- What other names is Maitake Mushroom known by?
- What is Maitake Mushroom?
- How does Maitake Mushroom work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Maitake Mushroom.
Champignon Dansant, Champignon des Fous Dansants, Champignon Maitake, Dancing Mushroom, Grifola, Grifola frondosa, Hen of the Woods, Hongo Maitake, King of Mushrooms, Maitake, Monkey's Bench, Mushroom, Roi des Champignons, Shelf Fungi.
Maitake mushroom is a fungus that has been eaten as food in Asia for thousands of years. People also use it to make medicine.
Maitake mushroom is used to treat cancer and also to relieve some of the side effects of chemical treatment (chemotherapy) for cancer. It is also used for HIV/AIDS, chronic fatigue syndrome (CFS), hepatitis, hay fever, diabetes, high blood pressure, high cholesterol, weight loss or control, and infertility due to a condition called polycystic ovary syndrome.
If you decide to harvest maitake mushrooms, make sure you can tell them apart from poisonous mushrooms. This job is probably best left to experts.
Insufficient Evidence to Rate Effectiveness for...
- Diabetes. Early research suggests that taking maitake mushroom polysaccharides (MMP) by mouth may lower blood sugar in people with diabetes.
- An ovary disorder known as polycystic ovary syndrome (PCOS). Early research shows that taking a specific product (SX-Fraction by Mushroom Wisdom) containing maitake mushroom extract can improve ovulation in women whose periods have stopped due to PCOS. Maitake mushroom does not appear to be as effective as clomiphene for PCOS, but the combination of these two agents seems to be more effective than either agent alone for improving ovulation.
- Chronic fatigue syndrome (CFS).
- Hay fever.
- High blood pressure.
- High cholesterol.
- Weight loss or control.
- Chemotherapy support.
- Other conditions.
Maitake mushroom contains chemicals which might help fight tumors and stimulate the immune system. There is some evidence that it can lower blood pressure, improve cholesterol levels, lower blood sugar levels, and reduce weight in rats, but this has not been shown for humans yet.
Maitake mushroom is POSSIBLY SAFE for most people when taken by mouth as medicine, but there isn't much information about the potential side effects.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking maitake mushroom if you are pregnant or breast-feeding . Stay on the safe side and avoid use..
Diabetes: Maitake mushroom might lower blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.
Surgery: Maitake mushroom might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using maitake mushroom at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Maitake mushroom might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking maitake mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Maitake mushroom might decrease blood pressure in some people. Taking maitake mushroom along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.
Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Maitake mushroom might increase the blood thinning effects of warfarin (Coumadin) and potentially increase the chance of bleeding. Your healthcare provider may need to monitor your blood more often if you take maitake mushroom along with warfarin (Coumadin). The dose of your warfarin (Coumadin) medication may need to be changed.
The appropriate dose of maitake mushroom depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for maitake mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Health Solutions From Our Sponsors
Adachi, K., Nanba, H., Otsuka, M., and Kuroda, H. Blood pressure-lowering activity present in the fruit body of Grifola frondosa (maitake). I. Chem.Pharm.Bull.(Tokyo) 1988;36(3):1000-1006. View abstract.
Adachi, Y., Ohno, N., and Yadomae, T. Activation of murine kupffer cells by administration with gel-forming (1-->3)-beta-D-glucan from Grifola frondosa. Biol Pharm Bull 1998;21(3):278-283. View abstract.
Adachi, Y., Okazaki, M., Ohno, N., and Yadomae, T. Enhancement of cytokine production by macrophages stimulated with (1-- >3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa. Biol Pharm Bull 1994;17(12):1554-1560. View abstract.
Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., and Yun, J. W. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol.Lett 10-15-2005;251(2):347-354. View abstract.
Chang, R. Functional properties of edible mushrooms. Nutr Rev 1996;54(11 Pt 2):S91-S93. View abstract.
Cui, F. J., Li, Y., Xu, Y. Y., Liu, Z. Q., Huang, D. M., Zhang, Z. C., and Tao, W. Y. Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol In Vitro 2007;21(3):417-427. View abstract.
Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. View abstract.
Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., and Nakano, M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood.) 2001;226(8):758-765. View abstract.
Fullerton, S. A., Samadi, A. A., Tortorelis, D. G., Choudhury, M. S., Mallouh, C., Tazaki, H., and Konno, S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol Urol 2000;4(1):7-13. View abstract.
Gonmori, K. and Yokoyama, K. [Acute encephalopathy caused by cyanogenic fungi in 2004, and magic mushroom regulation in Japan]. Chudoku.Kenkyu 2009;22(1):61-69. View abstract.
Gu, C. Q., Li, J. W., Chao, F., Jin, M., Wang, X. W., and Shen, Z. Q. Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa. Antiviral Res 2007;75(3):250-257. View abstract.
Gu, C. Q., Li, J., and Chao, F. H. Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15. Antiviral Res 2006;72(2):162-165. View abstract.
Hong, L., Xun, M., and Wutong, W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharm Pharmacol 2007;59(4):575-582. View abstract.
Horio, H. and Ohtsuru, M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol.(Tokyo) 2001;47(1):57-63. View abstract.
Inoue, A., Kodama, N., and Nanba, H. Effect of maitake (grifolafrondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 2002;25(4):536-540. View abstract.
Ishibashi, K., Miura, N. N., Adachi, Y., Ohno, N., and Yadomae, T. Relationship between solubility of grifolan, a fungal 1,3-beta-D- glucan, and production of tumor necrosis factor by macrophages in vitro. Biosci Biotechnol Biochem 2001;65(9):1993-2000. View abstract.
Kidd, P. M. The use of mushroom glucans and proteoglycans in cancer treatment. Altern.Med Rev. 2000;5(1):4-27. View abstract.
Kodama, N., Komuta, K., and Nanba, H. Can maitake MD-fraction aid cancer patients? Altern.Med Rev 2002;7(3):236-239. View abstract.
Kurashige, S., Akuzawa, Y., and Endo, F. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N- butanolnitrosoamine. Immunopharmacol.Immunotoxicol. 1997;19(2):175-183. View abstract.
Li, X., Rong, J., Wu, M., and Zeng, X. [Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function]. Zhong.Yao Cai. 2003;26(1):31-32. View abstract.
Lin, J. T. and Liu, W. H. o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis. J Agric Food Chem 10-4-2006;54(20):7564-7569. View abstract.
Manohar, V., Talpur, N. A., Echard, B. W., Lieberman, S., and Preuss, H. G. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes.Metab 2002;4(1):43-48. View abstract.
Matsui, K., Kodama, N., and Nanba, H. Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis. Cancer Lett 10-30-2001;172(2):193-198. View abstract.
Mayell, M. Maitake extracts and their therapeutic potential. Altern Med Rev 2001;6(1):48-60. View abstract.
Miura, N. N., Ohno, N., Aketagawa, J., Tamura, H., Tanaka, S., and Yadomae, T. Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice. FEMS Immunol Med Microbiol 1996;13(1):51-57. View abstract.
Nanba, H. Maitake D-fraction: Healing and preventing potentials for cancer. Townsend Letter for Doctors & Patients 1996;151/152:84-85.
Ohno, N., Egawa, Y., Hashimoto, T., Adachi, Y., and Yadomae, T. Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice. Biol Pharm Bull 1996;19(4):608-612. View abstract.
Okazaki, M., Adachi, Y., Ohno, N., and Yadomae, T. Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro. Biol Pharm Bull 1995;18(10):1320-1327. View abstract.
Preuss, H. G., Echard, B., Bagchi, D., Perricone, N. V., and Zhuang, C. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol.Cell Biochem 2007;306(1-2):105-113. View abstract.
Sanzen, I., Imanishi, N., Takamatsu, N., Konosu, S., Mantani, N., Terasawa, K., Tazawa, K., Odaira, Y., Watanabe, M., Takeyama, M., and Ochiai, H. Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7. J Exp Clin Cancer Res 2001;20(4):591-597. View abstract.
Sliva, D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini.Rev.Med Chem. 2004;4(8):873-879. View abstract.
Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11(2):128-150. View abstract.
Suzuki, I., Hashimoto, K., Oikawa, S., Sato, K., Osawa, M., and Yadomae, T. Antitumor and immunomodulating activities of a beta-glucan obtained from liquid-cultured Grifola frondosa. Chem Pharm Bull (Tokyo) 1989;37(2):410-413. View abstract.
Suzuki, I., Itani, T., Ohno, N., Oikawa, S., Sato, K., Miyazaki, T., and Yadomae, T. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa. J Pharmacobiodyn. 1984;7(7):492-500. View abstract.
Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. View abstract.
Tanaka, H., Tsunematsu, K., Nakamura, N., Suzuki, K., Tanaka, N., Takeya, I., Saikai, T., and Abe, S. Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol. Intern.Med. 2004;43(8):737-740. View abstract.
Wu, M. J., Cheng, T. L., Cheng, S. Y., Lian, T. W., Wang, L., and Chiou, S. Y. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric.Food Chem 4-19-2006;54(8):2906-2914. View abstract.
Yang, B. K., Gu, Y. A., Jeong, Y. T., Jeong, H., and Song, C. H. Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process. Int J Biol Macromol. 8-1-2007;41(3):227-233. View abstract.
Yang, D., Li, S., Wang, H., Li, X., Liu, S., Han, W., Hao, J., and Zhang, H. [Prevention of postoperative recurrence of bladder cancer: a clinical study]. Zhonghua Wai Ke.Za Zhi. 1999;37(8):464-465. View abstract.
Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo) 1987;35:262-70. View abstract.
Borchers AT, Stern JS, Hackman RM, et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 1999;221:281-293. View abstract.
Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 2010;16:1295-9. View abstract.
Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. View abstract.
Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. View abstract.
Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. View abstract.
Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. View abstract.
Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 1994;17:1106-10. View abstract.
Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Alt Ther Health Med 1996;2:62-6. View abstract.
Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann N Y Acad Sci 1997;833:204-7. View abstract.
Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann N Y Acad Sci 1995;768:243-5. View abstract.