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Kinetin

What other names is Kinetin known by?

Cinetina, Kinerase, Kinetase, Kinetina, Kinétine, Kn, N-(2-furanylmethyl)-1H-purin-6-amine, N(6)furfuryladenine, 6-furfurylaminopurine, Quinetina.

What is Kinetin?

Kinetin is a cytokinin. Cytokinins are compounds that stimulate plants to grow. Kinetin is used to make medicine.

People apply kinetin directly to the skin to reduce the effects of skin aging including roughness, fine wrinkles, dilated blood vessels, and uneven pigmentation.

Kinetin is sometimes applied to the skin in combination with retinol palmitate to treat signs of aging.

Insufficient Evidence to Rate Effectiveness for...

  • An inner ear disorder called Meniere's disease. Early research suggests that filling the small cavity surrounding the middle ear bones with a solution of kinetin and the drug lidocaine improves symptoms such as hearing loss, ringing in the ear, and dizziness in many people with Meniere's disease.
  • Reducing the signs of skin aging.
  • Skin roughness.
  • Fine wrinkles.
  • Skin imperfections.
  • Other conditions.
More evidence is needed to rate the effectiveness of kinetin for these uses.

How does Kinetin work?

Kinetin prevents green plant leaves from turning brown. There is some information that suggests kinetin might prevent age-related changes in human skin by protecting the DNA in skin cells from damage (antioxidant effects) and decreasing skin water loss.

Are there safety concerns?

There is not enough information available to know if kinetin is safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of kinetin during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: There is some concern that kinetin might prolong bleeding time and increase the risk of bruising and bleeding in some people with bleeding disorders. If you have a bleeding disorder, use kinetin with caution.

Surgery: Kinetin might increase the risk of bleeding during and after surgery. Stop taking kinetin at least 2 weeks before a scheduled surgery.

Are there any interactions with medications?


Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Kinetin might slow blood clotting in some people. Taking kinetin along with medications that also slow clotting might increase the chances of bruising and bleeding in some people.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing considerations for Kinetin.

The appropriate dose of kinetin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for kinetin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019
References

Adunka, O., Moustaklis, E., Weber, A., May, A., von Ilberg, C., Gstoettner, W., and Kierner, A. C. Labyrinth anesthesia--a forgotten but practical treatment option in Meniere's disease. ORL J Otorhinolaryngol.Relat Spec. 2003;65(2):84-90. View abstract.

Barciszewski, J., Mielcarek, M., Stobiecki, M., Siboska, G., and Clark, B. F. Identification of 6-furfuryladenine (kinetin) in human urine. Biochem Biophys Res Commun. 12-9-2000;279(1):69-73. View abstract.

Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F., and Rattan, S. I. Evidence for the presence of kinetin in DNA and cell extracts. FEBS Lett 9-16-1996;393(2-3):197-200. View abstract.

Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F., and Rattan, S. I. Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA. Biochem Biophys Res Commun. 9-18-1997;238(2):317-319. View abstract.

Griffaut, B., Bos, R., Maurizis, J. C., Madelmont, J. C., and Ledoigt, G. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004;34(4):271-275. View abstract.

Hessemer, V., Hoppe, O., and Jacobi, K. W. [Effect of hyaluronidase on ocular circulatory changes caused by retrobulbar anesthesia]. Fortschr Ophthalmol. 1991;88(2):196-200. View abstract.

Hipkiss, A. R. On the "struggle between chemistry and biology during aging"--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention. Biogerontology. 2001;2(3):173-178. View abstract.

Honma, Y. and Ishii, Y. Differentiation of human myeloid leukemia cells by plant redifferentiation-inducing hormones. Leuk.Lymphoma 2002;43(9):1729-1735. View abstract.

Hsiao, G., Shen, M. Y., Lin, K. H., Chou, C. Y., Tzu, N. H., Lin, C. H., Chou, D. S., Chen, T. F., and Sheu, J. R. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol 4-4-2003;465(3):281-287. View abstract.

Ishii, Y., Hori, Y., Sakai, S., and Honma, Y. Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ. 2002;13(1):19-26. View abstract.

Ishii, Y., Kasukabe, T., and Honma, Y. Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim.Biophys Acta 9-10-2005;1745(2):156-165. View abstract.

Ishii, Y., Sakai, S., and Honma, Y. Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA. Biochim.Biophys Acta 12-7-2003;1643(1-3):11-24. View abstract.

Kligman, D. Cosmeceuticals. Dermatol Clin 2000;18(4):609-615. View abstract.

Kowalska, E. Influence of kinetin (6-furfurylo-amino-purine) on human fibroblasts in the cell culture. Folia Morphol.(Warsz.) 1992;51(2):109-118. View abstract.

Krohn, J., Seland, J. H., Hovding, G., Bertelsen, T., Aasved, H., and Haugen, O. H. Retrobulbar anesthesia with and without hyaluronidase in extracapsular cataract surgery. A prospective, randomized, double-blind study. Acta Ophthalmol.(Copenh) 1993;71(6):791-795. View abstract.

Sheu, J. R., Hsiao, G., Shen, M. Y., Chou, C. Y., Lin, C. H., Chen, T. F., and Chou, D. S. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196. View abstract.

Slaugenhaupt, S. A., Mull, J., Leyne, M., Cuajungco, M. P., Gill, S. P., Hims, M. M., Quintero, F., Axelrod, F. B., and Gusella, J. F. Rescue of a human mRNA splicing defect by the plant cytokinin kinetin. Hum.Mol.Genet. 2-15-2004;13(4):429-436. View abstract.

Bruneton J. Pharmacognosy Phytochemistry Medicinal Plants. 2nd ed. Paris, FR: Lavoisier, 1999:142.

Olsen A, Siboska GE, Clark BF, Rattan SI. N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Commun 1999;265:499-502. View abstract.

Rattan SI, Clark BF. Kinetin delays onset of aging characteristics in human fibroblasts. Biochem Biophys Res Commun 1994;201:665-72. View abstract.

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