Doctor's Notes on Gynecomastia
Gynecomastia is enlargement of mail breast tissue due to enlarged glandular tissue, not due to fat. Gynecomastia is a sign and symptom of a hormonal imbalance.
Although gynecomastia may be caused transiently in the normal development of boys, it usually resolves on its own. Other causes, such as medical conditions or medical treatments, may not resolve spontaneously. Causes associated with gynecomastia development include cirrhosis, malnutrition, chronic kidney failure, disorders of the male sex organs, aging, testicular cancer, hyperthyroidism, and anti-androgen medical treatments. Other associated causes are alcohol use and some drugs of abuse like heroin.
Medications associated with causing gynecomastia include spironolactone, ACE inhibitors, some antibiotics, anti-ulcer drugs, some anti-hypertensive drugs, and HAART (HIV treatment).
Male breast cancer usually causes gynecomastia only in one breast and may include a lump or feeling of hard tissue in the breast; other signs and symptoms may be breast skin changes, nipple discharge, and enlargement of underarm lymph nodes.
What Are the Treatments for Gynecomastia?
Usually, once the underlying problem is diagnosed (see above) and treated, the gynecomastia lessens and requires no additional treatments. However, a consultation with an endocrinologist may be recommended. Surgery is not recommended unless gynecomastia is causing severe pain, tenderness, and/or embarrassment. Counseling may be recommended with some boys and men coping with this problem.
Some doctors may suggest using raloxifene or tamoxifen as off-label medical treatments; again, consultation with an endocrinologist may be recommended before such use.
Low Testosterone (Low T) : Test Your IQ of Men's Conditions Quiz

Testosterone is a chemical found only in men.
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Cirrhosis of the Liver
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Hyperthyroidism
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Low Testosterone (Low-T)
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Testicle Infection (Epididymitis)
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Testicular Pain (Right, Left Side, and Back Pain)
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Testicular Torsion
Testicular torsion is a painful condition caused by the twisting of the spermatic cord, which causes a loss of blood flow to the testicle. It is a surgical emergency that may result in the loss of the testicle. The main cause is an anatomical abnormality called the bell clapper deformity. Symptoms include testicular pain, sudden swelling, nausea, vomiting, abdominal pain, or fever. Treatment for testicular torsion is surgery.
REFERENCE:
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.