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Symptoms and Signs of Nephrotic Syndrome

Doctor's Notes on Nephrotic Syndrome

Nephrotic syndrome is a kidney disorder that results in protein lost in the urine (proteinuria) due to leaks in the filtering system of the kidney. Symptoms and signs of nephrotic syndrome may include

The causes of nephrotic syndrome are numerous and variable. Almost any problem (such as trauma to the kidneys, certain drugs, diseases, or genetic makeup) that causes or allows damage to the glomeruli of the kidney can cause nephrotic syndrome. Primary causes (kidney diseases like focal glomerulosclerosis) and secondary causes are underlying problems. Examples include diabetes, lupus, heroin use, and genetic mutations (for example, congenital focal glomerulosclerosis). Treatments vary. Treating the underlying cause is the usual approach, like the use of immune-suppressing drugs for autoimmune diseases, but symptom reduction treatments may also be done such as swelling reduction by using diuretics. Each person is different. Your doctor should perform individual treatments.

Medical Author:
Medically Reviewed on 12/2/2019


Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.