Iritis may be a consequence of trauma (traumatic iritis) or nontraumatic causes. In a significant number of cases, no cause for the iritis is found.
- Blunt trauma to the eye can cause traumatic inflammation of the iris.
- Nontraumatic iritis is frequently associated with certain systemic diseases (diseases that affects multiple locations throughout the body), such as ankylosing spondylitis, Reiter syndrome, sarcoidosis, tuberculosis, inflammatory bowel disease, and psoriasis. Noteworthy of special attention is iritis associated with juvenile rheumatoid arthritis.
- Infectious causes may include Lyme disease, tuberculosis, toxoplasmosis, syphilis, and herpes simplex and herpes zoster viruses.
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