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What other names is Ipriflavone known by?

FL-113, 7-isopropoxyisoflavone, 7-Isopropoxy-Isoflavone, Ipriflavona, TC-80.

What is Ipriflavone?

Ipriflavone is made in the laboratory from another substance (daidzein) that is taken from soy. Soy is a plant.

Ipriflavone is used for preventing and treating weak bones (osteoporosis) in older women, preventing osteoporosis caused by certain medications, relieving pain associated with osteoporosis, and treating a bone disease called Paget's disease. It is also used for reducing bone loss caused by chronic kidney disease (renal osteodystrophy) and by paralysis associated with stroke. Researchers have found that paralyzed stroke patients have weaker bones on the affected side, possibly due to immobility as well as vitamin D deficiency. Vitamin D deficiency may stem from lack of exposure to sunlight.

Ipriflavone is also used by bodybuilders to increase metabolism.

Likely Effective for...

  • Treating and preventing weak bones (osteoporosis) in postmenopausal women. Taking ipriflavone in combination with 1000 mg of calcium daily can prevent loss of bone mineral density (BMD) in postmenopausal women with osteoporosis or low bone strength. There is some evidence that it might actually increase bone strength in some of these women. The effect seems to be determined by the amount of calcium that is taken along with the ipriflavone. One study using ipriflavone with only 500 mg per day of calcium found no effect on bone strength. But taking more than 1000 mg of calcium daily may increase the benefit.
    Taking ipriflavone in combination with estrogen also seems to prevent osteoporosis and increase bone strength in older women. Adding calcium makes the combination work even better.
  • Reducing pain associated with osteoporosis. Ipriflavone can also significantly reduce pain due to osteoporosis and seems to be as effective as inhaling a medication called calcitonin.
  • Reducing bone loss in people who have been paralyzed on one side of their body by stroke (hemiplegic stroke). Ipriflavone in combination with vitamin D seems to prevent bone loss significantly better than vitamin D alone in hemiplegic stroke patients with vitamin D deficiency.

Possibly Effective for...

  • Bone pain in people with Paget's disease.
  • Bone disease due to chronic kidney disease (renal osteodystrophy).

Insufficient Evidence to Rate Effectiveness for...

  • Increasing metabolism in bodybuilders.
  • Other conditions.
More evidence is needed to rate the effectiveness of ipriflavone for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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