- What other names is Lipase known by?
- What is Lipase?
- How does Lipase work?
- Are there safety concerns?
- Dosing considerations for Lipase.
Lipasa, Triacylglycerol Lipase.
Lipase is a digestive enzyme that is found in many plants, animals, bacteria, and molds. An enzyme is a protein that speeds up a particular biochemical reaction in the body. People use lipase as a medicine.
- Digestion problems due to a disorder of the pancreas (pancreatic insufficiency) that is associated with cystic fibrosis.
Insufficient Evidence to Rate Effectiveness for...
- Allergy to gluten in wheat products (celiac disease).
- Crohn's disease.
- Other conditions.
Lipase seems to work by breaking down fat into smaller pieces, making digestion easier.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of lipase during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Cystic fibrosis: High doses of lipase seem to make some of the symptoms of cystic fibrosis worse.
The following doses have been studied in scientific research:
- For digestion problems due to a disorder of the pancreas (pancreatic insufficiency) that is associated with cystic fibrosis: A typical dose for adults is 4500 units per kilogram of lipase per day. For children, a typical dose is 5100 units per kilogram per day. Start with a low dose and gradually increase until there is a benefit, but don't take more than the typical dose without checking with your healthcare provider.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Croft NM, Marshall TG, Ferguson A. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet 1995;346:1265-7. View abstract.
Lloyd-Still JD. Cystic fibrosis and colonic strictures. A new "iatrogenic" disease. J Clin Gastroenterol 1995;21:2-5. View abstract.
Owen G, Peters TJ, Dawson S, Goodchild MC. Pancreatic enzyme supplement dosage in cystic fibrosis. Lancet 1991;338:1153.
Smyth RL, Ashby D, O'Hea U, et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet 1995;346:1247-51. View abstract.
Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. View abstract.
Stern RC, Eisenberg JD, Wagener JS, et al. A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. Am J Gastroenterol 2000;95:1932-8. View abstract.
Thomson M, Clague A, Cleghorn GJ, Shepherd RW. Comparative in vitro and in vivo studies of enteric-coated pancrelipase preparations for pancreatic insufficiency. J Pediatr Gastroenterol Nutr 1993;17:407-13. View abstract.
Tursi JM, Phair PG, Barnes GL. Plant sources of acid stable lipases: potential therapy for cystic fibrosis. J Paediatr Child Health 1994;30:539-43. View abstract.