©2018 WebMD, Inc. All rights reserved. eMedicineHealth does not provide medical advice, diagnosis or treatment. See Additional Information.

Lathyrus

What other names is Lathyrus known by?

Caley Pea, Chícharo Hirsuto, Chickling Vetch, Chick-Pea, Doncenón, Everlasting Pea, Flat-Podded Vetch, Gesse, Gesse Articulée, Gesse des Bois, Gesse Clymène, Gesse Commune, Gesse Chiche, Gesse Hérissée, Gesse Sauvage, Gesse Tubéreuse, Guisante de Olor, Jarosse, Lathyrus cicera, Lathyrus clymenum, Lathyrus hirsutus, Lathyrus incanus, Lathyrus odoratus, Lathyrus pusillus, Lathyrus sativus, Lathyrus sylvestris, Pois Carré, Pois de Senteur, Singletary Pea, Spanish Vetchling, Sweet Pea, Wild Pea.

What is Lathyrus?

Lathyrus is a plant. People use it as medicine.

Despite serious safety concerns, Lathyrus sativus is used in unleavened Indian bread. Lathyrus seeds are eaten as food and used as animal fodder throughout the world.

The flowers of sweet pea (Lathyrus odoratus) are grown for their color and fragrance.

Insufficient Evidence to Rate Effectiveness for...

  • Any medical use.
More evidence is needed to rate the effectiveness of lathyrus for these uses.

How does Lathyrus work?

There isn't enough information to know how lathyrus might work for any medical use.

Are there safety concerns?

Lathyrus is LIKELY UNSAFE when taken by mouth. It is poisonous to nerves. It can cause muscle rigidity, muscle spasms, weakness, paralysis of leg muscles, weak heartbeat, decreased breathing, seizures, and death.

Lathyrus poisoning and its complications are rare in western countries, yet they have been documented for more than a century in Europe, Africa, and Asia. Despite the attempt to ban the sale of Lathyrus sativus in several states of India, distribution continues. To deactivate the poison, several methods have been tried. Typically they involve soaking the seeds in water followed by steaming or sun drying. Roasting the seeds at high temperatures for twenty minutes also helps to destroy the poison. However, these methods are only 80-85% effective.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It's LIKELY UNSAFE to use lathyrus because it contains poisonous chemicals. Avoid use.

Dosing considerations for Lathyrus.

The appropriate dose of lathyrus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lathyrus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Health Solutions From Our Sponsors

Reviewed on 9/17/2019
References

Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328. View abstract.

Bell, E. A. Nonprotein amino acids of plants: significance in medicine, nutrition, and agriculture. J Agric.Food Chem 5-7-2003;51(10):2854-2865. View abstract.

Bonte, F. and Fiot, N. [Two epidemic diseases in Blois region in the 19th century]. Rev Hist Pharm (Paris) 1999;47(322):193-198. View abstract.

Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71. View abstract.

Cohn, D. F. and Streifler, M. Human neurolathyrism, a follow-up study of 200 patients. Part I: Clinical investigation. Schweiz.Arch Neurol.Neurochir.Psychiatr. 1981;128(1):151-156. View abstract.

Cohn, D. F. and Streifler, M. Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings. Arch.Toxicol.Suppl 1983;6:190-193. View abstract.

Conn, H. O., Rossle, M., Levy, L., and Glocker, F. X. Portosystemic myelopathy: spastic paraparesis after portosystemic shunting. Scand J Gastroenterol 2006;41(5):619-625. View abstract.

Delachambre, D., Betail, G., Guillot, J., Bernard-Griffiths, I., and Coulet, M. [Study of certain properties of the phytohemagglutinin isolated from Lathyrus odoratus L]. C.R.Seances Soc.Biol.Fil. 1971;165(9):1903-1907. View abstract.

Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. View abstract.

Durlach, J., Bac, P., Durlach, V., Durlach, A., Bara, M., and Guiet-Bara, A. Are age-related neurodegenerative diseases linked with various types of magnesium depletion? Magnes.Res 1997;10(4):339-353. View abstract.

Getahun, H., Lambein, F., and Van der, Stuyft P. ABO blood groups, grass pea preparation, and neurolathyrism in Ethiopia. Trans R.Soc Trop.Med Hyg 2002;96(6):700-703. View abstract.

Getahun, H., Lambein, F., Vanhoorne, M., and Van der, Stuyft P. Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine. Lancet 11-29-2003;362(9398):1808-1810. View abstract.

Grela Eugeniusz, R., Studzinski, T., and Winiarska, A. Lathyrism in people and animals . Publication of the Polish Society of Veterinary Sciences 2000;56(9):558-562.

Haimanot, R. T., Kidane, Y., Wuhib, E., Kalissa, A., Alemu, T., Zein, Z. A., and Spencer, P. S. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol. 1990;19(3):664-672. View abstract.

Haimanot, R. T., Kidane, Y., Wuhib, E., Kassina, A., Endeshaw, Y., Alemu, T., and Spencer, P. S. The epidemiology of lathyrism in north and central Ethiopia. Ethiop.Med J 1993;31(1):15-24. View abstract.

Haque, A., Hossain, M., Lambein, F., and Bell, E. A. Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh. Nat Toxins. 1997;5(1):43-46. View abstract.

Hugon, J., Ludolph, A. C., Spencer, P. S., Gimenez, Roldan S., and Dumas, J. L. Studies of the etiology and pathogenesis of motor neuron diseases. III. Magnetic cortical stimulation in patients with lathyrism. Acta Neurol.Scand 1993;88(6):412-416. View abstract.

Jansen, A., Vermeulen, A., van Toorenenbergen, A. W., and Dieges, P. H. Occupational asthma in horticulture caused by Lathyrus odoratus. Allergy Proc. 1995;16(3):135-139. View abstract.

Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. View abstract.

Lambein, F., Haque, R., Khan, J. K., Kebede, N., and Kuo, Y. H. From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism. Toxicon 1994;32(4):461-466. View abstract.

Lieberman, P. Preventing fatalities from anaphylaxis: an allergist-immunologist's perspective. Allergy Proc 1995;16(3):109-111. View abstract.

Lisiewska, Z., Korus, A., and Kmiecik, W. Changes in chemical composition during development of grass pea (Lathyrus sativus L.) seeds. Nahrung 2003;47(6):391-396. View abstract.

Lopez Aydillo, N. R. and Ramirez, Gomez C. [II. Probable etiology of alopecia in the Spanish lathyric patients. Results of study of toxins in fungi that develop in the external surface of the seeds of Lathyrus sativus]. Arch.Neurobiol.(Madr.) 1978;41(6):461-486. View abstract.

Ludolph, A. C. and Spencer, P. S. Toxic models of upper motor neuron disease. J Neurol.Sci 1996;139 Suppl:53-59. View abstract.

Ludolph, A. C., Hugon, J., Dwivedi, M. P., Schaumburg, H. H., and Spencer, P. S. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 1987;110 ( Pt 1):149-165. View abstract.

Melka, A., Tekle-Haimanot, R., and Lambien, F. Symptomatic treatment of neurolathyrism with tolperisone HCL (Mydocalm): a randomized double blind and placebo controlled drug trial. Ethiop.Med J 1997;35(2):77-91. View abstract.

Michaelsen, T. E. and Kolberg, J. Antigenic similarities both inside and outside the carbohydrate-binding sites of two-chain and one-chain leguminous lectins. Acta Pathol Microbiol.Immunol Scand [C.] 1984;92(1):25-35. View abstract.

Misra, U. K., Sharma, V. P., and Singh, V. P. Clinical aspects of neurolathyrism in Unnao, India. Paraplegia 1993;31(4):249-254. View abstract.

Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. View abstract.

Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. View abstract.

Ravindranath, V. Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanine. Neurochem.Int 2002;40(6):505-509. View abstract.

Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629. View abstract.

Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. View abstract.

Spencer, P. S., Hugon, J., Ludolph, A., Nunn, P. B., Ross, S. M., Roy, D. N., and Schaumburg, H. H. Discovery and partial characterization of primate motor-system toxins. Ciba Found.Symp 1987;126:221-238. View abstract.

Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. View abstract.

Striefler, M., Cohn, D. F., Hirano, A., and Schujman, E. The central nervous system in a case of neurolathyrism. Neurology 1977;27(12):1176-1178. View abstract.

Ticha, M., Zeineddine, I., and Kocourek, J. Studies on lectins. XLVIII. Isolation and characterization of lectins from the seeds of Lathyrus odoratus L. and Lathyrus silvestris L. Acta Biol.Med.Ger 1980;39(6):649-655. View abstract.

Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539. View abstract.

Warren, B. A., Patel, S. A., Nunn, P. B., and Bridges, R. J. The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-. Toxicol Appl Pharmacol 10-15-2004;200(2):83-92. View abstract.

Weintroub, S., Cohen, D. F., Salama, R., Streifler, M., and Weissman, S. L. Skeletal findings in human neutrolethyrism. Is there a human osteolathyrism? Eur Neurol. 1980;19(2):121-127. View abstract.

Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. View abstract.

CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors