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Mace

What other names is Mace known by?

Fleur de Muscade, Jaatipatree, Jaiphal, Jatikosha, Jatipatra, Jatipatri, Jatiphal, Jatiphala, Jatiphalam, Javitri, Jayapatri, Mace, Macis, Muscade, Muscade et Macis, Muscadier, Muskatbuam, Myristica, Myristicae Aril, Myristica fragrans, Myristica officinalis, Noix de Muscade, Noix de Muscade et Macis, Nuez Moscada, Nuez Moscada y Macis.

What is Mace?

Nutmeg and mace are plant products. Nutmeg is the shelled, dried seed of the plant Myristica fragrans, and mace is the dried net-like covering of the shell of the seed.

Mace is taken by mouth for diarrhea, nausea, vomiting, stomach spasms and pain, and intestinal gas. It is also taken by mouth for treating cancer, kidney disease, increasing menstrual flow; causing a miscarriage, and as a hallucinogen.

Mace is applied to the skin to kill pain, especially pain caused by achy joints (rheumatism).

In foods, mace is used as a spice and flavoring.

Insufficient Evidence to Rate Effectiveness for...

  • Gum disease (gingivitis). Early research suggests that chewing gum containing mace extract after every meal for 3 weeks reduces gum inflammation, bleeding, and plaque in people with gum disease.
  • Cancer.
  • Diarrhea.
  • Increasing menstrual flow.
  • Intestinal gas.
  • Kidney disease.
  • Pain.
  • Producing hallucinations.
  • Stomach problems.
  • Vomiting.
  • Other conditions.
More evidence is needed to rate the effectiveness of mace for these uses.

How does Mace work?

Mace contains chemicals that might affect the central nervous system. Mace might also kill bacteria and fungi.

Are there safety concerns?

Mace is POSSIBLY SAFE when taken by mouth and used appropriately. Mace is a commonly used spice in foods.

Mace is POSSIBLY UNSAFE when taken in doses larger than amounts found in foods. Mace contains the chemical myristicin which has been linked to hallucinations and other mental side effects. People who have taken larger doses of nutmeg have experienced nausea, dry mouth, dizziness, irregular heartbeat, agitation and hallucinations. Because mace also contains myristicin, in theory, it might cause these same side effects.

There is not enough reliable information available to know if mace is safe to apply on the skin or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Mace is POSSIBLY UNSAFE when taken by mouth in doses larger than amounts found in foods. In pregnant women, it might cause miscarriages or birth defects.

There is not enough reliable information about the safety of taking mace if you are breast feeding. Stay on the safe side and avoid use.

Weakened immune system: Mace might reduce immune function. In theory, taking large doses of mace can worsen immune function for people who already have a weakened immune system.

Are there any interactions with medications?


Sedative medications (CNS depressants)Interaction Rating: Major Do not take this combination.

Mace might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. In theory, taking mace along with sedative medications might cause too much sleepiness.
Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.


Medications changed by the liver (Cytochrome P450 1A1 [CYP1A1] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Mace might increase how quickly the liver breaks down some medications. Taking mace along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking mace talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include chlorzoxazone, theophylline, bufuralol, and others.


Medications changed by the liver (Cytochrome P450 1A2 [CYP1A2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Mace might increase how quickly the liver breaks down some medications. Taking mace along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking mace talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.


Medications changed by the liver (Cytochrome P450 2B1 [CYP2B1] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Mace might increase how quickly the liver breaks down some medications. Taking mace along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking mace talk to your healthcare provider if you take any medications that are changed by the liver.


Medications changed by the liver (Cytochrome P450 2B2 [CYP2B2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Taking mace along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking mace talk to your healthcare provider if you take any medications that are changed by the liver.


Medications that decrease the immune system (Immunosuppressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Mace might decrease the activity of the immune system. Taking mace along with some medications that also decrease the immune system might increase these medications' effects.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids), and others.


Phenobarbital (Luminal)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

The body breaks down phenobarbital (Luminal) to get rid of it. Mace might increase how quickly the body breaks down phenobarbital (Luminal). Taking mace along with phenobarbital (Luminal) might decrease the effectiveness of phenobarbital (Luminal).

Dosing considerations for Mace.

BY MOUTH:

  • For gum disease (gingivitis): Chewing gum containing mace extract has been used after every meal for 3 weeks.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019
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