (cervical dysplasia). Taking green tea by mouth or applying it to the skin seems to reduce cervical dysplasia caused by human papilloma virus (HPV) infection.
- Clogged arteries (coronary artery disease). Population studies suggest that drinking green tea is linked to a reduced risk of clogged arteries. The link seems to be stronger in men than women.
- Endometrial cancer. Population studies suggest that drinking green tea is linked to a reduced risk of developing endometrial cancer.
- High blood pressure. There is some conflicting evidence about the effects of tea on high blood pressure. Population research in Chinese people shows that drinking 120-599 mL of green tea or oolong tea daily is linked to a lower risk of developing high blood pressure. Drinking more than 600 mL daily is linked to an even lower risk. Also, early clinical research suggests that taking green tea extract daily for 3 months or drinking green tea three times per day for 4 weeks reduces blood pressure in people with high blood pressure. Analysis of clinical research shows that green tea can reduce systolic blood pressure (the top number) by up to 3.2 mmHg and diastolic blood pressure (the bottom number) by up to 3.4 mmHg in people with or without high blood pressure. But several smaller studies show that green and black tea have no effect on blood pressure.
- Low blood pressure. Drinking green tea might help increase blood pressure in elderly people who have low blood pressure after eating.
- Thick, white patches on the gums (oral leukoplakia). Drinking green tea seems to decrease the size of white patches in people with oral leukoplakia.
- Osteoporosis. A population study suggests that drinking green tea for 10 years is linked to increased bone mineral density. Also, early research suggests that taking a green tea compound containing 500 mg of catechins, an antioxidant in green tea, twice daily for 24 weeks improves bone strength in post-menopausal women with low bone density.
- Ovarian cancer. Women who regularly drink tea, including green or black tea, appear to have a lower risk of developing ovarian cancer. But green tea does not seem to prevent ovarian cancer from recurring in people with a history of ovarian cancer.
- Parkinson's disease. Drinking one to four cups of green tea daily seems to provide the most protection against developing Parkinson's disease.
Insufficient Evidence to Rate Effectiveness for...
- Acne. Early research suggests that applying a solution containing a certain chemical found in green tea to the skin for 8 weeks reduces acne.
- Abnormal protein buildup in the organs (Amyloidosis). Early research suggests that drinking green tea (Green Darjeeling, FTGFOP1, Teekampagne Projektwerkstatt GmbH, Berlin, Germany) or taking green tea capsules (Praevent-loges, Dr. Loges + Co. GmbH, Winsen/Luhe, Germany) containing green tea extracts for 12 months protects against an increase in heart mass in people with amyloidosis affecting the heart.
- Athletic performance. There is conflicting evidence about the effects of green tea on athletic performance. Some early research suggests that taking green tea extract as a beverage does not improve breathing or performance in people undergoing endurance training. However, other early research suggests that taking specific pills (Teavigo, Healthy Origins, Pittsburgh, PA) three times daily with meals for a total dose of seven pills, improves some breathing tests during exercise in healthy adults.
- Bladder cancer. Some population evidence suggests that drinking green tea is linked to a lower risk of bladder cancer. However, some conflicting research suggests that green tea might not reduce the risk of developing bladder cancer.
- Breast cancer. Population research suggests that drinking green tea is not linked to a reduced risk of breast cancer in Asian people. However, there is some evidence that it might be linked with a reduced risk of breast cancer development in Asian-Americans. Green tea might have different protective effects in people depending on their genotype. In people with early-stage but not late-stage breast cancer, drinking green tea seems to be linked with a reduced risk of breast cancer recurring.
- Heart disease. Population studies suggest that drinking three or more cups of green tea daily is linked to a decreased risk of death from heart disease or any cause.
- Cervical cancer. Research suggests that taking a specific type of green tea extract (Polyphenon E) daily for 4 months does not affect cervical cancer risk in women with HPV infection.
- Colds and flu. Early research suggests that taking a combination of green tea extract (THEA-FLAN 90S, Ito-en Co, Tokyo, Japan) plus theanine (Suntheanine, Taiyo Kagaku Co, Mie, Japan) daily for 5 months lowers the risk of developing the flu. Other early research suggests that taking a specific combination product containing green tea and other ingredients (ImmuneGuard, Nutraceutical Holdings LLC, Orlando, FL) reduces cold and flu symptoms and the duration of illness. But other early research suggests that gargling with green tea (Kakegawa Tea Merchants Association) at least three times daily for 90 days does not prevent the flu in high school students.
- Colon and rectal cancer. Most evidence suggests that drinking green tea is not linked with a reduced risk of colon or rectal cancer. However, some research suggests that consuming a high amount is linked to a reduce risk, particularly in women. Also taking green tea extract daily for 12 months seems to reduce the redevelopment of colon and rectal tumors (metachronous adenomas) in people who previously underwent surgery to treat colon and rectal tumors.
- Depression. Population research suggests that Japanese adults who drink four or more cups of green tea daily have a 44% to 51% lower risk for depression than those who drink one cup or less.
- Diabetes. Population research suggests that Japanese adults, particularly women, who drink 6 or more cups of green tea daily, have a lower risk of developing diabetes. Also, population research suggests that drinking at least one cup of green tea per week is linked with a lower risk of developing impaired fasting blood sugar in Chinese people. Impaired fasting blood sugar is a risk factor for developing type 2 diabetes. However, some research shows that drinking green tea three times per day does not help control blood sugar in people with prediabetes. Also, taking green tea extract does not seem to help control sugar or insulin levels in people who already have diabetes. Overall, some evidence suggests that drinking green tea might help prevent diabetes from developing. But most research suggests that drinking green tea or taking green tea extract does not help control blood sugar in people who already have diabetes.
- Esophageal cancer. Some population research suggests that drinking green tea is linked to a reduced risk of esophageal cancer. But there is some conflicting research. Some research suggests that drinking green tea is linked to a reduced risk of esophageal cancer in only women, but not men. Also, some population research suggests that drinking green tea that is very hot is linked to an increased risk of esophageal cancer. Drinking decaffeinated green tea does not seem to benefit people already diagnosed with esophageal cancer.
- Stomach cancer. There is conflicting evidence about the effects of green tea on stomach cancer risk. Some population research suggests that drinking at least 5 cups of green tea daily is not linked with a reduced risk of stomach cancer. But other population research suggests that drinking at least 10 cups of green tea daily is linked with a reduced risk of stomach cancer.
- Fertility problems. Early research suggests that taking a specific product containing a mixture of Vitex agnus-castus extract, green tea extract, and L-arginine, as well as some vitamins and minerals (FertilityBlend, The Daily Wellness Company, Mountain View, CA) increases pregnancy rates in women who have trouble conceiving.
- Allergy to Japanese cedar (pollinosis). Early research suggests that drinking a type of green tea called "Benifuuki" daily for 6-10 weeks before being exposed to Japanese cedar pollen can reduce allergy symptoms, including throat pain, nose blowing, and tears.
- Leukemia. Population research suggests that Taiwanese people who drink higher amounts of green tea have a lower risk of developing leukemia. Other population research shows that Chinese people who drink at least one cup of green tea for at least 20 years have a lower risk of developing leukemia.
- Liver cancer. Population research suggests that drinking green tea is not linked to a reduced risk of liver cancer.
- Lung cancer. There is conflicting evidence about the effects of green tea on lung cancer risk. One population study suggests that drinking at least 5 cups of green tea daily is not linked with a reduced risk of death related to lung cancer. However, men who consume high amounts of phytoestrogens, chemicals found in green tea, have a lower risk of developing lung cancer. Also, some population research suggests that increasing green tea intake by two cups daily or drinking 7-10 cups of green tea daily is linked with a reduced risk of lung cancer.
- Mental alertness. Green tea contains caffeine. Drinking beverages that contain caffeine seems to help people maintain mental alertness throughout the day. Combining caffeine with sugar as an "energy drink" seems to improve mental performance more than caffeine or sugar alone. However, there is conflicting evidence regarding green tea on mental alertness. Some research shows that taking a combination of green tea extract and L-theanine (LGNC-07, LG Household & Health Care, Ltd, Korea) improves memory and attention in people with mild mental problems. However, taking a single dose of a certain chemical in green tea called epigallocathechin-3-gallate (EGCG) does not seem to improve move or mental performance in healthy adults.
- Metabolic syndrome. Early research suggests that taking 1000 mg of green tea extract daily or drinking four cups of green tea daily for 8 weeks does not improve blood pressure, cholesterol levels, or blood sugar in obese people with metabolic syndrome.
- Nonalcoholic fatty liver disease (NAFLD). Research suggests that drinking green tea daily for 12 weeks does not affect body weight or body mass but does reduce body fat percentage and fatty liver disease severity in people with NAFLD.
- Obesity. There is conflicting evidence about the effects of green tea in obese people. Some early research shows that certain specific green tea extracts (AR25, Exolise, Arkopharma, Carros, France; Sunphenon 90LB, Taiyo Kagaku Ltd, Yokkaichi, Japan; Herbal One Green Tea Extract, Herbal One Co., Ltd., Nakornprathom, Thailand) reduce weight in obese people. Other early research suggests that drinking green tea or green tea-containing beverages can reduce body weight and body mass index (BMI) in obese adults or children. Also, multi-ingredient products containing green tea might increase weight loss in obese or overweight adults. The effect of green tea on weight loss seems to be linked with the amount of catechins or caffeine contained in the beverage or supplement. However, some research suggests that taking green tea extracts or drinking green tea does not reduce body weight or BMI. Overall, research suggests that taking green tea extract along with caffeine seems to slightly reduce BMI, body weight and waist circumference compared to caffeine alone. But, taking green tea extract without caffeine does not seem to reduce weight.
- Mouth cancer. Population research suggests that drinking green tea is linked with a reduced risk of developing mouth cancer. Also, early research suggests that taking green tea extract three times daily after meals for 12 weeks increases healing responses in people with mouth cancer.
- Pancreatic cancer. Population research suggests that drinking green tea is linked to a reduced risk of pancreatic cancer.
- Gum disease (periodontal disease). Chewing candy that contains green tea extract seems to control plaque build-up on the teeth and reduce gum swelling. Also population research suggests that drinking green tea is linked with a reduced risk of gum disease. Also, applying a gel containing green tea extract improves symptoms in people with long-term gum disease.
- Pneumonia. Population research suggests that Japanese women who drink green tea have a lower risk of death from pneumonia compared to those who don't drink green tea.
- Pain after surgery. Research suggests that using a mouthwash containing green tea extract twice daily beginning the day after tooth removal surgery reduces pain and the need to use painkillers.
- Prostate cancer. Some research suggests that men who drink more green tea or who take products containing green tea antioxidants seem to have a lower risk of developing prostate cancer. But conflicting research exists. Green tea or green tea extracts do not seem to slow the progression of prostate cancer that has already been diagnosed.
- Stress. Early research suggests that taking a specific brand of green tea extract (Teavigo, DSM, Netherlands) by mouth for 7 days reduces stress and increases calmness in healthy people.
- Stroke. According to one study in Japan, drinking 3 cups of green tea daily seems to be linked with a lower risk of having a stroke compared to drinking one cup or no tea.
- Athlete's foot. Research suggests that using a footbath containing green tea extract (Sunphenon BG-3,Taiyo Kagaku Co. Ltd., Yokkaichi, Mie, Japan) for 15 minutes once daily for 12 weeks does not improve symptoms of athletes foot, but does improve skin condition.
- Inflammatory bowel disease (ulcerative colitis). Early research suggests that taking a specific green tea product (Polyphenon E, Mitsui-Norin, Fujieda, Japan) twice daily for 8 weeks might improve inflammatory bowel disease and help people with this condition achieve remission.
- Upper respiratory tract infection. Early research suggests that gargling and swallowing green tea (Morgentau, Ronnefeld KG, Germany) over 4 days is less effective than labdanum lozenges (CYSTUS052, Dr Pandalis Urheimische Medizin GmbH & Co. KG, Germany) for reducing symptoms of upper respiratory tract infections.
- Wrinkled skin. Some early research suggests that taking green tea antioxidants twice daily for 2 years does not reduce the signs of sun damage to the face in women. Also, applying a green tea cream and taking green tea by mouth daily seems to improve some aspects of skin aging in women, but overall appearance of skin does not seem to improve. However, some early research shows that drinking a beverage containing green tea antioxidants improves skin roughness, hydration, and elasticity in middle-aged women.
- Other conditions.
The useful parts of green tea are the leaf bud, leaf, and stem. Green tea is not fermented and is produced by steaming fresh leaves at high temperatures. During this process, it is able to maintain important molecules called polyphenols, which seem to be responsible for many of the benefits of green tea.
Polyphenols might be able to prevent inflammation and swelling, protect cartilage between the bones, and lessen joint degeneration. They also seem to be able to fight human papilloma virus (HPV) infections and reduce the growth of abnormal cells in the cervix (cervical dysplasia). Research cannot yet explain how this works.
Green tea contains 2% to 4% caffeine, which affects thinking and alertness, increases urine output, and may improve the function of brain messengers important in Parkinson's disease. Caffeine is thought to stimulate the nervous system, heart, and muscles by increasing the release of certain chemicals in the brain called "neurotransmitters."
Antioxidants and other substances in green tea might help protect the heart and blood vessels.
Green tea is LIKELY SAFE for most adults when consumed as a drink in moderate amounts or when green tea extract is applied to the skin as a specific ointment (Veregen, Bradley Pharmaceuticals), short-term. Green tea extract is POSSIBLY SAFE for most people when taken by mouth for up to 2 years, when applied to the skin as other ointments short-term, or when used as a mouthwash short-term. In some people, green tea can cause stomach upset and constipation. Green tea extracts have been reported to cause liver and kidney problems in rare cases.
Green tea is POSSIBLY UNSAFE when taken by mouth long-term or in high-doses. It can cause side effects because of the caffeine. These side effects can range from mild to serious and include headache, nervousness, sleep problems, vomiting, diarrhea, irritability, irregular heartbeat, tremor, heartburn, dizziness, ringing in the ears, convulsions, and confusion. Green tea seems to reduce the absorption of iron from food. Drinking very high doses of green tea is LIKELY UNSAFE and can actually be fatal. The fatal dose of caffeine in green tea is estimated to be 10-14 grams (150-200 mg per kilogram). Serious toxicity can occur at lower doses.
Special Precautions & Warnings:Children: Green tea is POSSIBLY SAFE for children when used in amounts commonly found in foods and beverages or when used for gargling three times daily for up to 90 days.
Pregnancy and breast-feeding: If you are pregnant or breast-feeding, green tea in small amounts - about 2 cups per day - is POSSIBLY SAFE. This amount of green tea provides about 200 mg of caffeine. However, drinking more than 2 cups of green tea per day is POSSIBLY UNSAFE. Consuming more than 2 cups of green tea daily has been linked to an increased risk of miscarriage and other negative effects due to the caffeine content. Also, green tea might increase the risk of birth defects associated with folic acid deficiency. In women who are nursing, caffeine passes into breast milk and can affect a nursing infant. Don't drink an excessive amount of green tea if you are pregnant or breast-feeding.
Anxiety disorders: The caffeine in green tea might make anxiety worse.
Bleeding disorders: Caffeine in green tea might increase the risk of bleeding. Don't drink green tea if you have a bleeding disorder.
Heart conditions: Caffeine in green tea might cause irregular heartbeat.
Diabetes: Caffeine in green tea might affect blood sugar control. If you drink green tea and have diabetes, monitor your blood sugar carefully.
Diarrhea: Green tea contains caffeine. The caffeine in green tea, especially when taken in large amounts, can worsen diarrhea.
Glaucoma: Drinking green tea increases pressure inside the eye. The increase occurs within 30 minutes and lasts for at least 90 minutes.
High blood pressure: The caffeine in green tea might increase blood pressure in people with high blood pressure. However, this does not seem to occur in people who regularly drink green tea or other products that contain caffeine.
Liver disease: Green tea extract supplements have been linked to several cases of liver damage. Green tea extracts might make liver disease worse.
Weak bones (osteoporosis): Drinking green tea can increase the amount of calcium that is flushed out in the urine. Caffeine should be limited to less than 300 mg per day (approximately 2-3 cups of green tea). It is possible to make up for some calcium loss caused by caffeine by taking calcium supplements.
AmphetaminesInteraction Rating: Major Do not take this combination.
Stimulant drugs such as amphetamines speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.
CocaineInteraction Rating: Major Do not take this combination.
Stimulant drugs such as cocaine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.
EphedrineInteraction Rating: Major Do not take this combination.
Stimulant drugs speed up the nervous system. Caffeine (contained in green tea) and ephedrine are both stimulant drugs. Taking green tea along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.
Nadolol (Corgard)Interaction Rating: Major Do not take this combination.
Green tea might decrease how much nadolol (Corgard) the body absorbs. Taking green tea along with nadolol (Corgard) might decrease the effectiveness of nadolol (Corgard).
Adenosine (Adenocard)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. The caffeine in green tea might block the effects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart, called a cardiac stress test. Stop consuming green tea or other caffeine-containing products at least 24 hours before a cardiac stress test.
Antibiotics (Quinolone antibiotics)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with green tea can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.
Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).
Birth control pills (Contraceptive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking green tea along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.
Bortezomib (Velcade)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Bortezomib (Velcade) is used in certain types of cancers. Green tea might interact with bortezomib (Velcade) and decrease its effectiveness for treating certain types of cancer. If you take bortezomib (Velcade) avoid taking green tea products.
Cimetidine (Tagamet)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with green tea might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.
Clozapine (Clozaril)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down clozapine (Clozaril) to get rid of it. The caffeine in green tea seems to decrease how quickly the body breaks down clozapine (Clozaril). Taking green tea along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).
Dipyridamole (Persantine)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. The caffeine in green tea might block the affectseffects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart called a cardiac stress test. Stop drinking green tea or other caffeine-containing products at least 24 hours before a cardiac stress test.
Disulfiram (Antabuse)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down caffeine to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking green tea (which contains caffeine) along with disulfiram (Antabuse) might increase the effects and side effects of caffeine, including jitteriness, hyperactivity, irritability, and others.
EstrogensInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking estrogen pills and drinking green tea can cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogen pills, limit your caffeine intake.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Fluvoxamine (Luvox)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking green tea along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine.
LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Your body naturally gets rid of lithium. The caffeine in green tea can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping caffeine too quickly can increase the side effects of lithium.
Medications for asthma (Beta-adrenergic agonists)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. Caffeine can stimulate the heart. Some medications for asthma can also stimulate the heart. Taking caffeine with some medications for asthma might cause too much stimulation and cause heart problems.
Medications for depression (MAOIs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Caffeine in green tea can stimulate the body. Some medications used for depression can also stimulate the body. Taking green tea that contains caffeine along with some medications for depression might cause serious side effects including fast heartbeat, high blood pressure, nervousness, and others.
Medications moved by pumps in cells (Organic Anion-Transporting Polypeptide Substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are moved by pumps in cells. Green tea might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective.
Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, nadolol (Corgard), paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).
Medications that can harm the liver (Hepatotoxic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea extracts might harm the liver. Taking green tea extracts along with medication that might also harm the liver can increase the risk of liver damage. Do not take green tea extracts if you are taking a medication that can harm the liver.
Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin) , lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea might slow blood clotting. Taking green tea along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include ardeparin (Normiflo), aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), dipyridamole (Persantine), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Medications used to treat cancer (Boronic acid-based proteasome inhibitors)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea might interact with some medications used to treat cancer (boronic acid-based proteasome inhibitors). This might decrease its effectiveness of these medications for treating certain types of cancer. If you take one of these medications for cancer, avoid taking green tea products. Some of these drugs include bortezomib (Velcade).
NicotineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stimulant drugs such as nicotine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems, including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.
Pentobarbital (Nembutal)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The stimulant effects of the caffeine in green tea can block the sleep-producing effects of pentobarbital (Nembutal).
PhenylpropanolamineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking green tea and phenylpropanolamine together might cause too much stimulation and increase heartbeat, increase blood pressure, and cause nervousness.
Riluzole (Rilutek)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down riluzole (Rilutek) to get rid of it. Drinking green tea can decrease how quickly the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole.
Stimulant drugsInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stimulant drugs speed up the nervous system and can make you feel jittery and speed up your heartbeat. Green tea contains caffeine, which can also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
TheophyllineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking green tea along with theophylline might increase the effects and side effects of theophylline.
Verapamil (Calan, Covera, Isoptin, Verelan)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Drinking green tea and taking verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for caffeine including jitteriness, headache, and an increased heartbeat.
Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Warfarin (Coumadin) is used to slow blood clotting. Large amounts of green tea have been reported to decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. It is unclear why this interaction might occur. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
AlcoholInteraction Rating: Minor Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking green tea along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.
Fluconazole (Diflucan)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine and cause caffeine to stay in the body too long. Taking fluconazole (Diflucan) along with green tea might increase the risk of side effects such as nervousness, anxiety, and insomnia.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Green tea might decrease how quickly the liver breaks down some medications. Taking green tea while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. However, it is not known if this is a big concern. Talk to your healthcare provider if you are taking any medications that are changed by the liver.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. There is conflicting evidence that caffeine might either increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. Taking some medications for diabetes along with caffeine might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Mexiletine (Mexitil)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with green tea might increase the caffeine effects and side effects of green tea.
Midazolam (Versed)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
The body breaks down midazolam (Versed) to get rid of it. Green tea might decrease how quickly the body breaks down midazolam (Versed). Taking green tea along with midazolam (Versed) might increase the effects and side effects of midazolam (Versed). However, it is not known if this is a big concern. Talk with you healthcare provider if you are taking midazolam.
Nicardipine (Cardene)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
A chemical in green tea called EGCG might increase how much nicardipine is absorbed in the body. In theory, green tea might increase the effects and side effects of nicardipine. But it's not clear if this is a real concern.
Terbinafine (Lamisil)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
The body breaks down the caffeine in green tea to get rid of it. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine. Taking green tea along with terbinafine (Lamisil) can increase the risk of caffeine side effects including jitteriness, headache, increased heartbeat, and other effects.
The following doses have been studied in scientific research:
- For high cholesterol: Green tea or green tea extracts containing 150 to 2500 mg catechins, taken in single or 2 divided doses daily for up to 24 weeks, has been used.
- For abnormal development of cells of the cervix (cervical dysplasia): 200 mg of green tea extract, taken by mouth daily along with a green tea ointment applied twice weekly for 8-12 weeks, has been used.
- For high blood pressure: A green tea drink, made by boiling a 3 gram tea bag with 150 mL water, has been used three times daily about 2 hours after each meal for 4 weeks. Also, 379 mg of a specific product containing green tea extract (Olimp Labs, Debica, Poland), taken daily with the morning meal for 3 months, has been used.
- For low blood pressure: 400 mL of green tea taken before lunch has been used.
- For thick, white patches on the gums (oral leukoplakia): 3 grams of mixed green tea taken by mouth and applied to the skin for 6 months has been used.
- For osteoporosis: Capsules containing 500 mg of green tea polyphenols, taken twice daily alone or while practicing tai chi for 60 minutes three times weekly for 24 weeks, has been used.
- For genital warts: A specific green tea extract ointment (Veregen, Bradley Pharmaceuticals; Polyphenon E ointment 15%, MediGene AG) applied three times daily to warts for up to 16 weeks, has been used. This product is FDA-approved for treating this condition.
- For abnormal development of cells of the cervix (cervical dysplasia): A green tea ointment has been used alone twice weekly, or in combination with 200 mg of green tea extract taken by mouth daily for 8-12 weeks.
- For thick, white patches on the gums (oral leukoplakia): 3 grams of mixed green tea taken by mouth and applied to the skin for 6 months has been used.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Hauber, I., Hohenberg, H., Holstermann, B., Hunstein, W., and Hauber, J. The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection. Proc.Natl.Acad.Sci.U.S.A 6-2-2009;106(22):9033-9038. View abstract.
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Hemelt, M., Hu, Z., Zhong, Z., Xie, L. P., Wong, Y. C., Tam, P. C., Cheng, K. K., Ye, Z., Bi, X., Lu, Q., Mao, Y., Zhong, W. D., and Zeegers, M. P. Fluid intake and the risk of bladder cancer: results from the South and East China case-control study on bladder cancer. Int.J.Cancer 8-1-2010;127(3):638-645. View abstract.
Henning, S. M., Aronson, W., Niu, Y., Conde, F., Lee, N. H., Seeram, N. P., Lee, R. P., Lu, J., Harris, D. M., Moro, A., Hong, J., Pak-Shan, L., Barnard, R. J., Ziaee, H. G., Csathy, G., Go, V. L., Wang, H., and Heber, D. Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr 2006;136(7):1839-1843. View abstract.
Henning, S. M., Niu, Y., Lee, N. H., Thames, G. D., Minutti, R. R., Wang, H., Go, V. L., and Heber, D. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr 2004;80(6):1558-1564. View abstract.
Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C., and Chiotelli, E. Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products. Osteoarthritis.Cartilage. 2011;19(1):1-21. View abstract.
Hirano, R., Momiyama, Y., Takahashi, R., Taniguchi, H., Kondo, K., Nakamura, H., and Ohsuzu, F. Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease. Am.J Cardiol. 11-15-2002;90(10):1150-1153. View abstract.
Hirano-Ohmori, R., Takahashi, R., Momiyama, Y., Taniguchi, H., Yonemura, A., Tamai, S., Umegaki, K., Nakamura, H., Kondo, K., and Ohsuzu, F. Green tea consumption and serum malondialdehyde-modified LDL concentrations in healthy subjects. J Am Coll.Nutr 2005;24(5):342-346. View abstract.
Hirao, K., Yumoto, H., Nakanishi, T., Mukai, K., Takahashi, K., Takegawa, D., and Matsuo, T. Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells. Life Sci. 4-24-2010;86(17-18):654-660. View abstract.
Hirasawa, M., Takada, K., Makimura, M., and Otake, S. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res 2002;37(6):433-438. View abstract.
Horiba, N., Maekawa, Y., Ito, M., Matsumoto, T., and Nakamura, H. A pilot study of Japanese green tea as a medicament: antibacterial and bactericidal effects. J Endod. 1991;17(3):122-124. View abstract.
Hsu, C. H., Liao, Y. L., Lin, S. C., Tsai, T. H., Huang, C. J., and Chou, P. Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial. Altern.Med.Rev. 2011;16(2):157-163. View abstract.
Hsu, C. H., Tsai, T. H., Kao, Y. H., Hwang, K. C., Tseng, T. Y., and Chou, P. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 2008;27(3):363-370. View abstract.
Hsu, J., Skover, G., and Goldman, M. P. Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants. J Drugs Dermatol. 2007;6(11):1141-1148. View abstract.
Hunt, K. J., Hung, S. K., and Ernst, E. Botanical extracts as anti-aging preparations for the skin: a systematic review. Drugs Aging 12-1-2010;27(12):973-985. View abstract.
Hursel, R. and Westerterp-Plantenga, M. S. Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss. Am J Clin Nutr 2009;89(3):822-830. View abstract.
Ichinose, T., Nomura, S., Someya, Y., Akimoto, S., Tachiyashiki, K., and Imaizumi, K. Effect of endurance training supplemented with green tea extract on substrate metabolism during exercise in humans. Scand.J Med Sci.Sports 3-10-2010; View abstract.
Imai, K., Suga, K., and Nakachi, K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev.Med 1997;26(6):769-775. View abstract.
Inami, S., Takano, M., Yamamoto, M., Murakami, D., Tajika, K., Yodogawa, K., Yokoyama, S., Ohno, N., Ohba, T., Sano, J., Ibuki, C., Seino, Y., and Mizuno, K. Tea catechin consumption reduces circulating oxidized low-density lipoprotein. Int Heart J 2007;48(6):725-732. View abstract.
Inoue, M., Robien, K., Wang, R., Van Den Berg, D. J., Koh, W. P., and Yu, M. C. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis 2008;29(10):1967-1972. View abstract.
Janjua, R., Munoz, C., Gorell, E., Rehmus, W., Egbert, B., Kern, D., and Chang, A. L. A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin. Dermatol.Surg. 2009;35(7):1057-1065. View abstract.
Jankun, J., Selman, S. H., Swiercz, R., and Skrzypczak-Jankun, E. Why drinking green tea could prevent cancer. Nature 6-5-1997;387(6633):561. View abstract.
Javaid, A. and Bonkovsky, H. L. Hepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): a growing concern. J Hepatol 2006;45(2):334-335. View abstract.
Ji, B. T., Chow, W. H., Hsing, A. W., McLaughlin, J. K., Dai, Q., Gao, Y. T., Blot, W. J., and Fraumeni, J. F., Jr. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer 1-27-1997;70(3):255-258. View abstract.
Jin, X., Zheng, R. H., and Li, Y. M. Green tea consumption and liver disease: a systematic review. Liver Int 2008;28(7):990-996. View abstract.
Josic, J., Olsson, A. T., Wickeberg, J., Lindstedt, S., and Hlebowicz, J. Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. Nutr.J. 2010;9:63. View abstract.
Jowko, E., Sacharuk, J., Balasinska, B., Ostaszewski, P., Charmas, M., and Charmas, R. Green tea extract supplementation gives protection against exercise-induced oxidative damage in healthy men. Nutr.Res. 2011;31(11):813-821. View abstract.
Jurgens, T. M., Whelan, A. M., Killian, L., Doucette, S., Kirk, S., and Foy, E. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane.Database.Syst.Rev. 2012;12:CD008650. View abstract.
Kakuta, Y., Nakaya, N., Nagase, S., Fujita, M., Koizumi, T., Okamura, C., Niikura, H., Ohmori, K., Kuriyama, S., Tase, T., Ito, K., Minami, Y., Yaegashi, N., and Tsuji, I. Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control 2009;20(5):617-624. View abstract.
Kalus, U., Kiesewetter, H., and Radtke, H. Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract. Phytother.Res. 2010;24(1):96-100. View abstract.
Karth, A., Holoshitz, N., Kavinsky, C. J., Trohman, R., and McBride, B. F. A case report of atrial fibrillation potentially induced by hydroxycut: a multicomponent dietary weight loss supplement devoid of sympathomimetic amines. J.Pharm.Pract. 2010;23(3):245-249. View abstract.
Katiyar, S. K., Matsui, M. S., Elmets, C. A., and Mukhtar, H. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem.Photobiol. 1999;69(2):148-153. View abstract.
Kato, M. T., Leite, A. L., Hannas, A. R., and Buzalaf, M. A. Gels containing MMP inhibitors prevent dental erosion in situ. J Dent.Res. 2010;89(5):468-472. View abstract.
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Kikuchi, N., Ohmori, K., Shimazu, T., Nakaya, N., Kuriyama, S., Nishino, Y., Tsubono, Y., and Tsuji, I. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study. Br.J Cancer 8-7-2006;95(3):371-373. View abstract.
Kim, W., Jeong, M. H., Cho, S. H., Yun, J. H., Chae, H. J., Ahn, Y. K., Lee, M. C., Cheng, X., Kondo, T., Murohara, T., and Kang, J. C. Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers. Circ.J 2006;70(8):1052-1057. View abstract.
Kohler, M., Pavy, A., and van den Heuvel, C. The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation. J Sleep Res. 2006;15(4):358-368. View abstract.
Komatsu, T., Nakamori, M., Komatsu, K., Hosoda, K., Okamura, M., Toyama, K., Ishikura, Y., Sakai, T., Kunii, D., and Yamamoto, S. Oolong tea increases energy metabolism in Japanese females. J Med Invest 2003;50(3-4):170-175. View abstract.
Kristen, A. V., Lehrke, S., Buss, S., Mereles, D., Steen, H., Ehlermann, P., Hardt, S., Giannitsis, E., Schreiner, R., Haberkorn, U., Schnabel, P. A., Linke, R. P., Rocken, C., Wanker, E. E., Dengler, T. J., Altland, K., and Katus, H. A. Green tea halts progression of cardiac transthyretin amyloidosis: an observational report. Clin.Res.Cardiol. 2012;101(10):805-813. View abstract.
Kuo, Y. C., Yu, C. L., Liu, C. Y., Wang, S. F., Pan, P. C., Wu, M. T., Ho, C. K., Lo, Y. S., Li, Y., and Christiani, D. C. A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan. Cancer Causes Control 2009;20(1):57-65. View abstract.
Kurahashi, N., Inoue, M., Iwasaki, M., Sasazuki, S., and Tsugane, S. Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan. Cancer Sci. 2009;100(2):294-91. View abstract.
Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., and Tsugane, S. Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am J Epidemiol. 1-1-2008;167(1):71-77. View abstract.
Kuriyama, S. The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies. J Nutr. 2008;138(8):1548S-1553S. View abstract.
Kushima, Y., Iida, K., Nagaoka, Y., Kawaratani, Y., Shirahama, T., Sakaguchi, M., Baba, K., Hara, Y., and Uesato, S. Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol.Pharm.Bull. 2009;32(5):899-904. View abstract.
Kushiyama, M., Shimazaki, Y., Murakami, M., and Yamashita, Y. Relationship between intake of green tea and periodontal disease. J Periodontol. 2009;80(3):372-377. View abstract.
Lang, M., Henson, R., Braconi, C., and Patel, T. Epigallocatechin-gallate modulates chemotherapy-induced apoptosis in human cholangiocarcinoma cells. Liver Int 2009;29(5):670-677. View abstract.
Langley, P. C. A cost-effectiveness analysis of sinecatechins in the treatment of external genital warts. J.Med.Econ. 2010;13(1):1-7. View abstract.
Laurie, S. A., Miller, V. A., Grant, S. C., Kris, M. G., and Ng, K. K. Phase I study of green tea extract in patients with advanced lung cancer. Cancer Chemother.Pharmacol. 2005;55(1):33-38. View abstract.
Levites, Y., Amit, T., Mandel, S., and Youdim, M. B. Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J 2003;17(8):952-954. View abstract.
Li, G. X., Chen, Y. K., Hou, Z., Xiao, H., Jin, H., Lu, G., Lee, M. J., Liu, B., Guan, F., Yang, Z., Yu, A., and Yang, C. S. Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 2010;31(5):902-910. View abstract.
Li, R., Huang, Y. G., Fang, D., and Le, W. D. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci.Res. 12-1-2004;78(5):723-731. View abstract.
Liatsos, G. D., Moulakakis, A., Ketikoglou, I., and Klonari, S. Possible green tea-induced thrombotic thrombocytopenic purpura. Am.J Health Syst.Pharm. 4-1-2010;67(7):531-534. View abstract.
Lin, C. L., Chen, T. F., Chiu, M. J., Way, T. D., and Lin, J. K. Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation. Neurobiol.Aging 2009;30(1):81-92. View abstract.
Lonac, M. C., Richards, J. C., Schweder, M. M., Johnson, T. K., and Bell, C. Influence of Short-Term Consumption of the Caffeine-Free, Epigallocatechin-3-Gallate Supplement, Teavigo, on Resting Metabolism and the Thermic Effect of Feeding. Obesity.(Silver.Spring) 8-19-2010; View abstract.
Maeda-Yamamoto, M., Ema, K., Monobe, M., Shibuichi, I., Shinoda, Y., Yamamoto, T., and Fujisawa, T. The efficacy of early treatment of seasonal allergic rhinitis with benifuuki green tea containing O-methylated catechin before pollen exposure: an open randomized study. Allergol.Int 2009;58(3):437-444. View abstract.
Magalhaes, A. C., Wiegand, A., Rios, D., Hannas, A., Attin, T., and Buzalaf, M. A. Chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ. J Dent. 2009;37(12):994-998. View abstract.
Mahmood, T., Akhtar, N., Khan, B. A., Shoaib Khan, H. M., and Saeed, T. Changes in skin mechanical properties after long-term application of cream containing green tea extract. Aging Clin.Exp.Res. 2011;23(5-6):333-336. View abstract.
Maki, K. C., Reeves, M. S., Farmer, M., Yasunaga, K., Matsuo, N., Katsuragi, Y., Komikado, M., Tokimitsu, I., Wilder, D., Jones, F., Blumberg, J. B., and Cartwright, Y. Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutr 2009;139(2):264-270. View abstract.
Mangine, G. T., Gonzalez, A. M., Wells, A. J., McCormack, W. P., Fragala, M. S., Stout, J. R., and Hoffman, J. R. The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: a double-blind, randomized control trial. Lipids Health Dis. 2012;11:127. View abstract.
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Matsumoto, K., Yamada, H., Takuma, N., Niino, H., and Sagesaka, Y. M. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC.Complement Altern.Med. 2011;11:15. View abstract.
Matsuyama, T., Tanaka, Y., Kamimaki, I., Nagao, T., and Tokimitsu, I. Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children. Obesity.(Silver.Spring) 2008;16(6):1338-1348. View abstract.
Melgarejo, E., Medina, M. A., Sanchez-Jimenez, F., and Urdiales, J. L. Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro. Br.J Pharmacol. 2009;158(7):1705-1712. View abstract.
Meltzer, S. M., Monk, B. J., and Tewari, K. S. Green tea catechins for treatment of external genital warts. Am J Obstet.Gynecol. 2009;200(3):233-237. View abstract.
Miller, R. J., Jackson, K. G., Dadd, T., Mayes, A. E., Brown, A. L., Lovegrove, J. A., and Minihane, A. M. The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Mol.Nutr.Food Res. 2012;56(6):966-975. View abstract.
Miller, R. J., Jackson, K. G., Dadd, T., Nicol, B., Dick, J. L., Mayes, A. E., Brown, A. L., and Minihane, A. M. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. Eur.J.Nutr. 2012;51(1):47-55. View abstract.
Mineharu, Y., Koizumi, A., Wada, Y., Iso, H., Watanabe, Y., Date, C., Yamamoto, A., Kikuchi, S., Inaba, Y., Toyoshima, H., Kondo, T., and Tamakoshi, A. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. J Epidemiol.Community Health 7-14-2010; View abstract.
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Nagao, T., Meguro, S., Hase, T., Otsuka, K., Komikado, M., Tokimitsu, I., Yamamoto, T., and Yamamoto, K. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity.(Silver.Spring) 2009;17(2):310-317. View abstract.
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Nguyen, M. M., Ahmann, F. R., Nagle, R. B., Hsu, C. H., Tangrea, J. A., Parnes, H. L., Sokoloff, M. H., Gretzer, M. B., and Chow, H. H. Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities. Cancer Prev.Res.(Phila) 2012;5(2):290-298. View abstract.
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Oyama, J., Maeda, T., Kouzuma, K., Ochiai, R., Tokimitsu, I., Higuchi, Y., Sugano, M., and Makino, N. Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers. Circ.J 2010;74(3):578-588. View abstract.
Oyama, J., Maeda, T., Sasaki, M., Kozuma, K., Ochiai, R., Tokimitsu, I., Taguchi, S., Higuchi, Y., and Makino, N. Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers. Intern.Med. 2010;49(23):2553-2559. View abstract.
Pan, T., Fei, J., Zhou, X., Jankovic, J., and Le, W. Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life Sci. 1-17-2003;72(9):1073-1083. View abstract.
Panza, V. S., Wazlawik, E., Ricardo, Schutz G., Comin, L., Hecht, K. C., and da Silva, E. L. Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 2008;24(5):433-442. View abstract.
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Park, C. S., Kim, W., Woo, J. S., Ha, S. J., Kang, W. Y., Hwang, S. H., Park, Y. W., Kim, Y. S., Ahn, Y. K., Jeong, M. H., and Kim, W. Green tea consumption improves endothelial function but not circulating endothelial progenitor cells in patients with chronic renal failure. Int J Cardiol. 12-2-2009; View abstract.
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