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What other names is Hordenine known by?

Anhaline, N,N-dimethyltyramine, Peyocactin.

What is Hordenine?

Hordenine is a chemical naturally found in barley (Hordeum vulgare). It is similar in chemical structure to stimulants found in bitter orange. Hordenine is included in many dietary supplements used for athletic performance and weight loss. It can also be found in algae, cacti, and some grass species.

People take hordenine by mouth for improving athletic performance and weight loss.

Insufficient Evidence to Rate Effectiveness for...

  • Athletic performance.
  • Weight loss.
More evidence is needed to rate hordenine for these uses.

How does Hordenine work?

Hordenine is similar in chemical structure to stimulants found in bitter orange. Some research shows that it might stimulate the central nervous system, and increase heart rate, blood pressure, and breathing rate. These effects seem to be short-lived and require high doses.

Are there safety concerns?

Hordenine is POSSIBLY UNSAFE when taken by mouth. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hordenine if you are pregnant or breast feeding. Stay on the safe side and avoid use.

High blood pressure: Hordenine is similar to stimulants found in bitter orange. In theory, taking hordenine might make high blood pressure worse.

Kidney stones: Taking hordenine might increase the risk for kidney stones.

Surgery: Hordenine might interfere with surgery by increasing blood pressure and heart rate. Stop taking hordenine at least 2 weeks before surgery.

Are there any interactions with medications?

Medications for depression (MAOIs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Hordenine might stimulate the body. Some medications used for depression can increase chemicals that also have stimulant effects. Taking hordenine with these medications used for depression might cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others.

Some of these medications used for depression include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).

Stimulant drugsInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Hordenine might also speed up the nervous system. In theory, taking hordenine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with hordenine.

Some stimulant drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.

Dosing considerations for Hordenine.

The appropriate dose of hordenine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hordenine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019

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