Nikko Maple

Other Name(s):

Acer nikoense, Arce Nikoense, Érable de Nikko, Megusurinoki.


Nikko maple is a tree. The bark is used to make medicine.

People take nikko maple for eye diseases and liver disorders.

How does it work?

Preliminary research suggests nikko maple might decrease swelling (inflammation). It might also kill cancer cells in test tubes.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of nikko maple for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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Side Effects

It is not known if nikko maple is safe or what the possible side effects might be.

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of nikko maple during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of nikko maple depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for nikko maple. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Reviewed on 6/14/2021

Morikawa T, Tao J, Toguchida I, et al. Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense. J Nat Prod 2003;66:86-91. View abstract.

Morikawa T, Tao J, Ueda K, et al. Medicinal foodstuffs. XXXI. Structures of new aromatic constituents and inhibitors of degranulation in RBL-2H3 cells from a Japanese folk medicine, the stem bark of Acer nikoense. Chem Pharm Bull (Tokyo) 2003;51:62-7. View abstract.

Nitta K, Ogawa Y, Negishi F, et al. Hot water extract of bark of Nikko maple (Acer nikoense) induces apoptosis in leukemia cells. Biol Pharm Bull 1999;22:378-81. View abstract.

Sakagami H, Anzai S, Goto S, Takeda M. Enhancement of cytotoxic activity of ascorbate by Acer nikoense Maxim. Extracts. Anticancer Res 1997;17:4453-6. View abstract.

Satoh K, Anzai S, Sakagami H. Radical scavenging activity of Acer nikoense Maxim. extract. Anticancer Res 1998;18:833-7. View abstract.

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