Symptoms and Signs of Hypopituitarism in Children

Medical Author:
Medically Reviewed on 10/19/2021

Doctor's Notes on Hypopituitarism in Children

Hypopituitarism in children is a condition in children (and adults) where the pituitary gland does not produce enough hormones of one or more types (ACTH, FSH, GH, TSH, ADH, and prolactin). In children, signs and symptoms vary with age, underlying cause, and hormone type; they may not be specific and may develop gradually. In newborns, signs and symptoms include

Older infants and children may have one or more of these signs and symptoms:

Hypopituitarism in children is caused by genetic (inherited) problems, a defective, underdeveloped, or absent pituitary gland, birth trauma, and central nervous system defects. Hypopituitarism in children can be acquired or caused by the following conditions: radiation to the head, brain tumors, or any condition that can alter the pituitary gland like infection by TB bacteria or infiltration by sarcoidosis.

What Is the Treatment for Hypopituitarism in Children?

The main treatments for hypopituitarism in children are medications to replace hormones that the pituitary gland has slowed or stopped producing or influencing, given by mouth, patch, or injection, with the goal of returning the patient's hormone levels to normal levels:

Also, pituitary tumors can be treated by surgical removal and radiation; other medications may be added to control underlying causes.


Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.